Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0523 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0192 | 1 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0192 | 1 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0523 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0192 | 1 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0192 | 1 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0192 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0523 | 0.5 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0192 | 1 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0523 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0523 | 0.5 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0192 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0192 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0523 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.