Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 1 (interstitial collagenase) | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Matrixin family protein | matrix metallopeptidase 1 (interstitial collagenase) | 403 aa | 401 aa | 27.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1647 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0582 | 0.3276 | 0.5 |
Brugia malayi | hypothetical protein | 0.0582 | 0.3276 | 0.447 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1647 | 1 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1647 | 1 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0854 | 0.4992 | 0.6721 |
Mycobacterium ulcerans | thymidylate synthase | 0.1224 | 0.7329 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1647 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.1224 | 0.7329 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.1224 | 0.7329 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1224 | 0.7329 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0854 | 0.4992 | 0.6721 |
Brugia malayi | thymidylate synthase | 0.1224 | 0.7329 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1224 | 0.7329 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0854 | 0.4992 | 0.6812 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0854 | 0.4992 | 0.6812 |
Loa Loa (eye worm) | thymidylate synthase | 0.1224 | 0.7329 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0854 | 0.4992 | 0.6812 |
Onchocerca volvulus | 0.1224 | 0.7329 | 0.5 | |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0854 | 0.4992 | 0.4235 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0854 | 0.4992 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1647 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.1224 | 0.7329 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.2 uM | Inhibitory activity against Matrix Metallo Proteinase-1(MMP-1) | ChEMBL. | No reference |
IC50 (binding) | = 3.2 uM | Inhibitory activity against Matrix Metallo Proteinase-1(MMP-1) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.