Detailed information for compound 738934

Basic information

Technical information
  • TDR Targets ID: 738934
  • Name: STK264575
  • MW: 468.458 | Formula: C27H20N2O6
  • H donors: 0 H acceptors: 5 LogP: 3.4 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Oc1ccccc1[N+](=O)[O-])CCN1C(=O)C2C(C1=O)C1c3c(C2c2c1cccc2)cccc3
  • InChi: 1S/C27H20N2O6/c30-21(35-20-12-6-5-11-19(20)29(33)34)13-14-28-26(31)24-22-15-7-1-2-8-16(15)23(25(24)27(28)32)18-10-4-3-9-17(18)22/h1-12,22-25H,13-14H2
  • InChiKey: YNGCQFNHADZRJL-UHFFFAOYSA-N  

Network

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Synonyms

  • CBKinase1_022315
  • CBKinase1_009915

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) glycosyl hydrolase family 18 protein 0.0012 0.0197 0.0265
Loa Loa (eye worm) hypothetical protein 0.0133 0.3123 1
Brugia malayi hypothetical protein 0.0012 0.0197 0.0274
Echinococcus granulosus Hepatocellular carcinoma associated antigen 59 0.0133 0.3123 0.3072
Loa Loa (eye worm) hypothetical protein 0.0012 0.0197 0.0265
Entamoeba histolytica chitinase, putative 0.0084 0.193 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0143 0.0085
Echinococcus multilocularis Glycoside hydrolase, chitinase domain containing protein 1 0.0012 0.0197 0.0124
Schistosoma mansoni chitinase 0.0012 0.0197 0.0197
Trichomonas vaginalis chitinase, putative 0.0012 0.0197 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0143 0.0085
Brugia malayi Chitin binding Peritrophin-A domain containing protein 0.001 0.0143 0.0094
Schistosoma mansoni hypothetical protein 0.0417 1 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0608 0.163
Echinococcus multilocularis dnaJ subfamily B 0.0417 1 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0118 0.0044
Onchocerca volvulus Putative endochitinase 0.0094 0.2175 0.6817
Onchocerca volvulus Putative chitinase 0.0012 0.0197 0.0182
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.1529 0.4699
Echinococcus granulosus Glycoside hydrolase chitinase domain containing protein 1 0.0012 0.0197 0.0124
Loa Loa (eye worm) hypothetical protein 0.0012 0.0197 0.0265
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0118 0.0044
Echinococcus multilocularis cpg binding protein 0.0031 0.0648 0.0578
Onchocerca volvulus Putative endochitinase 0.0012 0.0197 0.0182
Loa Loa (eye worm) hypothetical protein 0.001 0.0143 0.0085
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.1403 0.1403
Schistosoma mansoni cpg binding protein 0.0031 0.0648 0.0648
Loa Loa (eye worm) cuticular endochitinase 0.0084 0.193 0.6029
Leishmania major chitinase 0.0084 0.193 1
Echinococcus multilocularis Hepatocellular carcinoma associated antigen 59 0.0133 0.3123 0.3072
Echinococcus granulosus cpg binding protein 0.0031 0.0648 0.0578
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.1529 0.1529
Onchocerca volvulus Putative endochitinase 0.0084 0.193 0.5995
Loa Loa (eye worm) hypothetical protein 0.001 0.0143 0.0085
Mycobacterium tuberculosis Possible chitinase 0.0071 0.163 0.5
Brugia malayi Endochitinase 0.0094 0.2175 0.6847
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0842 0.0773
Mycobacterium ulcerans chitinase/cellulase 0.0071 0.163 1
Mycobacterium ulcerans chitinase/cellulase 0.0071 0.163 1
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0842 0.0773
Schistosoma mansoni hypothetical protein 0.0133 0.3123 0.3123
Loa Loa (eye worm) chitin binding Peritrophin-A domain-containing protein 0.001 0.0143 0.0085
Loa Loa (eye worm) hypothetical protein 0.0071 0.163 0.5033
Loa Loa (eye worm) chitin binding Peritrophin-A domain-containing protein 0.001 0.0143 0.0085
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.1529 0.1465
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.1529 0.5
Brugia malayi endochitinase 0.0084 0.193 0.6032
Schistosoma mansoni cpg binding protein 0.0031 0.0648 0.0648
Brugia malayi Endochitinase 0.0012 0.0197 0.0274
Onchocerca volvulus Putative endochitinase 0.0094 0.2175 0.6817
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0074 0.0074
Onchocerca volvulus Putative endochitinase 0.0094 0.2175 0.6817
Loa Loa (eye worm) hypothetical protein 0.001 0.0143 0.0085
Loa Loa (eye worm) hypothetical protein 0.001 0.0143 0.0085
Brugia malayi Hepatocellular carcinoma-associated antigen 59 family protein 0.0133 0.3123 1
Loa Loa (eye worm) hypothetical protein 0.0133 0.3123 1
Brugia malayi Glycosyl hydrolases family 18 protein 0.0012 0.0197 0.0274
Onchocerca volvulus 0.0133 0.3123 1
Onchocerca volvulus 0.0133 0.3123 1
Brugia malayi CXXC zinc finger family protein 0.0029 0.0608 0.1638
Loa Loa (eye worm) chitinase I 0.0084 0.193 0.6029
Plasmodium vivax hypothetical protein, conserved 0.0133 0.3123 1
Brugia malayi Chitin binding Peritrophin-A domain containing protein 0.001 0.0143 0.0094
Loa Loa (eye worm) hypothetical protein 0.001 0.0143 0.0085
Brugia malayi hypothetical protein 0.0012 0.0197 0.0274
Toxoplasma gondii hypothetical protein 0.0133 0.3123 1
Onchocerca volvulus Putative endochitinase 0.0084 0.193 0.5995
Brugia malayi Chitin binding Peritrophin-A domain containing protein 0.001 0.0143 0.0094
Plasmodium falciparum conserved protein, unknown function 0.0133 0.3123 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.1529 0.7684
Loa Loa (eye worm) hypothetical protein 0.001 0.0143 0.0085
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.1529 0.4694
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.1529 0.5
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.1529 0.1465
Onchocerca volvulus 0.0029 0.0608 0.1558
Brugia malayi endochitinase 0.0094 0.2175 0.6847
Brugia malayi Glycosyl hydrolases family 18 protein 0.0012 0.0197 0.0274
Loa Loa (eye worm) microfilarial chitinase 0.0082 0.1875 0.5848
Schistosoma mansoni cpg binding protein 0.0029 0.0608 0.0608
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.1529 0.5
Brugia malayi Chitin binding Peritrophin-A domain containing protein 0.001 0.0143 0.0094

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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