Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | oxidoreductase | 0.0025 | 0 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0122 | 0.3357 | 0.3357 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0025 | 0 | 0.5 |
Echinococcus multilocularis | muscleblind protein | 0.0316 | 1 | 1 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0025 | 0 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0025 | 0 | 0.5 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0025 | 0 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0025 | 0 | 0.5 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0122 | 0.3357 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.3357 | 0.3357 |
Echinococcus granulosus | muscleblind protein | 0.0316 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 1 | 1 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0025 | 0 | 0.5 |
Onchocerca volvulus | 0.0133 | 0.3713 | 0.5 | |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0025 | 0 | 0.5 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0356 | 0.0356 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0316 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0025 | 0 | 0.5 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0025 | 0 | 0.5 |
Mycobacterium ulcerans | dehydrogenase | 0.0025 | 0 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0025 | 0 | 0.5 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0025 | 0 | 0.5 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0025 | 0 | 0.5 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0035 | 0.0356 | 0.0356 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.3357 | 0.3357 |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.3713 | 0.3713 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0025 | 0 | 0.5 |
Mycobacterium ulcerans | monoamine oxidase | 0.0025 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0025 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0025 | 0 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0025 | 0 | 0.5 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0122 | 0.3357 | 0.3357 |
Brugia malayi | SWIRM domain containing protein | 0.0133 | 0.3713 | 0.3713 |
Leishmania major | UDP-galactopyranose mutase | 0.0025 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.