Detailed information for compound 719597

Basic information

Technical information
  • TDR Targets ID: 719597
  • Name: 5-chloro-N-[4-(4-methoxyphenyl)-1,3-thiazol-2 -yl]thiophene-2-carboxamide
  • MW: 350.843 | Formula: C15H11ClN2O2S2
  • H donors: 1 H acceptors: 2 LogP: 4.73 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1csc(n1)NC(=O)c1ccc(s1)Cl
  • InChi: 1S/C15H11ClN2O2S2/c1-20-10-4-2-9(3-5-10)11-8-21-15(17-11)18-14(19)12-6-7-13(16)22-12/h2-8H,1H3,(H,17,18,19)
  • InChiKey: KNALWEKKKAJFCG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-chloro-N-[4-(4-methoxyphenyl)thiazol-2-yl]thiophene-2-carboxamide
  • 5-chloro-N-[4-(4-methoxyphenyl)-2-thiazolyl]-2-thiophenecarboxamide
  • ZINC01053787
  • IVK/9415988

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.2106 0.6873
Entamoeba histolytica hypothetical protein 0.0035 0.2106 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.2906 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0785 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.2906 1
Loa Loa (eye worm) hypothetical protein 0.0148 1 1
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.1354 0.1043
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0347 0.4422
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0799 0.5
Giardia lamblia Sgs1 DNA helicase, putative 0.001 0.0347 0.5
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0555 0.2636
Schistosoma mansoni hypothetical protein 0.0035 0.2106 0.7247
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0993 0.3417
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.2906 0.2651
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.1354 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.2906 1
Treponema pallidum ATP-dependent DNA helicase 0.0005 0 0.5
Entamoeba histolytica hypothetical protein 0.0035 0.2106 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0555 0.5
Onchocerca volvulus 0.0148 1 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.2906 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.2106 0.6873
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.2906 1
Echinococcus granulosus bloom syndrome protein 0.0024 0.1354 0.3934
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.1146 1
Loa Loa (eye worm) hypothetical protein 0.0123 0.827 0.8207
Loa Loa (eye worm) RecQ helicase 0.0024 0.1354 0.1043
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0555 0.5
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0347 0.4422
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.2906 1
Echinococcus multilocularis bloom syndrome protein 0.0024 0.1354 0.3934
Schistosoma mansoni DNA helicase recq5 0.001 0.0347 0.1194
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.2906 0.2651
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.2906 1
Schistosoma mansoni DNA helicase recq1 0.001 0.0347 0.1194
Entamoeba histolytica hypothetical protein 0.0035 0.2106 1
Brugia malayi hypothetical protein 0.0035 0.2106 0.1822
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.1354 1
Entamoeba histolytica hypothetical protein 0.0035 0.2106 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0555 0.5
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.2106 0.7247

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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