Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | oxidoreductase-like protein | 0.0058 | 0.0109 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0058 | 0.0109 | 0.0109 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0058 | 0.0109 | 0.0109 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.0062 | 0.0158 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0748 | 1 | 1 |
Echinococcus granulosus | Bcl 2 ous antagonist:killer | 0.0055 | 0.0062 | 0.0068 |
Leishmania major | pteridine reductase 1 | 0.0058 | 0.0109 | 1 |
Schistosoma mansoni | bcl-2 homologous antagonist/killer (bak) | 0.0055 | 0.0062 | 0.0158 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.0062 | 0.0158 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0748 | 1 | 1 |
Mycobacterium ulcerans | 3-alpha-hydroxysteroid dehydrogenase | 0.0058 | 0.0109 | 0.0109 |
Schistosoma mansoni | apoptosis regulator bax | 0.0055 | 0.0062 | 0.0158 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0058 | 0.0109 | 1 |
Loa Loa (eye worm) | dual specificity phosphatase | 0.0323 | 0.3906 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0748 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.0062 | 0.0158 |
Onchocerca volvulus | 0.0058 | 0.0109 | 0.028 | |
Schistosoma mansoni | dual specificity protein phosphatase | 0.0323 | 0.3906 | 1 |
Echinococcus granulosus | dual specificity protein phosphatase | 0.0323 | 0.3906 | 0.4271 |
Onchocerca volvulus | 0.0323 | 0.3906 | 1 | |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.0688 | 0.9146 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0748 | 1 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0748 | 1 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0748 | 1 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0748 | 1 | 1 |
Brugia malayi | Apoptosis regulator proteins, Bcl-2 family protein | 0.0055 | 0.0062 | 0.0158 |
Giardia lamblia | Dual specificity phosphatase, catalytic | 0.0323 | 0.3906 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0062 | 0.0158 |
Echinococcus multilocularis | dual specificity protein phosphatase | 0.0323 | 0.3906 | 0.4271 |
Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0058 | 0.0109 | 0.0109 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0058 | 0.0109 | 0.0109 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0748 | 1 | 1 |
Brugia malayi | Dual specificity phosphatase, catalytic domain containing protein | 0.0323 | 0.3906 | 1 |
Loa Loa (eye worm) | apoptosis regulator protein | 0.0055 | 0.0062 | 0.0158 |
Plasmodium vivax | multidrug resistance-associated protein 1, putative | 0.0287 | 0.3391 | 0.3391 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0058 | 0.0109 | 0.0109 |
Echinococcus granulosus | EGFP:Bcl2 fusion protein | 0.0688 | 0.9146 | 1 |
Echinococcus multilocularis | Bcl 2 ous antagonist:killer | 0.0055 | 0.0062 | 0.0068 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0051 | 0 | 0.5 |
Leishmania major | oxidoreductase-like protein | 0.0058 | 0.0109 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.