Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | hypothetical protein | 0.0586 | 0.4684 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0139 | 0.0833 | 0.0833 |
Echinococcus multilocularis | tumor susceptibility gene 101 protein | 0.1202 | 1 | 1 |
Schistosoma mansoni | tsg101-related | 0.0818 | 0.6686 | 0.8088 |
Schistosoma mansoni | tsg101-related | 0.1001 | 0.8267 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0384 | 0.2951 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0201 | 0.137 | 0.205 |
Trypanosoma cruzi | Vps23 core domain containing protein, putative | 0.0384 | 0.2951 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0201 | 0.137 | 0.205 |
Schistosoma mansoni | hypothetical protein | 0.0198 | 0.1347 | 0.1629 |
Schistosoma mansoni | hypothetical protein | 0.0198 | 0.1347 | 0.1629 |
Echinococcus granulosus | geminin | 0.0198 | 0.1347 | 0.1347 |
Schistosoma mansoni | tsg101-related | 0.1001 | 0.8267 | 1 |
Entamoeba histolytica | tumor susceptibility gene 101 protein, putative | 0.0818 | 0.6686 | 1 |
Trypanosoma brucei | Vps23 core domain containing protein, putative | 0.0384 | 0.2951 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0201 | 0.137 | 0.205 |
Echinococcus multilocularis | geminin | 0.0198 | 0.1347 | 0.1347 |
Entamoeba histolytica | hypothetical protein | 0.0201 | 0.137 | 0.205 |
Loa Loa (eye worm) | hypothetical protein | 0.1202 | 1 | 0.5 |
Echinococcus granulosus | tumor susceptibility gene 101 protein | 0.1202 | 1 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0119 | 0.0666 | 0.0666 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0139 | 0.0833 | 0.1007 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.6 uM | Inhibitory concentration of the compound against E. coli heat-labile enterotoxin (LT) binding to ganglioside GD1b was determined by ELISA assay | ChEMBL. | 10346930 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.