Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium inwardly-rectifying channel, subfamily J, member 11 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0661 | 0.1097 | 0.1841 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.1466 | 0.514 | 0.9188 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0502 | 0.0296 | 0.0038 |
Schistosoma mansoni | tyrosine kinase | 0.0496 | 0.027 | 0.0033 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0661 | 0.1097 | 0.1841 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0934 | 0.2466 | 0.2266 |
Mycobacterium ulcerans | hydrolase | 0.0805 | 0.182 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0496 | 0.027 | 0.0033 |
Echinococcus multilocularis | disintegrin and metalloproteinase | 0.1148 | 0.3543 | 0.3371 |
Loa Loa (eye worm) | hypothetical protein | 0.0732 | 0.1454 | 0.2441 |
Loa Loa (eye worm) | hypothetical protein | 0.0661 | 0.1097 | 0.1841 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.2434 | 1 | 1 |
Brugia malayi | Hemopexin family protein | 0.0897 | 0.2279 | 0.2434 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0805 | 0.182 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0502 | 0.0296 | 0.0114 |
Schistosoma mansoni | hypothetical protein | 0.0897 | 0.2279 | 0.6153 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0502 | 0.0296 | 0.0038 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0639 | 0.0985 | 0.221 |
Loa Loa (eye worm) | matrixin family protein | 0.1629 | 0.5957 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0805 | 0.182 | 0.3056 |
Brugia malayi | hypothetical protein | 0.0715 | 0.1366 | 0.0554 |
Loa Loa (eye worm) | matrixin family protein | 0.1466 | 0.514 | 0.8629 |
Onchocerca volvulus | Matrilysin homolog | 0.1538 | 0.5497 | 1 |
Echinococcus granulosus | disintegrin and metalloproteinase | 0.1148 | 0.3543 | 0.3371 |
Brugia malayi | Matrixin family protein | 0.1629 | 0.5957 | 1 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.1126 | 0.343 | 0.3255 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0934 | 0.2466 | 0.414 |
Schistosoma mansoni | dihydroceramide desaturase | 0.1148 | 0.3543 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0502 | 0.0296 | 0.0038 |
Loa Loa (eye worm) | disintegrin family protein | 0.0783 | 0.1706 | 0.2865 |
Schistosoma mansoni | tyrosine kinase | 0.0934 | 0.2466 | 0.6722 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0805 | 0.182 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1395 | 0.478 | 0.8025 |
Echinococcus multilocularis | adam | 0.0715 | 0.1366 | 0.1136 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0934 | 0.2466 | 0.2818 |
Echinococcus granulosus | adam 17 protease | 0.1004 | 0.2821 | 0.263 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0805 | 0.182 | 0.1489 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.1126 | 0.343 | 0.3255 |
Echinococcus granulosus | adam | 0.0715 | 0.1366 | 0.1136 |
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0715 | 0.1366 | 0.337 |
Schistosoma mansoni | tyrosine kinase | 0.0496 | 0.027 | 0.0033 |
Echinococcus multilocularis | adam 17 protease | 0.0639 | 0.0985 | 0.0745 |
Onchocerca volvulus | 0.0897 | 0.2279 | 0.2688 | |
Loa Loa (eye worm) | reprolysin | 0.0494 | 0.0259 | 0.0435 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0732 | 0.1454 | 0.364 |
Brugia malayi | Disintegrin family protein | 0.1148 | 0.3543 | 0.5033 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0794 | 0.1765 | 0.4587 |
Schistosoma mansoni | tyrosine kinase | 0.0502 | 0.0296 | 0.0114 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0934 | 0.2466 | 0.2266 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 0.306 uM | Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17 | ChEMBL. | 12729655 |
EC50 (binding) | = 0.306 uM | Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17 | ChEMBL. | 12729655 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.