Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase IV, putative | 0.0045 | 0.0067 | 0.2858 |
Schistosoma mansoni | apoptosis regulator bax | 0.0366 | 0.1654 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0321 | 0.1435 | 0.7691 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0067 | 0.2858 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0404 | 0.1845 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0366 | 0.1654 | 1 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0203 | 0.0847 | 0.5106 |
Trypanosoma brucei | unspecified product | 0.0038 | 0.0031 | 0.0969 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0033 | 0.0006 | 0.0006 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0091 | 0.0296 | 0.176 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.07 | 0.3311 | 1 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE | 0.0404 | 0.1845 | 1 |
Echinococcus multilocularis | aryl hydrocarbon receptor | 0.0151 | 0.0591 | 0.0586 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0498 | 0.2987 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.07 | 0.3311 | 0.5 |
Loa Loa (eye worm) | glutaminase 2 | 0.0301 | 0.1332 | 0.8044 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0321 | 0.1435 | 0.7691 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0063 | 0.0156 | 0.0156 |
Chlamydia trachomatis | transglycolase/transpeptidase | 0.07 | 0.3311 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0067 | 0.2858 |
Onchocerca volvulus | 0.0261 | 0.1133 | 1 | |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0073 | 0.0203 | 0.1194 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0296 | 0.176 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0144 | 0.0556 | 0.1513 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0063 | 0.0156 | 0.015 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0321 | 0.1435 | 0.7691 |
Brugia malayi | aryl hydrocarbon receptor AHR-1 | 0.0132 | 0.0498 | 0.2987 |
Loa Loa (eye worm) | glutaminase | 0.0301 | 0.1332 | 0.8044 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0067 | 0.2858 |
Trichomonas vaginalis | set domain proteins, putative | 0.0261 | 0.1133 | 0.5995 |
Mycobacterium ulcerans | penicillin-binding membrane protein PbpB | 0.0698 | 0.3298 | 1 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0059 | 0.0135 | 0.0781 |
Mycobacterium ulcerans | glutaminase | 0.0301 | 0.1332 | 0.3914 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0063 | 0.0156 | 0.0909 |
Loa Loa (eye worm) | hypothetical protein | 0.0366 | 0.1654 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0073 | 0.0203 | 0.0203 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0067 | 0.2858 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0052 | 0.01 | 0.0094 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0321 | 0.1435 | 1 |
Treponema pallidum | penicillin-binding protein (pbp-2) | 0.0404 | 0.1845 | 0.2188 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0073 | 0.0203 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0229 | 0.0976 | 0.5889 |
Brugia malayi | Apoptosis regulator proteins, Bcl-2 family protein | 0.0366 | 0.1654 | 1 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0091 | 0.0296 | 0.176 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0063 | 0.0156 | 0.0909 |
Schistosoma mansoni | glutaminase | 0.0301 | 0.1332 | 0.8044 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0229 | 0.0976 | 0.5889 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0091 | 0.0296 | 0.0296 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0033 | 0.0006 | 0.5 |
Echinococcus granulosus | aryl hydrocarbon receptor | 0.0151 | 0.0591 | 0.0591 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0073 | 0.0203 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0321 | 0.1435 | 0.7691 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0067 | 0.2858 |
Onchocerca volvulus | 0.0052 | 0.0103 | 0.0858 | |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0157 | 0.0621 | 0.1714 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0067 | 0.2858 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0157 | 0.0621 | 0.0502 |
Echinococcus multilocularis | Bcl 2 ous antagonist:killer | 0.0366 | 0.1654 | 0.1649 |
Mycobacterium ulcerans | bifunctional penicillin-binding protein 1A/1B PonA1 | 0.0404 | 0.1845 | 0.5502 |
Echinococcus multilocularis | dna polymerase kappa | 0.0045 | 0.0067 | 0.0061 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0321 | 0.1435 | 0.7691 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.013 | 0.0486 | 0.048 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0501 | 0.3005 |
