Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glycosyl hydrolase family 18 protein | 0.0012 | 0.0197 | 0.0265 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.3123 | 1 |
Brugia malayi | hypothetical protein | 0.0012 | 0.0197 | 0.0274 |
Echinococcus granulosus | Hepatocellular carcinoma associated antigen 59 | 0.0133 | 0.3123 | 0.3072 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0197 | 0.0265 |
Entamoeba histolytica | chitinase, putative | 0.0084 | 0.193 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0143 | 0.0085 |
Echinococcus multilocularis | Glycoside hydrolase, chitinase domain containing protein 1 | 0.0012 | 0.0197 | 0.0124 |
Schistosoma mansoni | chitinase | 0.0012 | 0.0197 | 0.0197 |
Trichomonas vaginalis | chitinase, putative | 0.0012 | 0.0197 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0143 | 0.0085 |
Brugia malayi | Chitin binding Peritrophin-A domain containing protein | 0.001 | 0.0143 | 0.0094 |
Schistosoma mansoni | hypothetical protein | 0.0417 | 1 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.0608 | 0.163 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0417 | 1 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0118 | 0.0044 |
Onchocerca volvulus | Putative endochitinase | 0.0094 | 0.2175 | 0.6817 |
Onchocerca volvulus | Putative chitinase | 0.0012 | 0.0197 | 0.0182 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0067 | 0.1529 | 0.4699 |
Echinococcus granulosus | Glycoside hydrolase chitinase domain containing protein 1 | 0.0012 | 0.0197 | 0.0124 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0197 | 0.0265 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0118 | 0.0044 |
Echinococcus multilocularis | cpg binding protein | 0.0031 | 0.0648 | 0.0578 |
Onchocerca volvulus | Putative endochitinase | 0.0012 | 0.0197 | 0.0182 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0143 | 0.0085 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0062 | 0.1403 | 0.1403 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0648 | 0.0648 |
Loa Loa (eye worm) | cuticular endochitinase | 0.0084 | 0.193 | 0.6029 |
Leishmania major | chitinase | 0.0084 | 0.193 | 1 |
Echinococcus multilocularis | Hepatocellular carcinoma associated antigen 59 | 0.0133 | 0.3123 | 0.3072 |
Echinococcus granulosus | cpg binding protein | 0.0031 | 0.0648 | 0.0578 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0067 | 0.1529 | 0.1529 |
Onchocerca volvulus | Putative endochitinase | 0.0084 | 0.193 | 0.5995 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0143 | 0.0085 |
Mycobacterium tuberculosis | Possible chitinase | 0.0071 | 0.163 | 0.5 |
Brugia malayi | Endochitinase | 0.0094 | 0.2175 | 0.6847 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0039 | 0.0842 | 0.0773 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0071 | 0.163 | 1 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0071 | 0.163 | 1 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0039 | 0.0842 | 0.0773 |
Schistosoma mansoni | hypothetical protein | 0.0133 | 0.3123 | 0.3123 |
Loa Loa (eye worm) | chitin binding Peritrophin-A domain-containing protein | 0.001 | 0.0143 | 0.0085 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.163 | 0.5033 |
Loa Loa (eye worm) | chitin binding Peritrophin-A domain-containing protein | 0.001 | 0.0143 | 0.0085 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0067 | 0.1529 | 0.1465 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0067 | 0.1529 | 0.5 |
Brugia malayi | endochitinase | 0.0084 | 0.193 | 0.6032 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0648 | 0.0648 |
Brugia malayi | Endochitinase | 0.0012 | 0.0197 | 0.0274 |
Onchocerca volvulus | Putative endochitinase | 0.0094 | 0.2175 | 0.6817 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0074 | 0.0074 |
Onchocerca volvulus | Putative endochitinase | 0.0094 | 0.2175 | 0.6817 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0143 | 0.0085 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0143 | 0.0085 |
Brugia malayi | Hepatocellular carcinoma-associated antigen 59 family protein | 0.0133 | 0.3123 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.3123 | 1 |
Brugia malayi | Glycosyl hydrolases family 18 protein | 0.0012 | 0.0197 | 0.0274 |
Onchocerca volvulus | 0.0133 | 0.3123 | 1 | |
Onchocerca volvulus | 0.0133 | 0.3123 | 1 | |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.0608 | 0.1638 |
Loa Loa (eye worm) | chitinase I | 0.0084 | 0.193 | 0.6029 |
Plasmodium vivax | hypothetical protein, conserved | 0.0133 | 0.3123 | 1 |
Brugia malayi | Chitin binding Peritrophin-A domain containing protein | 0.001 | 0.0143 | 0.0094 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0143 | 0.0085 |
Brugia malayi | hypothetical protein | 0.0012 | 0.0197 | 0.0274 |
Toxoplasma gondii | hypothetical protein | 0.0133 | 0.3123 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.0084 | 0.193 | 0.5995 |
Brugia malayi | Chitin binding Peritrophin-A domain containing protein | 0.001 | 0.0143 | 0.0094 |
Plasmodium falciparum | conserved protein, unknown function | 0.0133 | 0.3123 | 1 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0067 | 0.1529 | 0.7684 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0143 | 0.0085 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0067 | 0.1529 | 0.4694 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0067 | 0.1529 | 0.5 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0067 | 0.1529 | 0.1465 |
Onchocerca volvulus | 0.0029 | 0.0608 | 0.1558 | |
Brugia malayi | endochitinase | 0.0094 | 0.2175 | 0.6847 |
Brugia malayi | Glycosyl hydrolases family 18 protein | 0.0012 | 0.0197 | 0.0274 |
Loa Loa (eye worm) | microfilarial chitinase | 0.0082 | 0.1875 | 0.5848 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0608 | 0.0608 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0067 | 0.1529 | 0.5 |
Brugia malayi | Chitin binding Peritrophin-A domain containing protein | 0.001 | 0.0143 | 0.0094 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.