Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Probable lipase LipE | 0.0037 | 0.0036 | 0.5 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0537 | 0.6292 | 0.6279 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0037 | 0.0036 | 0.5 |
Echinococcus multilocularis | TRP (transient receptor potential) channel | 0.031 | 0.3449 | 0.3425 |
Onchocerca volvulus | Huntingtin homolog | 0.0123 | 0.1116 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.031 | 0.3449 | 0.3449 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0199 | 0.0199 |
Toxoplasma gondii | ABC1 family protein | 0.0037 | 0.0036 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0036 | 0.0036 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0036 | 0.0036 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.1116 | 0.1116 |
Brugia malayi | hypothetical protein | 0.0123 | 0.1116 | 0.3236 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0833 | 1 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0037 | 0.0036 | 0.5 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0551 | 0.6469 | 0.6456 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0036 | 0.0036 |
Echinococcus granulosus | TRP transient receptor potential channel | 0.031 | 0.3449 | 0.3425 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0199 | 0.0577 |
Loa Loa (eye worm) | beta-lactamase | 0.0037 | 0.0036 | 0.0036 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0537 | 0.6292 | 0.6279 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0037 | 0.0036 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0036 | 0.0036 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0036 | 0.5 |
Brugia malayi | Transient-receptor-potential like protein | 0.031 | 0.3449 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0238 | 0.2547 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0037 | 0.0036 | 0.5 |
Brugia malayi | beta-lactamase | 0.0037 | 0.0036 | 0.0104 |
Onchocerca volvulus | Huntingtin homolog | 0.0123 | 0.1116 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0037 | 0.0036 | 0.0104 |
Schistosoma mansoni | transient receptor potential channel | 0.0551 | 0.6469 | 0.6469 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0036 | 0.0036 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0036 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0037 | 0.0036 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0036 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0036 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0551 | 0.6469 | 0.6469 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0551 | 0.6469 | 0.6456 |
Loa Loa (eye worm) | hypothetical protein | 0.0523 | 0.6121 | 0.6121 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0036 | 0.0104 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0805 | 0.9652 | 0.9651 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0036 | 0.0036 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0036 | 0.0104 |
Plasmodium vivax | hypothetical protein, conserved | 0.0037 | 0.0036 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0037 | 0.0036 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0037 | 0.0036 | 0.5 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0805 | 0.9652 | 0.9651 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0036 | 0.0036 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0199 | 0.0577 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0037 | 0.0036 | 0.0036 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0036 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.3101 | 0.3101 |
Loa Loa (eye worm) | hypothetical protein | 0.0833 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0036 | 0.0036 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.1116 | 0.1116 |
Mycobacterium ulcerans | beta-lactamase | 0.0037 | 0.0036 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0036 | 0.5 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0551 | 0.6469 | 0.6456 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0833 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0199 | 0.0199 |
Mycobacterium leprae | conserved hypothetical protein | 0.0037 | 0.0036 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0833 | 1 | 1 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0551 | 0.6469 | 0.6456 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0036 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.