Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0071 | 0.5779 | 0.5779 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0071 | 0.5779 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.5779 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.5779 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.5779 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0071 | 0.5779 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.5779 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0071 | 0.5779 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.5779 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 20.7865 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.