Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosylhomocysteinase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0156 | 0.0143 | 1 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0156 | 0.0143 | 0.047 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.0263 | 0.1251 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0156 | 0.0143 | 0.0073 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0156 | 0.0143 | 0.2295 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0156 | 0.0143 | 0.3214 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.0126 | 0.007 | 0.1128 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.0156 | 0.0143 | 0.5 |
Trypanosoma cruzi | Enriched in surface-labeled proteome protein 12 | 0.022 | 0.0296 | 1 |
Trypanosoma cruzi | Enriched in surface-labeled proteome protein 12 | 0.022 | 0.0296 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0156 | 0.0143 | 0.0073 |
Brugia malayi | Amyloid A4 extracellular domain containing protein | 0.0976 | 0.2109 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.022 | 0.0296 | 1 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.0156 | 0.0143 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0413 | 0.0759 | 0.4467 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0156 | 0.0143 | 1 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0156 | 0.0143 | 0.3214 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.0156 | 0.0143 | 0.5 |
Trichomonas vaginalis | Sialidase-1 precursor, putative | 0.4267 | 1 | 1 |
Trypanosoma brucei | Enriched in surface-labeled proteome protein 12 | 0.022 | 0.0296 | 1 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0156 | 0.0143 | 1 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0156 | 0.0143 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1091 | 0.2384 | 0.233 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0156 | 0.0143 | 1 |
Brugia malayi | Adenosylhomocysteinase | 0.0156 | 0.0143 | 0.0356 |
Schistosoma mansoni | alzheimer's disease beta-amyloid related | 0.0356 | 0.0622 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0769 | 0.1613 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0156 | 0.0143 | 0.3214 |
Trypanosoma brucei | hypothetical protein, conserved | 0.022 | 0.0296 | 1 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0156 | 0.0143 | 1 |
Trypanosoma cruzi | Enriched in surface-labeled proteome protein 12 | 0.022 | 0.0296 | 1 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0156 | 0.0143 | 1 |
Trypanosoma cruzi | Enriched in surface-labeled proteome protein 12 | 0.022 | 0.0296 | 1 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0156 | 0.0143 | 1 |
Trypanosoma cruzi | Enriched in surface-labeled proteome protein 12 | 0.022 | 0.0296 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | uM | Evaluated for the 50% inhibition of bovine-liver S-Adenosylhomocysteine (AdoHcy) hydrolase; Not applicable | ChEMBL. | 3411600 |
IC50 (binding) | NA 0 uM | Evaluated for the 50% inhibition of bovine-liver S-Adenosylhomocysteine (AdoHcy) hydrolase; Not applicable | ChEMBL. | 3411600 |
IC50 (binding) | = 200 uM | Evaluated for the 50% inhibition of S-Adenosylhomocysteine (AdoHcy) hydrolase L929 lysate from murine L-929 cells | ChEMBL. | 3411600 |
IC50 (binding) | = 200 uM | Evaluated for the 50% inhibition of S-Adenosylhomocysteine (AdoHcy) hydrolase L929 lysate from murine L-929 cells | ChEMBL. | 3411600 |
IC50 (functional) | = 300 uM | Evaluated for 50% plaque inhibition of vaccinia virus replication in murine L929 cells | ChEMBL. | 3411600 |
Ki (binding) | = 200 nM | Inhibition against bovine-liver S-Adenosylhomocysteine (AdoHcy) hydrolase | ChEMBL. | 3411600 |
Ki (binding) | = 200 nM | Inhibition against bovine-liver S-Adenosylhomocysteine (AdoHcy) hydrolase | ChEMBL. | 3411600 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.