Detailed information for compound 705958

Basic information

Technical information
  • TDR Targets ID: 705958
  • Name: N'-(4-chlorophenyl)-N-[2-[2-(2-methylphenyl)- [1,3]thiazolo[2,3-e][1,2,4]triazol-6-yl]ethyl ]oxamide
  • MW: 439.918 | Formula: C21H18ClN5O2S
  • H donors: 2 H acceptors: 4 LogP: 4.38 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)NC(=O)C(=O)NCCc1csc2n1nc(n2)c1ccccc1C
  • InChi: 1S/C21H18ClN5O2S/c1-13-4-2-3-5-17(13)18-25-21-27(26-18)16(12-30-21)10-11-23-19(28)20(29)24-15-8-6-14(22)7-9-15/h2-9,12H,10-11H2,1H3,(H,23,28)(H,24,29)
  • InChiKey: FLQOMWZOYJKLKJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N'-(4-chlorophenyl)-N-[2-[2-(2-methylphenyl)thiazolo[2,3-e][1,2,4]triazol-6-yl]ethyl]oxamide
  • N'-(4-chlorophenyl)-N-[2-[2-(2-methylphenyl)-6-thiazolo[2,3-e][1,2,4]triazolyl]ethyl]oxamide
  • N'-(4-chlorophenyl)-N-[2-[2-(2-methylphenyl)-[1,3]thiazolo[2,3-e][1,2,4]triazol-6-yl]ethyl]ethanediamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0027 0.1004 0.4263
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.2354 1
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.1532 0.5
Brugia malayi Augmenter of liver regeneration 0.0034 0.1532 0.6345
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.2354 1
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0034 0.1532 0.6505
Onchocerca volvulus 0.0027 0.1004 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.2354 1
Echinococcus multilocularis lamin 0.0027 0.1004 0.4263
Echinococcus multilocularis ornithine aminotransferase 0.0022 0.0618 0.2627
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0034 0.1532 0.6505
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0152 1 1
Loa Loa (eye worm) hepatopoietin HPO2 0.0034 0.1532 0.6505
Onchocerca volvulus 0.0027 0.1004 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0968 0.4113
Echinococcus granulosus intermediate filament protein 0.0027 0.1004 0.4263
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0022 0.0618 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.2354 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.1004 0.4263
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.1004 0.4001
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.1532 1
Schistosoma mansoni intermediate filament proteins 0.0027 0.1004 0.222
Echinococcus granulosus lamin dm0 0.0027 0.1004 0.4263
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0022 0.0618 0.5
Leishmania major hypothetical protein, conserved 0.0034 0.1532 0.5
Mycobacterium tuberculosis Probable aminotransferase 0.0152 1 1
Echinococcus multilocularis musashi 0.0027 0.1004 0.4263
Schistosoma mansoni lamin 0.0027 0.1004 0.222
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.1532 0.5
Echinococcus multilocularis Aminotransferase class III 0.0022 0.0618 0.2627
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0022 0.0618 0.2289
Echinococcus multilocularis lamin dm0 0.0027 0.1004 0.4263
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.1532 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.2354 1
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0152 1 0.5
Mycobacterium ulcerans hypothetical protein 0.0152 1 1
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.1532 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0103 0.0438
Echinococcus multilocularis ornithine aminotransferase 0.0022 0.0618 0.2627
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.2354 1
Echinococcus granulosus ornithine aminotransferase 0.0022 0.0618 0.2627
Loa Loa (eye worm) intermediate filament protein 0.0027 0.1004 0.4263
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.2354 1
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.1532 0.5
Schistosoma mansoni lamin 0.0027 0.1004 0.222
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.1532 1
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.1532 1
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0152 1 1
Echinococcus granulosus Aminotransferase class III 0.0022 0.0618 0.2627
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.2354 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.2354 1
Brugia malayi intermediate filament protein 0.0027 0.1004 0.4001
Echinococcus granulosus lamin 0.0027 0.1004 0.4263

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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