Mycobacterium ulcerans | putative regulatory protein | 0.0052 | 0.01 | 0.0101 |
Mycobacterium tuberculosis | Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen | 0.027 | 0.1182 | 0.6211 |
Onchocerca volvulus | 0.015 | 0.0588 | 0.5166 | |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.013 | 0.0486 | 0.0486 |
Mycobacterium tuberculosis | Probable penicillin-binding protein PbpA | 0.0397 | 0.1808 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0038 | 0.0031 | 0.0969 |
Treponema pallidum | penicillin-binding protein (pbp-3) | 0.0698 | 0.3298 | 0.9933 |
Schistosoma mansoni | single-minded | 0.007 | 0.019 | 0.1115 |
Schistosoma mansoni | lipoxygenase | 0.0091 | 0.0292 | 0.1738 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0157 | 0.0621 | 0.2814 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0063 | 0.0156 | 0.0275 |
Brugia malayi | glutaminase DH11.1 | 0.0301 | 0.1332 | 0.8044 |
Schistosoma mansoni | bcl-2 homologous antagonist/killer (bak) | 0.0366 | 0.1654 | 1 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0073 | 0.0203 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0366 | 0.1654 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0321 | 0.1435 | 1 |
Mycobacterium ulcerans | bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 | 0.027 | 0.1182 | 0.3451 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0144 | 0.0556 | 0.2422 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0045 | 0.0067 | 0.2858 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.2052 | 1 | 1 |
Trichomonas vaginalis | glutaminase, putative | 0.0301 | 0.1332 | 0.7113 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0067 | 0.2858 |
Mycobacterium tuberculosis | Probable penicillin-binding membrane protein PbpB | 0.025 | 0.1083 | 0.5612 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0091 | 0.0296 | 0.029 |
Echinococcus granulosus | Bcl 2 ous antagonist:killer | 0.0366 | 0.1654 | 0.1654 |
Mycobacterium leprae | Probable penicillin-binding protein PbpA | 0.0397 | 0.1808 | 0.9714 |
Loa Loa (eye worm) | apoptosis regulator protein | 0.0366 | 0.1654 | 1 |
Mycobacterium leprae | Probable penicillin-binding membrane protein PbpB | 0.025 | 0.1083 | 0.409 |
Brugia malayi | polk-prov protein | 0.0034 | 0.0013 | 0.0041 |
Schistosoma mansoni | lipoxygenase | 0.013 | 0.0486 | 0.291 |
Echinococcus granulosus | dna polymerase kappa | 0.0045 | 0.0067 | 0.0067 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0073 | 0.0203 | 0.1194 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0588 | 0.3533 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0073 | 0.0203 | 0.1194 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN | 0.027 | 0.1182 | 0.4857 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0321 | 0.1435 | 0.7691 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0013 | 0.0041 |
Brugia malayi | PAS domain containing protein | 0.007 | 0.019 | 0.1115 |
Plasmodium vivax | SET domain protein, putative | 0.0033 | 0.0006 | 0.5 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0042 | 0.0051 | 0.0051 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0321 | 0.1435 | 0.7691 |
Mycobacterium tuberculosis | Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase | 0.0134 | 0.0506 | 0.2122 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0073 | 0.0203 | 0.0197 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0067 | 0.2858 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.0397 | 0.1808 | 0.5388 |
Echinococcus granulosus | single minded 2 | 0.0052 | 0.01 | 0.01 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0063 | 0.0156 | 0.0275 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0321 | 0.1435 | 0.5 |
Brugia malayi | bHLH-PAS transcription factor | 0.0052 | 0.01 | 0.0569 |
Schistosoma mansoni | hypothetical protein | 0.0366 | 0.1654 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.0067 | 0.2858 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0073 | 0.0203 | 1 |
Onchocerca volvulus | 0.0091 | 0.0296 | 0.2574 | |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0321 | 0.1435 | 0.7691 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0042 | 0.0051 | 0.0046 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 48 uM | Inhibitory activity against histamine release from antigen-challenged, sensitized human basophils | ChEMBL. | 2415706 |
IC50 (functional) | > 48 uM | Inhibitory activity against histamine release from antigen-challenged, sensitized human basophils | ChEMBL. | 2415706 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.