Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0039 | 0.0925 | 0.0925 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.312 | 0.312 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0034 | 0.023 | 0.0327 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.312 | 0.6667 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0045 | 0.1721 | 0.1721 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0052 | 0.2663 | 0.2663 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0742 | 0.1054 |
Giardia lamblia | PHD finger protein 15 | 0.0032 | 0 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0039 | 0.0925 | 0.1313 |
Onchocerca volvulus | Alhambra homolog | 0.0032 | 0 | 0.5 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0105 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2193 | 0.4685 |
Schistosoma mansoni | jumonji domain containing protein | 0.0084 | 0.7041 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0402 | 0.0859 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0742 | 0.0742 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0742 | 0.1586 |
Plasmodium falciparum | phd finger protein, putative | 0.0032 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.312 | 0.6667 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0105 | 1 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0039 | 0.0925 | 0.1313 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0066 | 0.468 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.314 | 0.6709 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0032 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0032 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2835 | 0.6058 |
Echinococcus granulosus | jumonji domain containing protein | 0.0045 | 0.1721 | 0.1721 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.312 | 0.312 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0039 | 0.0925 | 0.0925 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0039 | 0.0925 | 0.1976 |
Brugia malayi | jmjC domain containing protein | 0.0039 | 0.0925 | 0.0925 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0032 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.