Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine receptor D3 | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D2 | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | dopamine receptor D3 | 400 aa | 392 aa | 19.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | concentrative Na+ nucleoside cotransporter | 0.0333 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0 | 0.5 |
Echinococcus granulosus | concentrative Na nucleoside cotransporter | 0.0333 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 28 | 0.0333 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0 | 0.5 |
Echinococcus granulosus | Na+ dependent nucleoside transporter | 0.0333 | 1 | 1 |
Echinococcus multilocularis | sodium:nucleoside cotransporter 2 | 0.0217 | 0.3139 | 0.3139 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 5.3 nM | Agonist activation of human dopamine receptor stimulating mitogenesis in Dopamine receptor D4-transfected CHO pro-5 cells using [3H]-thymidine as radioligand | ChEMBL. | 9191952 |
EC50 (functional) | = 5.3 nM | Agonist activation of human dopamine receptor stimulating mitogenesis in Dopamine receptor D4-transfected CHO pro-5 cells using [3H]-thymidine as radioligand | ChEMBL. | 9191952 |
Ki (binding) | = 5.64 | Binding affinity towards human dopamine receptor D2 was determined by using [3H]-spiperone as radioligand | ChEMBL. | 15808487 |
Ki (binding) | = 7.47 | Binding affinity of compound towards human dopamine receptor D4 was determined | ChEMBL. | 15808487 |
Ki (binding) | = 8.28 | Binding affinity towards human dopamine receptor D4 expressed in CHO cells was determined by using [3H]-thymidine as radioligand | ChEMBL. | 15808487 |
Ki (binding) | = 34 nM | Binding affinity for human Dopamine receptor D4 expressed in CHO K1 transfected cells using [3H]-Spiperone as radioligand | ChEMBL. | 9191952 |
Ki (binding) | = 34 nM | Binding affinity for human Dopamine receptor D4 expressed in CHO K1 transfected cells using [3H]-Spiperone as radioligand | ChEMBL. | 9191952 |
Ki (binding) | = 897 nM | Binding affinity for human Dopamine receptor D2 expressed in CHO K1 transfected cells using [3H]-Spiperone as radioligand | ChEMBL. | 9191952 |
Ki (binding) | = 897 nM | Binding affinity for human Dopamine receptor D2 expressed in CHO K1 transfected cells using [3H]-Spiperone as radioligand | ChEMBL. | 9191952 |
Ki (binding) | = 2270 nM | Binding affinity for human Dopamine receptor D3 expressed in CHO K1 transfected cells using [3H]-Spiperone as radioligand | ChEMBL. | 9191952 |
Ki (binding) | = 2270 nM | Binding affinity for human Dopamine receptor D3 expressed in CHO K1 transfected cells using [3H]-Spiperone as radioligand | ChEMBL. | 9191952 |
Log 1/Ki (binding) | = 5.64 | Binding affinity towards human dopamine receptor D2 was determined by using [3H]-spiperone as radioligand | ChEMBL. | 15808487 |
Log 1/Ki (binding) | = 6.05 | Binding affinity towards dopamine receptor D2 was determined by using [3H]-spiperone as radioligand | ChEMBL. | 15808487 |
Log 1/Ki (binding) | = 7.47 | Binding affinity of compound towards human dopamine receptor D4 was determined | ChEMBL. | 15808487 |
Log 1/Ki (binding) | = 8.28 | Binding affinity towards human dopamine receptor D4 expressed in CHO cells was determined by using [3H]-thymidine as radioligand | ChEMBL. | 15808487 |
Max effect (functional) | = 98 % | Agonist action was estimated by measuring the cellular uptake of [3H]-thymidine by comparing with the full Dopamine receptor D4 agonist quinpirole (100%) | ChEMBL. | 9191952 |
Max effect (functional) | = 98 % | Agonist action was estimated by measuring the cellular uptake of [3H]-thymidine by comparing with the full Dopamine receptor D4 agonist quinpirole (100%) | ChEMBL. | 9191952 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.