Detailed information for compound 74433

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 309.275 | Formula: C13H15N3O6
  • H donors: 3 H acceptors: 5 LogP: -0.81 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@@H]1O[C@@H](C[C@@H]1O)n1cc(c2onc(c2)C)c(=O)[nH]c1=O
  • InChi: 1S/C13H15N3O6/c1-6-2-9(22-15-6)7-4-16(13(20)14-12(7)19)11-3-8(18)10(5-17)21-11/h2,4,8,10-11,17-18H,3,5H2,1H3,(H,14,19,20)/t8-,10-,11-/m1/s1
  • InChiKey: GBLOVFDLOVVYPI-FBIMIBRVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax histone deacetylase 2, putative 0.0148 0.0783 0.4684
Plasmodium vivax histone deacetylase, putative 0.0148 0.0783 0.4684
Loa Loa (eye worm) histone deacetylase 7A 0.0148 0.0783 0.2047
Plasmodium falciparum phosphodiesterase delta, putative 0.0136 0.0684 0.0684
Schistosoma mansoni calcium-activated potassium channel 0.039 0.2727 0.2727
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0258 0.1671 1
Echinococcus multilocularis histone deacetylase 7 0.0148 0.0783 0.0783
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.03 0.2005 0.2005
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0684 0.0684
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.1293 1 1
Schistosoma mansoni histone deacetylase 4 5 0.0148 0.0783 0.0783
Echinococcus multilocularis Protein Red 0.0105 0.0438 0.0438
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Schistosoma mansoni voltage-gated potassium channel 0.0062 0.0091 0.0091
Brugia malayi Histone deacetylase family protein 0.0148 0.0783 0.2047
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Loa Loa (eye worm) histone deacetylase 0.0148 0.0783 0.2047
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0258 0.1671 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0424 0.1109
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0136 0.0684 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0241 0.1534 0.544
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0526 0.3822 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Schistosoma mansoni hypothetical protein 0.039 0.2727 0.2727
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0136 0.0684 0.0684
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0127 0.0615 0.0615
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0136 0.0684 0.179
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0136 0.0684 0.0684
Schistosoma mansoni histone deacetylase 4 5 0.0148 0.0783 0.0783
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0136 0.0684 1
Trypanosoma brucei histone deacetylase, putative 0.0148 0.0783 0.0996
Echinococcus granulosus histone deacetylase 6 0.0148 0.0783 0.0783
Brugia malayi Suppressor of mec and unc defects protein 0.0105 0.0438 0.1146
Trypanosoma cruzi ion transport protein, putative 0.033 0.2246 1
Echinococcus granulosus potassium voltage gated channel protein 0.0108 0.0455 0.0455
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0136 0.0684 0.179
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0136 0.0684 0.0684
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0108 0.0455 0.0455
Loa Loa (eye worm) hypothetical protein 0.0175 0.1002 0.2621
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0684 0.0684
Schistosoma mansoni calcium-activated potassium channel 0.0371 0.2574 0.2574
Loa Loa (eye worm) hypothetical protein 0.0136 0.0684 0.179
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0684 0.0684
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0136 0.0684 0.0684
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0136 0.0684 0.0684
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0108 0.0455 0.1191
Giardia lamblia Hypothetical protein 0.0136 0.0684 0.5
Loa Loa (eye worm) voltage-gated potassium channel 0.0103 0.0422 0.1103
Loa Loa (eye worm) hypothetical protein 0.0136 0.0684 0.179
Trypanosoma brucei histone deacetylase 4 0.0148 0.0783 0.0996
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0136 0.0684 1
Loa Loa (eye worm) hypothetical protein 0.03 0.2005 0.5244
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0136 0.0684 0.5
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0136 0.0684 0.0684
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0136 0.0684 1
Loa Loa (eye worm) hypothetical protein 0.0105 0.0438 0.1146
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0136 0.0684 0.0684
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0059 0.0064 0.0167
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0526 0.3822 0.3822
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0136 0.0684 1
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0051 0 0.5
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0258 0.1671 0.6316
Plasmodium falciparum histone deacetylase 2 0.0148 0.0783 0.0783
Echinococcus granulosus small conductance calcium activated potassium 0.039 0.2727 0.2727
Echinococcus granulosus histone deacetylase 6 0.0148 0.0783 0.0783
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0136 0.0684 0.0684
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1293 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0059 0.0064 0.0064
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0258 0.1671 0.6316
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0684 0.0684
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0684 0.0684
Echinococcus granulosus sodium channel protein 0.0241 0.1534 0.1534
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0136 0.0684 0.179
Echinococcus granulosus histone deacetylase 7 0.0148 0.0783 0.0783
Echinococcus multilocularis small conductance calcium activated potassium 0.039 0.2727 0.2727
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0258 0.1671 0.1671
Leishmania major histone deacetylase, putative 0.0148 0.0783 0.0629
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0136 0.0684 1
Trypanosoma cruzi histone deacetylase, putative 0.0148 0.0783 0.0629
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0136 0.0684 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0424 0.1109
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0059 0.0064 0.0167
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0136 0.0684 0.0684
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0684 0.0684
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0136 0.0684 1
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0136 0.0684 1
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0136 0.0684 0.0684
Plasmodium falciparum histone deacetylase, putative 0.0148 0.0783 0.0783
Loa Loa (eye worm) norepinephrine transporter 0.03 0.2005 0.5244
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.1293 1 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.016 0.0878 0.0878
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0136 0.0684 0.4096
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0136 0.0684 0.0684
