Detailed information for compound 738934

Basic information

Technical information
  • TDR Targets ID: 738934
  • Name: STK264575
  • MW: 468.458 | Formula: C27H20N2O6
  • H donors: 0 H acceptors: 5 LogP: 3.4 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Oc1ccccc1[N+](=O)[O-])CCN1C(=O)C2C(C1=O)C1c3c(C2c2c1cccc2)cccc3
  • InChi: 1S/C27H20N2O6/c30-21(35-20-12-6-5-11-19(20)29(33)34)13-14-28-26(31)24-22-15-7-1-2-8-16(15)23(25(24)27(28)32)18-10-4-3-9-17(18)22/h1-12,22-25H,13-14H2
  • InChiKey: YNGCQFNHADZRJL-UHFFFAOYSA-N  

Network

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Synonyms

  • CBKinase1_022315
  • CBKinase1_009915

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Onchocerca volvulus 0.0133 0.3123 1
Brugia malayi Glycosyl hydrolases family 18 protein 0.0012 0.0197 0.0274
Loa Loa (eye worm) hypothetical protein 0.001 0.0143 0.0085
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.1529 0.1465
Plasmodium falciparum conserved protein, unknown function 0.0133 0.3123 1
Loa Loa (eye worm) glycosyl hydrolase family 18 protein 0.0012 0.0197 0.0265
Brugia malayi endochitinase 0.0084 0.193 0.6032
Mycobacterium ulcerans chitinase/cellulase 0.0071 0.163 1
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0842 0.0773
Brugia malayi Chitin binding Peritrophin-A domain containing protein 0.001 0.0143 0.0094
Loa Loa (eye worm) hypothetical protein 0.001 0.0143 0.0085
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0608 0.163
Loa Loa (eye worm) hypothetical protein 0.001 0.0143 0.0085
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.1529 0.5
Loa Loa (eye worm) microfilarial chitinase 0.0082 0.1875 0.5848
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0118 0.0044
Onchocerca volvulus Putative endochitinase 0.0094 0.2175 0.6817
Schistosoma mansoni hypothetical protein 0.0133 0.3123 0.3123
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.1529 0.7684
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0118 0.0044
Loa Loa (eye worm) hypothetical protein 0.0012 0.0197 0.0265
Leishmania major chitinase 0.0084 0.193 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.1529 0.1529
Mycobacterium tuberculosis Possible chitinase 0.0071 0.163 0.5
Loa Loa (eye worm) hypothetical protein 0.001 0.0143 0.0085
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.1403 0.1403
Brugia malayi hypothetical protein 0.0012 0.0197 0.0274
Schistosoma mansoni cpg binding protein 0.0031 0.0648 0.0648
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.1529 0.4694
Loa Loa (eye worm) hypothetical protein 0.001 0.0143 0.0085
Toxoplasma gondii hypothetical protein 0.0133 0.3123 1
Trichomonas vaginalis chitinase, putative 0.0012 0.0197 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0143 0.0085
Mycobacterium ulcerans chitinase/cellulase 0.0071 0.163 1
Echinococcus multilocularis cpg binding protein 0.0031 0.0648 0.0578
Brugia malayi Hepatocellular carcinoma-associated antigen 59 family protein 0.0133 0.3123 1
Onchocerca volvulus Putative endochitinase 0.0094 0.2175 0.6817
Loa Loa (eye worm) hypothetical protein 0.0012 0.0197 0.0265
Onchocerca volvulus Putative chitinase 0.0012 0.0197 0.0182
Brugia malayi endochitinase 0.0094 0.2175 0.6847
Onchocerca volvulus Putative endochitinase 0.0012 0.0197 0.0182
Echinococcus multilocularis Glycoside hydrolase, chitinase domain containing protein 1 0.0012 0.0197 0.0124
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.1529 0.5
Loa Loa (eye worm) cuticular endochitinase 0.0084 0.193 0.6029
Plasmodium vivax hypothetical protein, conserved 0.0133 0.3123 1
Schistosoma mansoni cpg binding protein 0.0031 0.0648 0.0648
Loa Loa (eye worm) hypothetical protein 0.0133 0.3123 1
Echinococcus multilocularis dnaJ subfamily B 0.0417 1 1
Loa Loa (eye worm) chitinase I 0.0084 0.193 0.6029
Schistosoma mansoni cpg binding protein 0.0029 0.0608 0.0608
Onchocerca volvulus 0.0029 0.0608 0.1558
Loa Loa (eye worm) chitin binding Peritrophin-A domain-containing protein 0.001 0.0143 0.0085
Echinococcus granulosus Hepatocellular carcinoma associated antigen 59 0.0133 0.3123 0.3072
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.1529 0.4699
Brugia malayi Chitin binding Peritrophin-A domain containing protein 0.001 0.0143 0.0094
Loa Loa (eye worm) hypothetical protein 0.001 0.0143 0.0085
Schistosoma mansoni hypothetical protein 0.0417 1 1
Brugia malayi Chitin binding Peritrophin-A domain containing protein 0.001 0.0143 0.0094
Brugia malayi CXXC zinc finger family protein 0.0029 0.0608 0.1638
Loa Loa (eye worm) hypothetical protein 0.001 0.0143 0.0085
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.1529 0.5
Schistosoma mansoni chitinase 0.0012 0.0197 0.0197
Onchocerca volvulus 0.0133 0.3123 1
Loa Loa (eye worm) hypothetical protein 0.0133 0.3123 1
Loa Loa (eye worm) chitin binding Peritrophin-A domain-containing protein 0.001 0.0143 0.0085
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.1529 0.1465
Loa Loa (eye worm) hypothetical protein 0.0071 0.163 0.5033
Echinococcus granulosus Glycoside hydrolase chitinase domain containing protein 1 0.0012 0.0197 0.0124
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0074 0.0074
Echinococcus multilocularis Hepatocellular carcinoma associated antigen 59 0.0133 0.3123 0.3072
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0842 0.0773
Onchocerca volvulus Putative endochitinase 0.0084 0.193 0.5995
Echinococcus granulosus cpg binding protein 0.0031 0.0648 0.0578
Brugia malayi Chitin binding Peritrophin-A domain containing protein 0.001 0.0143 0.0094
Entamoeba histolytica chitinase, putative 0.0084 0.193 1
Brugia malayi Endochitinase 0.0094 0.2175 0.6847
Brugia malayi Endochitinase 0.0012 0.0197 0.0274
Brugia malayi Glycosyl hydrolases family 18 protein 0.0012 0.0197 0.0274
Brugia malayi hypothetical protein 0.0012 0.0197 0.0274
Onchocerca volvulus Putative endochitinase 0.0094 0.2175 0.6817
Onchocerca volvulus Putative endochitinase 0.0084 0.193 0.5995

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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