TDR Targets

Basic information

Technical information

TDR Targets ID: 738992
Name: N-[4-[4-(3-methylbutanoyl)piperazin-1-yl]phen yl]-2-phenylacetamide
MW: 379.495 | Formula: C23H29N3O2
H donors: 1 H acceptors: 2 LogP: 3.35 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CC(CC(=O)N1CCN(CC1)c1ccc(cc1)NC(=O)Cc1ccccc1)C
InChi: 1S/C23H29N3O2/c1-18(2)16-23(28)26-14-12-25(13-15-26)21-10-8-20(9-11-21)24-22(27)17-19-6-4-3-5-7-19/h3-11,18H,12-17H2,1-2H3,(H,24,27)
InChiKey: YHEDKYOYQKCBTN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[4-[4-(3-methylbutanoyl)piperazin-1-yl]phenyl]-2-phenyl-acetamide
N-[4-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]phenyl]-2-phenylacetamide
N-[4-(4-isovalerylpiperazin-1-yl)phenyl]-2-phenyl-acetamide
N-[4-[4-(3-methylbutanoyl)piperazin-1-yl]phenyl]-2-phenyl-ethanamide
ZINC06715944
STK236751

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0019	0.426	0.426
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.3933	0.3933
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0018	0.3933	0.6421
Echinococcus granulosus	G protein coupled receptor 139	0.0019	0.426	0.426
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	0.0034	1	1
Echinococcus multilocularis	orexin receptor type 2	0.0019	0.426	0.426
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0019	0.426	0.426
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.6125	0.6125
Schistosoma mansoni	neuropeptide receptor	0.0019	0.426	1
Loa Loa (eye worm)	hepatopoietin HPO2	0.0034	1	1
Trypanosoma cruzi	ERV/ALR sulfhydryl oxidase domain-containing protein	0.0034	1	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0019	0.426	0.426
Toxoplasma gondii	Erv1 / Alr family protein	0.0034	1	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Schistosoma mansoni	opsin-like receptor	0.0019	0.426	1
Brugia malayi	ORL1-like opioid receptor	0.0019	0.426	0.426
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0019	0.426	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.426	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.6125	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.6125	0.6125
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.6125	1
Echinococcus granulosus	FAD linked sulfhydryl oxidase ALR	0.0034	1	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Echinococcus multilocularis	FAD linked sulfhydryl oxidase ALR	0.0034	1	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.6125	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Echinococcus granulosus	allatostatin A receptor	0.0019	0.426	0.426
Echinococcus granulosus	fmrfamide receptor	0.0019	0.426	0.426
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.6125	0.6125
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0019	0.426	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.426	0.426
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0019	0.426	0.426
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Echinococcus granulosus	tm gpcr rhodopsin	0.0019	0.426	0.426
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Schistosoma mansoni	amine GPCR	0.0019	0.426	1
Schistosoma mansoni	amine GPCR	0.0019	0.426	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0019	0.426	0.426
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0019	0.426	0.426
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.426	1
Onchocerca volvulus		0.0019	0.426	0.6956
Brugia malayi	Dopamine receptor protein 1	0.0019	0.426	0.426
Loa Loa (eye worm)	hypothetical protein	0.0018	0.3933	0.3933
Echinococcus granulosus	sex peptide receptor	0.0019	0.426	0.426
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.426	0.426
Echinococcus granulosus	neuropeptide Y receptor	0.0019	0.426	0.426
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0019	0.426	0.426
Brugia malayi	Serotonin receptor	0.0019	0.426	0.426
Brugia malayi	putative neuropeptide receptor	0.0019	0.426	0.426
Onchocerca volvulus		0.0019	0.426	0.6956
Loa Loa (eye worm)	melatonin receptor type 1A	0.0019	0.426	0.426
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Loa Loa (eye worm)	neuropeptide F receptor	0.0019	0.426	0.426
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.426	0.426
Plasmodium vivax	FAD-linked sulfhydryl oxidase ERV1, putative	0.0034	1	1
Echinococcus granulosus	orexin receptor type 2	0.0019	0.426	0.426
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0019	0.426	0.426
Echinococcus multilocularis	allatostatin A receptor	0.0019	0.426	0.426
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0019	0.426	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.3579	0.5844
