TDR Targets

Basic information

Technical information

TDR Targets ID: 736243
Name: N-[(4-propan-2-ylphenyl)methylideneamino]bicy clo[4.1.0]heptane-7-carboxamide
MW: 284.396 | Formula: C18H24N2O
H donors: 1 H acceptors: 1 LogP: 4.5 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CC(c1ccc(cc1)/C=N/NC(=O)C1C2C1CCCC2)C
InChi: 1S/C18H24N2O/c1-12(2)14-9-7-13(8-10-14)11-19-20-18(21)17-15-5-3-4-6-16(15)17/h7-12,15-17H,3-6H2,1-2H3,(H,20,21)/b19-11+
InChiKey: KUCIEBARWOMZNS-YBFXNURJSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[(4-isopropylphenyl)methyleneamino]norcarane-7-carboxamide
N-[(4-isopropylphenyl)methyleneamino]-7-norcaranecarboxamide
N-[(4-isopropylbenzylidene)amino]norcarane-7-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0038	0.0093	0.0094
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0038	0.0093	0.0074
Schistosoma mansoni	hypothetical protein	0.0122	0.2228	0.2243
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0426	1	1
Plasmodium vivax	thioredoxin reductase, putative	0.0055	0.0527	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.014	0.269	0.5535
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0068	0.0852	0.084
Schistosoma mansoni	serine/threonine protein kinase	0.0068	0.0852	0.0858
Schistosoma mansoni	nuclear hormone receptor	0.0038	0.0093	0.0094
Echinococcus multilocularis	jun protein	0.0082	0.1221	0.1212
Schistosoma mansoni	calcium-activated potassium channel	0.0402	0.9405	0.9469
Schistosoma mansoni	hypothetical protein	0.0035	0.002	0.002
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0038	0.0093	0.0074
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0038	0.0093	0.0074
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0038	0.0093	0.0074
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0038	0.0093	0.0611
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0038	0.0093	0.0074
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0068	0.0852	0.0834
Echinococcus granulosus	geminin	0.0122	0.2228	0.2228
Brugia malayi	nuclear receptor NHR-88	0.0038	0.0093	0.0611
Brugia malayi	ecdysteroid receptor	0.0038	0.0093	0.0611
Brugia malayi	Nuclear hormone receptor-like 1	0.0038	0.0093	0.0611
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0426	1	1
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0114	0.2046	0.2045
Onchocerca volvulus		0.0065	0.077	0.8915
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0126	0.2332	0.4618
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0402	0.3179
Schistosoma mansoni	retinoic acid receptor RXR	0.0135	0.2561	0.2579
Loa Loa (eye worm)	hypothetical protein	0.0423	0.9932	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0426	1	1
Loa Loa (eye worm)	glutathione reductase	0.0055	0.0527	0.0441
Brugia malayi	nuclear hormone receptor	0.0038	0.0093	0.0611
Plasmodium falciparum	glutathione reductase	0.0055	0.0527	0.5
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0426	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0038	0.0093	0.0611
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0135	0.2561	0.2564
Schistosoma mansoni	thyroid hormone receptor	0.0038	0.0093	0.0094
Brugia malayi	bZIP transcription factor family protein	0.0082	0.1221	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0056	0.0546	0.0531
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0038	0.0093	0.0611
Schistosoma mansoni	hypothetical protein	0.0067	0.0828	0.0833
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0038	0.0093	0.0074
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0126	0.2332	0.4618
Treponema pallidum	fructose-bisphosphate aldolase	0.0426	1	0.5
Schistosoma mansoni	thyroid hormone receptor	0.0038	0.0093	0.0094
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0038	0.0093	0.0611
Loa Loa (eye worm)	hypothetical protein	0.0212	0.454	0.452
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0126	0.2332	0.4618
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0038	0.0093	0.0094
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0038	0.0093	0.0611
Schistosoma mansoni	coup transcription factor	0.0038	0.0093	0.0094
Brugia malayi	photoreceptor-specific nuclear receptor	0.0038	0.0093	0.0611
Schistosoma mansoni	RAR-like nuclear receptor	0.0038	0.0093	0.0094
Schistosoma mansoni	jun-related protein	0.0067	0.0828	0.0833
Schistosoma mansoni	hypothetical protein	0.0423	0.9932	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0426	1	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0402	0.0314
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0082	0.1221	0.1212
Brugia malayi	Thioredoxin reductase	0.0055	0.0527	0.4225
