Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Plasmodium falciparum | plasmepsin II | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0063 | 0.1805 | 0.2122 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0063 | 0.1805 | 0.1302 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0035 | 0.0361 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0063 | 0.1805 | 0.2122 |
Loa Loa (eye worm) | inositol-1 | 0.0039 | 0.0578 | 0.1827 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0063 | 0.1805 | 0.1302 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0039 | 0.0578 | 0.1827 |
Plasmodium falciparum | plasmepsin IV | 0.0088 | 0.3164 | 1 |
Echinococcus multilocularis | kinesin family 1 | 0.0218 | 1 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0039 | 0.0578 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0578 | 0.5 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0063 | 0.1805 | 0.1302 |
Brugia malayi | Inositol-1 | 0.0039 | 0.0578 | 0.3203 |
Schistosoma mansoni | jumonji domain containing protein | 0.0063 | 0.1805 | 0.2122 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0088 | 0.3164 | 1 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0088 | 0.3164 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.0578 | 0.068 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0039 | 0.0578 | 0.5 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0035 | 0.0361 | 0.5 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0088 | 0.3164 | 0.2745 |
Plasmodium falciparum | plasmepsin VI | 0.0088 | 0.3164 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0088 | 0.3164 | 0.3719 |
Plasmodium falciparum | plasmepsin I | 0.0088 | 0.3164 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0088 | 0.3164 | 0.3719 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0088 | 0.3164 | 1 |
Schistosoma mansoni | hypothetical protein | 0.019 | 0.8507 | 1 |
Plasmodium vivax | plasmepsin IV, putative | 0.0088 | 0.3164 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0039 | 0.0578 | 0.5 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0088 | 0.3164 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0578 | 0.5 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0063 | 0.1805 | 0.1302 |
Plasmodium falciparum | plasmepsin II | 0.0088 | 0.3164 | 1 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0088 | 0.3164 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0063 | 0.1805 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0578 | 0.5 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0088 | 0.3164 | 0.2745 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.3164 | 1 |
Giardia lamblia | Kinesin-5 | 0.0028 | 0 | 0.5 |
Brugia malayi | jmjC domain containing protein | 0.0063 | 0.1805 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0088 | 0.3164 | 0.3719 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0578 | 0.5 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.0578 | 0.068 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0063 | 0.1805 | 0.5705 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7 uM | Inhibition of recombinant Plasmodium falciparum plasmepsin 2 expressed in Escherichia coli using DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS as substrate incubated for 40 mins prior to substrate addition measured after 10 mins by FRET-based fluorometric analysis | ChEMBL. | 23466235 |
Inhibition (binding) | = 60.56 % | Inhibition of recombinant Plasmodium falciparum plasmepsin 2 expressed in Escherichia coli using DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS as substrate at 10 uM incubated for 40 mins prior to substrate addition measured after 10 mins by FRET-based fluorometric analysis | ChEMBL. | 23466235 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.