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.6125	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0019	0.426	0.426
Brugia malayi	Melatonin receptor type 1A	0.0019	0.426	0.426
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Echinococcus multilocularis	G protein coupled receptor 139	0.0019	0.426	0.426
Brugia malayi	GnHR receptor homolog	0.0019	0.426	0.426
Loa Loa (eye worm)	hypothetical protein	0.0024	0.6125	0.6125
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0019	0.426	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0019	0.426	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0019	0.426	0.426
Echinococcus multilocularis	neuropeptide receptor	0.0019	0.426	0.426
Schistosoma mansoni	hypothetical protein	0.0019	0.426	1
Brugia malayi	larval opioid receptor	0.0019	0.426	0.426
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.6125	1
Schistosoma mansoni	hypothetical protein	0.0019	0.426	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0019	0.426	0.426
Echinococcus granulosus	7TM GPCR rhodopsin	0.0019	0.426	0.426
Mycobacterium ulcerans	hypothetical protein	0.0024	0.6125	1
Echinococcus granulosus	neuropeptide receptor	0.0019	0.426	0.426
Brugia malayi	neuropeptide F receptor	0.0019	0.426	0.426
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.426	0.426
Echinococcus granulosus	neuropeptide receptor	0.0019	0.426	0.426
Echinococcus multilocularis	fmrfamide receptor	0.0019	0.426	0.426
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.6125	1
Schistosoma mansoni	myosin xvIII	0.0019	0.426	1
Echinococcus multilocularis	g protein coupled receptor	0.0019	0.426	0.426
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Echinococcus multilocularis	dro:myosuppressin receptor	0.0019	0.426	0.426
Echinococcus granulosus	hypothetical protein	0.0019	0.426	0.426
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0019	0.426	0.426
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0019	0.426	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.6125	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.3579	0.5844
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0019	0.426	0.426
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0019	0.426	0.426
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Schistosoma mansoni	hypothetical protein	0.0019	0.426	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Echinococcus granulosus	g-protein coupled receptor	0.0019	0.426	0.426
Echinococcus granulosus	serotonin receptor	0.0019	0.426	0.426
Onchocerca volvulus		0.0024	0.6125	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.426	0.426
Schistosoma mansoni	histamine h1 receptor	0.0019	0.426	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0019	0.426	0.426
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0019	0.426	0.426
Brugia malayi	hypothetical protein	0.0019	0.426	0.426
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.6125	0.6125
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	0.0034	1	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0019	0.426	0.426
Brugia malayi	hypothetical protein	0.0019	0.426	0.426
Brugia malayi	Dopamine receptor protein 2	0.0019	0.426	0.426
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0019	0.426	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Echinococcus granulosus	biogenic amine 5HT receptor	0.0019	0.426	0.426
Onchocerca volvulus		0.0019	0.426	0.6956
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0019	0.426	0.426
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.426	0.426
Echinococcus multilocularis	g protein coupled receptor	0.0019	0.426	0.426
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0019	0.426	0.426
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.6125	0.6125
Brugia malayi	follicle stimulating hormone receptor	0.0019	0.426	0.426
Echinococcus multilocularis	sex peptide receptor	0.0019	0.426	0.426
Loa Loa (eye worm)	hypothetical protein	0.0018	0.3933	0.3933
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0019	0.426	0.6956
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.3579	0.5844
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0019	0.426	0.426
Echinococcus multilocularis	serotonin receptor	0.0019	0.426	0.426
Brugia malayi	G-protein coupled receptor	0.0019	0.426	0.426
Schistosoma mansoni	biogenic amine receptor	0.0019	0.426	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0019	0.426	0.426
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0019	0.426	0.426
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Echinococcus granulosus	somatostatin receptor	0.0019	0.426	0.426
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0019	0.426	0.426
Echinococcus multilocularis	neuropeptides capa receptor	0.0019	0.426	0.426
