Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | tubulin gamma chain, putative | 0.003 | 0.1314 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.003 | 0.1314 | 0.5 |
Leishmania major | beta tubulin | 0.003 | 0.1314 | 0.5 |
Toxoplasma gondii | beta-tubulin, putative | 0.003 | 0.1314 | 0.5 |
Leishmania major | beta tubulin | 0.003 | 0.1314 | 0.5 |
Leishmania major | beta tubulin | 0.003 | 0.1314 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.003 | 0.1314 | 0.5 |
Echinococcus granulosus | beta tubulin | 0.003 | 0.1314 | 0.5 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.003 | 0.1314 | 0.5 |
Leishmania major | beta tubulin | 0.003 | 0.1314 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.003 | 0.1314 | 0.5 |
Leishmania major | beta tubulin | 0.003 | 0.1314 | 0.5 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0013 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.003 | 0.1314 | 0.5 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.014 | 0.9739 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.9025 | 0.8877 |
Brugia malayi | beta-tubulin, identical | 0.003 | 0.1314 | 0.5 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0091 | 0.6046 | 1 |
Toxoplasma gondii | beta tubulin | 0.003 | 0.1314 | 0.5 |
Leishmania major | beta tubulin | 0.003 | 0.1314 | 0.5 |
Leishmania major | beta tubulin | 0.003 | 0.1314 | 0.5 |
Echinococcus granulosus | tubulin beta 1 chain | 0.003 | 0.1314 | 0.5 |
Leishmania major | beta tubulin | 0.003 | 0.1314 | 0.5 |
Leishmania major | beta tubulin | 0.003 | 0.1314 | 0.5 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.003 | 0.1314 | 0.5 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.003 | 0.1314 | 0.5 |
Plasmodium falciparum | tubulin beta chain | 0.003 | 0.1314 | 0.5 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.003 | 0.1314 | 0.5 |
Brugia malayi | Tubulin beta-1 chain | 0.003 | 0.1314 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.003 | 0.1314 | 0.5 |
Echinococcus granulosus | tubulin subunit beta | 0.003 | 0.1314 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.003 | 0.1314 | 0.5 |
Trichomonas vaginalis | tubulin, putative | 0.003 | 0.1314 | 0.5 |
Plasmodium vivax | tubulin beta chain, putative | 0.003 | 0.1314 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.6307 | 0.5748 |
Leishmania major | beta tubulin | 0.003 | 0.1314 | 0.5 |
Entamoeba histolytica | tubulin family protein | 0.003 | 0.1314 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.003 | 0.1314 | 0.5 |
Trypanosoma cruzi | beta tubulin, putative | 0.003 | 0.1314 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.003 | 0.1314 | 0.5 |
Leishmania major | beta tubulin | 0.003 | 0.1314 | 0.5 |
Leishmania major | beta tubulin | 0.003 | 0.1314 | 0.5 |
Giardia lamblia | Beta tubulin | 0.003 | 0.1314 | 0.5 |
Giardia lamblia | Beta tubulin | 0.003 | 0.1314 | 0.5 |
Entamoeba histolytica | tubulin family protein | 0.003 | 0.1314 | 0.5 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.003 | 0.1314 | 0.5 |
Leishmania major | beta tubulin | 0.003 | 0.1314 | 0.5 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.003 | 0.1314 | 0.5 |
Giardia lamblia | Beta tubulin | 0.003 | 0.1314 | 0.5 |
Echinococcus granulosus | beta tubulin | 0.003 | 0.1314 | 0.5 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.003 | 0.1314 | 0.5 |
Leishmania major | beta tubulin | 0.003 | 0.1314 | 0.5 |
Leishmania major | beta tubulin | 0.003 | 0.1314 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.003 | 0.1314 | 0.5 |
Leishmania major | beta tubulin | 0.003 | 0.1314 | 0.5 |
Leishmania major | beta tubulin | 0.003 | 0.1314 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AUC (ADMET) | = 0.112 ug hr ml-1 | The oral Area under the plasma concentration curve(AUC) measured;when administered perorally | ChEMBL. | 11931625 |
Cmax (ADMET) | = 0.07 ug ml-1 | Maximum concentration of compound present in plasma measured | ChEMBL. | 11931625 |
F (ADMET) | = 2.5 % | Bioavailability | ChEMBL. | 11931625 |
IC50 (functional) | = 27 nM | Inhibition of human HCT-15 (human colon adenocarcinoma, MDR positive) cell growth | ChEMBL. | 11931625 |
IC50 (functional) | = 27 nM | Inhibition of human HCT-15 (human colon adenocarcinoma, MDR positive) cell growth | ChEMBL. | 11931625 |
IC50 (functional) | = 51 nM | Inhibition of human NCI-H460 (human lung large cell carcinoma, MDR negative) cell growth | ChEMBL. | 11931625 |
IC50 (functional) | = 51 nM | Inhibition of human NCI-H460 (human lung large cell carcinoma, MDR negative) cell growth | ChEMBL. | 11931625 |
ND (functional) | 0 | Concentration needed to inhibit the tubulin polymerization by 50%, ND is Not Determined | ChEMBL. | 11931625 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 11931625 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.