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0038	0.0093	0.0611
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0038	0.0093	0.0094
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0038	0.0093	0.0074
Loa Loa (eye worm)	hypothetical protein	0.005	0.0402	0.0314
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0208	0.4434	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0126	0.2332	0.4618
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0038	0.0093	0.0074
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0038	0.0093	0.0611
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.014	0.269	0.1705
Brugia malayi	hypothetical protein	0.0065	0.077	0.6243
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0038	0.0093	0.0611
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0208	0.4434	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0038	0.0093	0.0611
Loa Loa (eye worm)	hypothetical protein	0.008	0.1164	0.1088
Brugia malayi	steroid hormone receptor	0.0038	0.0093	0.0611
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0402	0.3179
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0038	0.0093	0.0611
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0038	0.0093	0.0611
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0068	0.0852	0.0771
Echinococcus multilocularis	small conductance calcium activated potassium	0.0423	0.9932	1
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0068	0.0852	1
Echinococcus granulosus	jun protein	0.0082	0.1221	0.1212
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0038	0.0093	0.0611
Giardia lamblia	Fructose-bisphosphate aldolase	0.0426	1	1
Brugia malayi	serine/threonine-protein kinase plk-2	0.0068	0.0852	0.6928
Plasmodium falciparum	thioredoxin reductase	0.0055	0.0527	0.5
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.002	0.002
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0426	1	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.014	0.269	0.5535
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.014	0.269	0.5535
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0426	1	1
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0208	0.4434	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0038	0.0093	0.0094
Mycobacterium tuberculosis	Probable reductase	0.0126	0.2332	0.4618
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0038	0.0093	0.0094
Echinococcus multilocularis	geminin	0.0122	0.2228	0.2228
Brugia malayi	glutathione reductase	0.0055	0.0527	0.4225
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0038	0.0093	0.0074
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0068	0.0852	0.084
Toxoplasma gondii	thioredoxin reductase	0.0055	0.0527	0.5
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0082	0.1221	0.1212
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0126	0.2332	0.4618
Schistosoma mansoni	calcium-activated potassium channel	0.0423	0.9932	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0038	0.0093	0.0074
Loa Loa (eye worm)	thioredoxin reductase	0.0055	0.0527	0.0441
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0038	0.0093	0.0074
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0038	0.0093	0.0611
Echinococcus granulosus	FTZ F1 alpha	0.0038	0.0093	0.0074
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0068	0.0852	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0038	0.0093	0.0094
Trypanosoma cruzi	polo-like protein kinase, putative	0.0068	0.0852	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0038	0.0093	0.0074
Plasmodium vivax	glutathione reductase, putative	0.0055	0.0527	0.5
Echinococcus granulosus	small conductance calcium activated potassium	0.0423	0.9932	1
Trypanosoma cruzi	polo-like protein kinase, putative	0.0068	0.0852	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0038	0.0093	0.0074
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0038	0.0093	0.0074
Schistosoma mansoni	hypothetical protein	0.0122	0.2228	0.2243
Echinococcus multilocularis	FTZ F1 alpha	0.0038	0.0093	0.0074
Loa Loa (eye worm)	hypothetical protein	0.019	0.3984	0.3955
Brugia malayi	Steroid receptor seven-up type 2	0.0038	0.0093	0.0611
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0426	1	1
Echinococcus granulosus	thioredoxin glutathione reductase	0.0056	0.0546	0.0531
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0038	0.0093	0.0094
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0038	0.0093	0.0074
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0426	1	1
Trypanosoma brucei	polo-like protein kinase	0.0068	0.0852	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 736243