Onchocerca volvulus		0.0019	0.426	0.6956
Schistosoma mansoni	hypothetical protein	0.0019	0.426	1
Brugia malayi	Dopamine receptor	0.0019	0.426	0.426
Schistosoma mansoni	neuropeptide receptor	0.0019	0.426	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0019	0.426	0.426
Brugia malayi	G-protein coupled receptor	0.0019	0.426	0.426
Trichomonas vaginalis	antibiotic synthetase, putative	0.0007	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.426	1
Echinococcus granulosus	g protein coupled receptor	0.0019	0.426	0.426
Onchocerca volvulus		0.0019	0.426	0.6956
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.426	0.426
Loa Loa (eye worm)	neuropeptide F receptor	0.0019	0.426	0.426
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Schistosoma mansoni	opsin-like receptor	0.0019	0.426	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.426	0.426
Schistosoma mansoni	biogenic amine receptor	0.0019	0.426	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Echinococcus multilocularis	neuropeptide Y receptor	0.0019	0.426	0.426
Brugia malayi	hypothetical protein	0.0019	0.426	0.426
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0019	0.426	0.426
Plasmodium falciparum	FAD-linked sulfhydryl oxidase ERV1, putative	0.0034	1	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0019	0.426	0.426
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.6125	1
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.6125	0.6125
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0019	0.426	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0019	0.426	0.426
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0019	0.426	0.426
Brugia malayi	hypothetical protein	0.0019	0.426	0.426
Brugia malayi	RE15519p	0.0019	0.426	0.426
Schistosoma mansoni	neuropeptide receptor	0.0019	0.426	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0019	0.426	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0019	0.426	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0019	0.426	0.426
Brugia malayi	AKH receptor	0.0019	0.426	0.426
Schistosoma mansoni	biogenic amine receptor	0.0019	0.426	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.6125	1
Schistosoma mansoni	opsin-like receptor	0.0019	0.426	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0019	0.426	0.6956
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Brugia malayi	sulfakinin receptor protein	0.0019	0.426	0.426
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.426	0.426
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0019	0.426	0.426
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.426	0.426
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0019	0.426	1
Echinococcus granulosus	g protein coupled receptor	0.0019	0.426	0.426
Echinococcus granulosus	neuropeptide s receptor	0.0019	0.426	0.426
Echinococcus granulosus	g protein coupled receptor	0.0019	0.426	0.426
Toxoplasma gondii	Erv1 / Alr family protein	0.0034	1	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0019	0.426	0.426
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.426	1
Brugia malayi	hypothetical protein	0.0019	0.426	0.426
Loa Loa (eye worm)	hypothetical protein	0.0024	0.6125	0.6125
Schistosoma mansoni	amine GPCR	0.0019	0.426	1
Echinococcus granulosus	neuropeptides capa receptor	0.0019	0.426	0.426
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.6125	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.3933	0.3933
Brugia malayi	putative neuropeptide receptor NPR1	0.0019	0.426	0.426
Loa Loa (eye worm)	hypothetical protein	0.0018	0.3933	0.3933
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Onchocerca volvulus		0.0019	0.426	0.6956
Brugia malayi	hypothetical protein	0.0019	0.426	0.426
Onchocerca volvulus		0.0019	0.426	0.6956
Loa Loa (eye worm)	G-protein coupled receptor	0.0019	0.426	0.426
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.426	0.426
Onchocerca volvulus		0.0019	0.426	0.6956
Echinococcus granulosus	tm gpcr rhodopsin	0.0019	0.426	0.426
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0019	0.426	0.426
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Echinococcus granulosus	dro:myosuppressin receptor	0.0019	0.426	0.426
Echinococcus multilocularis	fmrfamide receptor	0.0019	0.426	0.426
Onchocerca volvulus		0.0019	0.426	0.6956
Echinococcus multilocularis	neuropeptide Y receptor	0.0019	0.426	0.426
Brugia malayi	hypothetical protein	0.0019	0.426	0.426
Brugia malayi	neuropeptide F receptor	0.0019	0.426	0.426
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Onchocerca volvulus		0.0019	0.426	0.6956
Echinococcus multilocularis	g-protein coupled receptor	0.0019	0.426	0.426
