Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0144 | 0 | 0.5 | |
Trypanosoma brucei | hypothetical protein, conserved | 0.0884 | 1 | 1 |
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.0289 | 0.1956 | 1 |
Onchocerca volvulus | 0.0144 | 0 | 0.5 | |
Onchocerca volvulus | 0.0144 | 0 | 0.5 | |
Onchocerca volvulus | 0.0144 | 0 | 0.5 | |
Onchocerca volvulus | 0.0144 | 0 | 0.5 | |
Onchocerca volvulus | 0.0144 | 0 | 0.5 | |
Onchocerca volvulus | 0.0144 | 0 | 0.5 | |
Trypanosoma cruzi | Enriched in surface-labeled proteome protein 12 | 0.0884 | 1 | 1 |
Trypanosoma brucei | Enriched in surface-labeled proteome protein 12 | 0.0884 | 1 | 1 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0144 | 0 | 0.5 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0289 | 0.1956 | 1 |
Entamoeba histolytica | ubiquitin-conjugating enzyme family protein | 0.0289 | 0.1956 | 0.5 |
Brugia malayi | Ubiquitin conjugating enzyme protein 13 | 0.0289 | 0.1956 | 1 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.0289 | 0.1956 | 0.5 |
Onchocerca volvulus | 0.0144 | 0 | 0.5 | |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.0289 | 0.1956 | 0.5 |
Onchocerca volvulus | 0.0144 | 0 | 0.5 | |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.0289 | 0.1956 | 0.5 |
Onchocerca volvulus | 0.0144 | 0 | 0.5 | |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.0289 | 0.1956 | 1 |
Trypanosoma cruzi | Enriched in surface-labeled proteome protein 12 | 0.0884 | 1 | 1 |
Onchocerca volvulus | 0.0144 | 0 | 0.5 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0144 | 0 | 0.5 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0289 | 0.1956 | 0.5 |
Onchocerca volvulus | 0.0144 | 0 | 0.5 | |
Trypanosoma cruzi | Enriched in surface-labeled proteome protein 12 | 0.0884 | 1 | 1 |
Onchocerca volvulus | 0.0144 | 0 | 0.5 | |
Onchocerca volvulus | 0.0144 | 0 | 0.5 | |
Onchocerca volvulus | 0.0144 | 0 | 0.5 | |
Onchocerca volvulus | 0.0144 | 0 | 0.5 | |
Trypanosoma cruzi | Enriched in surface-labeled proteome protein 12 | 0.0884 | 1 | 1 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.0289 | 0.1956 | 0.5 |
Trypanosoma cruzi | Enriched in surface-labeled proteome protein 12 | 0.0884 | 1 | 1 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0289 | 0.1956 | 1 |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.0289 | 0.1956 | 1 |
Onchocerca volvulus | 0.0144 | 0 | 0.5 | |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.0289 | 0.1956 | 1 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0289 | 0.1956 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.648 uM | Binding affinity against adenosine A1 receptor from rat brain. | ChEMBL. | 7752196 |
Ki (binding) | = 0.974 uM | Binding affinity against adenosine A3 receptor from rat brain. | ChEMBL. | 7752196 |
Ki (binding) | = 3.56 uM | Binding affinity against adenosine A2A receptor from rat brain. | ChEMBL. | 7752196 |
Ratio (binding) | = 0.67 | Ratio of the binding affinnities against rat brain A1 and A3 receptors, KiA1/KiA3. | ChEMBL. | 7752196 |
Ratio (binding) | = 3.7 | Ratio of the binding affinnities against rat brain A2a and A3 receptors, KiA2a/KiA3. | ChEMBL. | 7752196 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.