Detailed information for compound 721420

Basic information

Technical information
  • TDR Targets ID: 721420
  • Name: 4-[2-(2,6-dimethylmorpholin-4-yl)ethoxy]benza ldehyde
  • MW: 263.332 | Formula: C15H21NO3
  • H donors: 0 H acceptors: 1 LogP: 1.89 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=Cc1ccc(cc1)OCCN1CC(C)OC(C1)C
  • InChi: 1S/C15H21NO3/c1-12-9-16(10-13(2)19-12)7-8-18-15-5-3-14(11-17)4-6-15/h3-6,11-13H,7-10H2,1-2H3
  • InChiKey: FWGFRHFIGCOVLE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[2-(2,6-dimethyl-4-morpholinyl)ethoxy]benzaldehyde

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0017 0.0514 0.0514
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0514 0.0291
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0141 0.0444
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0514 0.043
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0437 0.5
Brugia malayi hypothetical protein 0.0016 0.043 0.043
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0437 0.5
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.3099 1
Loa Loa (eye worm) glutathione reductase 0.0046 0.2237 0.2237
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.3099 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0864 0.0864
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.5766 0.8837
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0175 1 1
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.2237 1
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0951 0.3068
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.6468 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.3099 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.3173 0.3838
Loa Loa (eye worm) hypothetical protein 0.0023 0.0864 0.0864
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0141 0.0444
Treponema pallidum NADH oxidase 0.0016 0.0437 0.5
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.2237 0.7051
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.6468 1
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.2237 0.2237
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.3173 0.3173
Brugia malayi hypothetical protein 0.0024 0.0951 0.0951
Brugia malayi Thioredoxin reductase 0.0046 0.2237 0.2237
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0458 0.0035
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0864 0.1602
Brugia malayi TAR-binding protein 0.0061 0.3173 0.3173
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.3099 0.3749
Leishmania major hypothetical protein, conserved 0.0024 0.0951 0.193
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0437 0.1377
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0514 0.043
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.5766 0.8837
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0864 0.1602
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0437 0.141
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.3099 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0437 0.5
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0864 0.1602
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0864 0.1602
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0864 0.5
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0951 0.2855
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.2237 0.2985
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.5766 0.8837
Loa Loa (eye worm) hypothetical protein 0.0017 0.0514 0.0514
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.3099 0.3749
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.3173 0.3173
Plasmodium vivax glutathione reductase, putative 0.0046 0.2237 1
Trypanosoma brucei trypanothione reductase 0.0046 0.2237 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.5766 0.8749
Loa Loa (eye worm) hypothetical protein 0.0017 0.0514 0.0514
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.2237 0.7051
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0437 0.5
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0864 0.5
Plasmodium falciparum thioredoxin reductase 0.0046 0.2237 1
Schistosoma mansoni hypothetical protein 0.0011 0.0141 0.0171
Loa Loa (eye worm) RNA binding protein 0.0061 0.3173 0.3173
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.6468 1
Echinococcus granulosus tar DNA binding protein 0.0061 0.3173 1
Brugia malayi RNA binding protein 0.0061 0.3173 0.3173
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.5766 0.8837
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0864 0.1602
Brugia malayi glutathione reductase 0.0046 0.2237 0.2237
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0864 0.1602
Leishmania major trypanothione reductase 0.0046 0.2237 0.6761
Mycobacterium tuberculosis Probable reductase 0.0104 0.5766 0.8837
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0864 0.1602
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0514 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0514 0.0514
Schistosoma mansoni tar DNA-binding protein 0.0061 0.3173 0.3838
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0951 0.2855
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0951 0.2855
Loa Loa (eye worm) hypothetical protein 0.0017 0.0514 0.0514
Schistosoma mansoni tar DNA-binding protein 0.0061 0.3173 0.3838
Schistosoma mansoni tar DNA-binding protein 0.0061 0.3173 0.3838
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0514 0.0128
Onchocerca volvulus 0.0023 0.0864 0.0864
Schistosoma mansoni tar DNA-binding protein 0.0061 0.3173 0.3838
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0437 0.0437
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0437 0.5
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0437 0.141
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0864 0.0864
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.3099 0.9768
Toxoplasma gondii thioredoxin reductase 0.0046 0.2237 0.7218
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0864 0.1602
Loa Loa (eye worm) TAR-binding protein 0.0061 0.3173 0.3173
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0864 0.1602
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0864 0.0707
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0864 0.5
Loa Loa (eye worm) hypothetical protein 0.0023 0.0864 0.0864
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0184 0.0184
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0437 0.0529
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0951 0.2855
Loa Loa (eye worm) hypothetical protein 0.0175 1 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0458 0.0035
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0951 0.2855
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.6468 1
Mycobacterium ulcerans hypothetical protein 0.0023 0.0864 0.1602
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0864 0.0864
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0437 0.1377
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.2237 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0864 0.0707
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0951 0.2855
Echinococcus multilocularis tar DNA binding protein 0.0061 0.3173 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0458 0.0035
Loa Loa (eye worm) hypothetical protein 0.0023 0.0864 0.0864
Loa Loa (eye worm) hypothetical protein 0.0024 0.0951 0.0951
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.3099 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.3099 0.4415
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0184 0.0184
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.5766 0.8837
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.3099 0.9768
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0458 0.0035
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0864 0.1602
Plasmodium falciparum glutathione reductase 0.0046 0.2237 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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