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0019	0.426	0.426
Trichomonas vaginalis	antibiotic synthetase, putative	0.0007	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.426	1
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.6125	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Schistosoma mansoni	amine GPCR	0.0019	0.426	1
Echinococcus granulosus	neuropeptide receptor A26	0.0019	0.426	0.426
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Echinococcus multilocularis	serotonin receptor	0.0019	0.426	0.426
Brugia malayi	G protein-coupled receptor	0.0019	0.426	0.426
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.426	0.426
Echinococcus granulosus	neuropeptide Y receptor	0.0019	0.426	0.426
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Brugia malayi	Serotonin receptor	0.0019	0.426	0.426
Schistosoma mansoni	amine GPCR	0.0019	0.426	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0019	0.426	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0019	0.426	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.426	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0019	0.426	0.426
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.426	0.426
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0019	0.426	0.426
Brugia malayi	hypothetical protein	0.0019	0.426	0.426
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Echinococcus multilocularis	neuropeptide s receptor	0.0019	0.426	0.426
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Brugia malayi	hypothetical protein	0.0019	0.426	0.426
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0019	0.426	0.426
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.426	0.426
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0019	0.426	0.426
Schistosoma mansoni	adenoreceptor	0.0019	0.426	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.426	0.426
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0019	0.426	0.426
Schistosoma mansoni	neuropeptide F-like receptor	0.0019	0.426	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0019	0.426	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.3579	0.5844
Echinococcus multilocularis	neuropeptide receptor	0.0019	0.426	0.426
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.6125	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0019	0.426	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Onchocerca volvulus		0.0019	0.426	0.6956
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.426	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Onchocerca volvulus		0.0019	0.426	0.6956
Onchocerca volvulus		0.0019	0.426	0.6956
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.426	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0019	0.426	0.426
Loa Loa (eye worm)	hypothetical protein	0.0018	0.3933	0.3933
Onchocerca volvulus		0.0019	0.426	0.6956
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0019	0.426	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.426	1
Leishmania major	hypothetical protein, conserved	0.0034	1	1
Echinococcus multilocularis	somatostatin receptor	0.0019	0.426	0.426
Echinococcus multilocularis	g protein coupled receptor	0.0019	0.426	0.426
Echinococcus granulosus	tm gpcr rhodopsin	0.0019	0.426	0.426
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0019	0.426	0.426
Brugia malayi	hypothetical protein	0.0019	0.426	0.426
Schistosoma mansoni	neuropeptide receptor	0.0019	0.426	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0019	0.426	1
Loa Loa (eye worm)	TYRA-2 protein	0.0019	0.426	0.426
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0019	0.426	0.426
Loa Loa (eye worm)	hypothetical protein	0.0018	0.3933	0.3933
Onchocerca volvulus		0.0019	0.426	0.6956
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0019	0.426	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.3933	0.6421
Brugia malayi	G protein-coupled receptor F59B2.13	0.0019	0.426	0.426
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0019	0.426	1
Trypanosoma brucei	ERV/ALR sulfhydryl oxidase domain-containing protein	0.0034	1	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.426	0.426
Echinococcus granulosus	neuropeptides capa receptor	0.0019	0.426	0.426
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.6125	1
Onchocerca volvulus		0.0019	0.426	0.6956
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.6125	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.6125	0.6125
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.3933	0.5
Onchocerca volvulus		0.0019	0.426	0.6956
Echinococcus multilocularis	neuropeptide receptor A26	0.0019	0.426	0.426

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 738992