Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0557 | 0.6697 | 1 |
Echinococcus multilocularis | tumor suppressor p53 binding protein 1 | 0.0322 | 0.2726 | 0.4071 |
Echinococcus granulosus | tumor suppressor p53 binding protein 1 | 0.0322 | 0.2726 | 0.4071 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0557 | 0.6697 | 1 |
Onchocerca volvulus | 0.0161 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0322 | 0.2726 | 0.2726 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.12 uM | Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5' -monophosphate (dcAMP) | ChEMBL. | 2842503 |
IC50 (functional) | = 0.13 uM | Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamine | ChEMBL. | 2842503 |
Inhibition (functional) | = 56 % | Percent inhibition of total acid secretion in pylorus-ligated rats at an id dose of 20 mg/kg | ChEMBL. | 2842503 |
Inhibition (binding) | = 64 % | Evaluated for the inhibition of H+/K+ ATPase enzyme from fundic mucosa of white rabbits at 100 microM | ChEMBL. | 2842503 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.