Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0292 | 1 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0 | 0.5 |
Onchocerca volvulus | 0.0229 | 0.7607 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.939 | 1 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0276 | 0.939 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0138 | 0.4155 | 0.3871 |
Trichomonas vaginalis | set domain proteins, putative | 0.0229 | 0.7607 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0201 | 0.655 | 0.6976 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0154 | 0.4748 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.005 | 0.0805 | 0.0358 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.939 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0047 | 0.0693 | 1 |
Brugia malayi | NNMT/PNMT/TEMT family protein | 0.0276 | 0.939 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0 | 0.5 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0138 | 0.4155 | 0.3871 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0201 | 0.655 | 0.6976 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0 | 0.5 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0292 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0154 | 0.4748 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0292 | 1 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.