Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0133 | 0.3123 | 1 | |
Brugia malayi | Glycosyl hydrolases family 18 protein | 0.0012 | 0.0197 | 0.0274 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0143 | 0.0085 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0067 | 0.1529 | 0.1465 |
Plasmodium falciparum | conserved protein, unknown function | 0.0133 | 0.3123 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 18 protein | 0.0012 | 0.0197 | 0.0265 |
Brugia malayi | endochitinase | 0.0084 | 0.193 | 0.6032 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0071 | 0.163 | 1 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0039 | 0.0842 | 0.0773 |
Brugia malayi | Chitin binding Peritrophin-A domain containing protein | 0.001 | 0.0143 | 0.0094 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0143 | 0.0085 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.0608 | 0.163 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0143 | 0.0085 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0067 | 0.1529 | 0.5 |
Loa Loa (eye worm) | microfilarial chitinase | 0.0082 | 0.1875 | 0.5848 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0118 | 0.0044 |
Onchocerca volvulus | Putative endochitinase | 0.0094 | 0.2175 | 0.6817 |
Schistosoma mansoni | hypothetical protein | 0.0133 | 0.3123 | 0.3123 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0067 | 0.1529 | 0.7684 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0118 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0197 | 0.0265 |
Leishmania major | chitinase | 0.0084 | 0.193 | 1 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0067 | 0.1529 | 0.1529 |
Mycobacterium tuberculosis | Possible chitinase | 0.0071 | 0.163 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0143 | 0.0085 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0062 | 0.1403 | 0.1403 |
Brugia malayi | hypothetical protein | 0.0012 | 0.0197 | 0.0274 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0648 | 0.0648 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0067 | 0.1529 | 0.4694 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0143 | 0.0085 |
Toxoplasma gondii | hypothetical protein | 0.0133 | 0.3123 | 1 |
Trichomonas vaginalis | chitinase, putative | 0.0012 | 0.0197 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0143 | 0.0085 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0071 | 0.163 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0031 | 0.0648 | 0.0578 |
Brugia malayi | Hepatocellular carcinoma-associated antigen 59 family protein | 0.0133 | 0.3123 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.0094 | 0.2175 | 0.6817 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0197 | 0.0265 |
Onchocerca volvulus | Putative chitinase | 0.0012 | 0.0197 | 0.0182 |
Brugia malayi | endochitinase | 0.0094 | 0.2175 | 0.6847 |
Onchocerca volvulus | Putative endochitinase | 0.0012 | 0.0197 | 0.0182 |
Echinococcus multilocularis | Glycoside hydrolase, chitinase domain containing protein 1 | 0.0012 | 0.0197 | 0.0124 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0067 | 0.1529 | 0.5 |
Loa Loa (eye worm) | cuticular endochitinase | 0.0084 | 0.193 | 0.6029 |
Plasmodium vivax | hypothetical protein, conserved | 0.0133 | 0.3123 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0648 | 0.0648 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.3123 | 1 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0417 | 1 | 1 |
Loa Loa (eye worm) | chitinase I | 0.0084 | 0.193 | 0.6029 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0608 | 0.0608 |
Onchocerca volvulus | 0.0029 | 0.0608 | 0.1558 | |
Loa Loa (eye worm) | chitin binding Peritrophin-A domain-containing protein | 0.001 | 0.0143 | 0.0085 |
Echinococcus granulosus | Hepatocellular carcinoma associated antigen 59 | 0.0133 | 0.3123 | 0.3072 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0067 | 0.1529 | 0.4699 |
Brugia malayi | Chitin binding Peritrophin-A domain containing protein | 0.001 | 0.0143 | 0.0094 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0143 | 0.0085 |
Schistosoma mansoni | hypothetical protein | 0.0417 | 1 | 1 |
Brugia malayi | Chitin binding Peritrophin-A domain containing protein | 0.001 | 0.0143 | 0.0094 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.0608 | 0.1638 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0143 | 0.0085 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0067 | 0.1529 | 0.5 |
Schistosoma mansoni | chitinase | 0.0012 | 0.0197 | 0.0197 |
Onchocerca volvulus | 0.0133 | 0.3123 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.3123 | 1 |
Loa Loa (eye worm) | chitin binding Peritrophin-A domain-containing protein | 0.001 | 0.0143 | 0.0085 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0067 | 0.1529 | 0.1465 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.163 | 0.5033 |
Echinococcus granulosus | Glycoside hydrolase chitinase domain containing protein 1 | 0.0012 | 0.0197 | 0.0124 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0074 | 0.0074 |
Echinococcus multilocularis | Hepatocellular carcinoma associated antigen 59 | 0.0133 | 0.3123 | 0.3072 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0039 | 0.0842 | 0.0773 |
Onchocerca volvulus | Putative endochitinase | 0.0084 | 0.193 | 0.5995 |
Echinococcus granulosus | cpg binding protein | 0.0031 | 0.0648 | 0.0578 |
Brugia malayi | Chitin binding Peritrophin-A domain containing protein | 0.001 | 0.0143 | 0.0094 |
Entamoeba histolytica | chitinase, putative | 0.0084 | 0.193 | 1 |
Brugia malayi | Endochitinase | 0.0094 | 0.2175 | 0.6847 |
Brugia malayi | Endochitinase | 0.0012 | 0.0197 | 0.0274 |
Brugia malayi | Glycosyl hydrolases family 18 protein | 0.0012 | 0.0197 | 0.0274 |
Brugia malayi | hypothetical protein | 0.0012 | 0.0197 | 0.0274 |
Onchocerca volvulus | Putative endochitinase | 0.0094 | 0.2175 | 0.6817 |
Onchocerca volvulus | Putative endochitinase | 0.0084 | 0.193 | 0.5995 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.