Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0463 | 0.0207 |
Schistosoma mansoni | glutaminase | 0.0267 | 0.9035 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0463 | 0.0558 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0139 | 0.4643 | 0.4499 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0463 | 0.0338 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.0463 | 0.0207 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0463 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.0463 | 0.3151 |
Echinococcus granulosus | geminin | 0.0165 | 0.5536 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0295 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.5536 | 0.6056 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.3899 | 0.421 |
Loa Loa (eye worm) | RecQ helicase | 0.0023 | 0.0638 | 0.0535 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0041 | 0.126 | 0.1025 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0295 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0041 | 0.126 | 0.1025 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0021 | 0.054 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.0463 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0463 | 0.0338 |
Loa Loa (eye worm) | glutaminase 2 | 0.0267 | 0.9035 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0463 | 0.7958 |
Echinococcus granulosus | bloom syndrome protein | 0.0023 | 0.0638 | 0.0884 |
Mycobacterium ulcerans | glutaminase | 0.0267 | 0.9035 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0155 | 0.5187 | 0.5511 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0463 | 0.0558 |
Brugia malayi | glutaminase DH11.1 | 0.0267 | 0.9035 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0051 | 0.1573 | 0.1346 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0463 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0139 | 0.4643 | 0.4499 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0041 | 0.126 | 0.1025 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0463 | 0.023 |
Toxoplasma gondii | hypothetical protein | 0.0048 | 0.147 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0016 | 0.037 | 0.2517 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0463 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0155 | 0.5187 | 1 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0139 | 0.4643 | 0.4499 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0463 | 0.0338 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0164 | 0.1113 |
Echinococcus multilocularis | geminin | 0.0165 | 0.5536 | 1 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0023 | 0.0638 | 0.0535 |
Loa Loa (eye worm) | glutaminase | 0.0267 | 0.9035 | 1 |
Entamoeba histolytica | recQ family helicase, putative | 0.0013 | 0.0262 | 0.5651 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0295 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0041 | 0.126 | 0.1025 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.0463 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0164 | 0.1113 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0023 | 0.0638 | 0.0429 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0018 | 0.0468 | 0.0343 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0463 | 0.023 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0463 | 0.0338 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.0463 | 0.0207 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.5536 | 0.6056 |
Echinococcus multilocularis | bloom syndrome protein | 0.0023 | 0.0638 | 0.0884 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0463 | 0.0207 |
Trichomonas vaginalis | glutaminase, putative | 0.0267 | 0.9035 | 1 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0023 | 0.0638 | 0.0429 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.