Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 1 (interstitial collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 8 (neutrophil collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 13 (collagenase 3) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Matrixin family protein | matrix metallopeptidase 1 (interstitial collagenase) | 403 aa | 401 aa | 27.7 % |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 8 (neutrophil collagenase) | 467 aa | 467 aa | 33.4 % |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 13 (collagenase 3) | 471 aa | 448 aa | 34.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.195 | 1 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.195 | 1 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.195 | 1 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.195 | 1 | 1 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0132 | 0.002 | 1 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0132 | 0.002 | 0.0573 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0287 | 0.0871 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0175 | 0.0256 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0175 | 0.0256 | 1 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0132 | 0.002 | 0.0573 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0132 | 0.002 | 1 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0132 | 0.002 | 0.0226 |
Loa Loa (eye worm) | matrixin family protein | 0.0191 | 0.0343 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.195 | 1 | 1 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0132 | 0.002 | 0.5 |
Trypanosoma brucei | pteridine reductase 1 | 0.0132 | 0.002 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0132 | 0.002 | 0.0573 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0132 | 0.002 | 1 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0132 | 0.002 | 1 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0132 | 0.002 | 0.0226 |
Trichomonas vaginalis | hypothetical protein | 0.195 | 1 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.195 | 1 | 1 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0132 | 0.002 | 1 |
Leishmania major | pteridine reductase 1 | 0.0132 | 0.002 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.002 | 0.0573 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0132 | 0.002 | 0.0573 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0287 | 0.0871 | 1 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0132 | 0.002 | 0.0573 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0132 | 0.002 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0175 | 0.0256 | 0.7472 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.195 | 1 | 1 |
Leishmania major | oxidoreductase-like protein | 0.0132 | 0.002 | 1 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0132 | 0.002 | 0.5 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0132 | 0.002 | 1 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0132 | 0.002 | 1 |
Brugia malayi | Matrixin family protein | 0.0191 | 0.0343 | 1 |
Schistosoma mansoni | dihydropteridine reductase | 0.0132 | 0.002 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 22 nM | Inhibition of human recombinant matrix metalloproteinase-13 (hMMP-13) | ChEMBL. | 10406637 |
IC50 (binding) | = 22 nM | Inhibition of human recombinant matrix metalloproteinase-13 (hMMP-13) | ChEMBL. | 10406637 |
IC50 (binding) | = 585 nM | Inhibition of human recombinant matrix metalloproteinase-8 (hMMP-8) | ChEMBL. | 10406637 |
IC50 (binding) | = 585 nM | Inhibition of human recombinant matrix metalloproteinase-8 (hMMP-8) | ChEMBL. | 10406637 |
IC50 (binding) | = 1000 nM | Inhibition of human recombinant matrix metalloproteinase-1 (hMMP-1) | ChEMBL. | 10406637 |
IC50 (binding) | = 1000 nM | Inhibition of human recombinant matrix metalloproteinase-1 (hMMP-1) | ChEMBL. | 10406637 |
Selectivity (binding) | = 45 | Selectivity for hMMP-13 over hMMP-1 | ChEMBL. | 10406637 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.