Schistosoma mansoni red protein (ik factor) (cytokine ik) 0.0105 0.0438 0.0438
Schistosoma mansoni voltage-gated potassium channel 0.0108 0.0455 0.0455
Loa Loa (eye worm) hypothetical protein 0.039 0.2727 0.7135
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Trypanosoma cruzi histone deacetylase, putative 0.0148 0.0783 0.0629
Plasmodium vivax phosphodiesterase gamma, putative 0.0136 0.0684 0.4096
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0526 0.3822 0.3822
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.016 0.0878 0.0878
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.1293 1 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0136 0.0684 1
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0258 0.1671 0.6316
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0136 0.0684 0.0684
Loa Loa (eye worm) solute carrier family 6 member 4 0.03 0.2005 0.5244
Loa Loa (eye worm) hypothetical protein 0.0136 0.0684 0.179
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0136 0.0684 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0136 0.0684 0.0684
Echinococcus granulosus histone deacetylase 6 0.0148 0.0783 0.0783
Plasmodium falciparum phosphodiesterase gamma, putative 0.0136 0.0684 0.0684
Schistosoma mansoni voltage-gated potassium channel 0.0062 0.0091 0.0091
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0684 0.0684
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0136 0.0684 0.4096
Echinococcus granulosus histone deacetylase 0.0148 0.0783 0.0783
Trichomonas vaginalis conserved hypothetical protein 0.0136 0.0684 1
Echinococcus multilocularis serotonin transporter 0.03 0.2005 0.2005
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0059 0.0064 0.0064
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0136 0.0684 0.0684
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.03 0.2005 0.5244
Echinococcus granulosus Protein Red 0.0105 0.0438 0.0438
Echinococcus multilocularis histone deacetylase 6 0.0148 0.0783 0.0783
Loa Loa (eye worm) hypothetical protein 0.0136 0.0684 0.179
Loa Loa (eye worm) serotonin transporter b 0.03 0.2005 0.5244
Toxoplasma gondii RED family protein 0.0105 0.0438 0.0438
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0684 0.0684
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0136 0.0684 0.0684
Loa Loa (eye worm) hypothetical protein 0.0054 0.0024 0.0063
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0127 0.0615 0.0615
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0136 0.0684 0.0684
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0526 0.3822 0.3822
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0241 0.1534 0.1534
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0258 0.1671 0.1671
Loa Loa (eye worm) hypothetical protein 0.03 0.2005 0.5244
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0136 0.0684 0.0684
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0136 0.0684 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0136 0.0684 0.0684
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0136 0.0684 1
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0127 0.0615 0.0615
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0136 0.0684 0.0684
Leishmania major ion transport protein-like protein 0.033 0.2246 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Echinococcus multilocularis sodium channel protein 0.0241 0.1534 0.1534
Onchocerca volvulus 0.03 0.2005 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0136 0.0684 0.179
Echinococcus multilocularis histone deacetylase 6 0.0148 0.0783 0.0783
Echinococcus multilocularis histone deacetylase 6 0.0148 0.0783 0.0783
Echinococcus multilocularis histone deacetylase 0.0148 0.0783 0.0783
Loa Loa (eye worm) hypothetical protein 0.03 0.2005 0.5244
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0684 0.0684
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0136 0.0684 1
Brugia malayi Histone deacetylase family protein 0.0148 0.0783 0.2047
Echinococcus multilocularis potassium voltage gated channel protein 0.0108 0.0455 0.0455
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0684 0.0684
Treponema pallidum sodium- and chloride- dependent transporter 0.03 0.2005 0.5
Leishmania major histone deacetylase, putative 0.0148 0.0783 0.0629
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0684 0.0684
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0136 0.0684 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0136 0.0684 0.179
Schistosoma mansoni sodium/chloride dependent transporter 0.03 0.2005 0.2005
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0136 0.0684 1
Trichomonas vaginalis conserved hypothetical protein 0.0136 0.0684 1
Loa Loa (eye worm) hypothetical protein 0.0195 0.1163 0.3043
Mycobacterium ulcerans ion transport protein 0.0097 0.0367 0.5
Schistosoma mansoni histone deacetylase hda2 0.0148 0.0783 0.0783
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Trypanosoma cruzi ion transport protein, putative 0.033 0.2246 1
Loa Loa (eye worm) PDE1B protein 0.0526 0.3822 1
Trypanosoma cruzi histone deacetylase, putative 0.0148 0.0783 0.0629
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0684 0.0684
Trichomonas vaginalis conserved hypothetical protein 0.0136 0.0684 1
Trypanosoma brucei histone deacetylase 3 0.0148 0.0783 0.0996
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0136 0.0684 1
Schistosoma mansoni voltage-gated potassium channel 0.0108 0.0455 0.0455
Toxoplasma gondii histone deacetylase HDAC1 0.0148 0.0783 0.0783
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0136 0.0684 0.0684
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0104 0.0425 0.0425
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0127 0.0615 0.1609
Loa Loa (eye worm) hypothetical protein 0.0108 0.0455 0.1191
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0258 0.1671 0.1671
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0136 0.0684 0.0684
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0136 0.0684 1
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0136 0.0684 0.0684
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0258 0.1671 0.1671
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0136 0.0684 0.0684
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0136 0.0684 0.179
Echinococcus granulosus serotonin transporter 0.03 0.2005 0.2005
Giardia lamblia hypothetical protein 0.0136 0.0684 0.5

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) 0 ug ml-1 minimum inhibitory concentration required to reduce virus induced plaque formation in HEL cell culture of virus CMV (AD169) was measured; not determined ChEMBL. 2061920
MIC (functional) = 40 ug ml-1 Minimum inhibitory concentration required to reduce virus induced cytopathicity in embryonic skin muscle (E6SM) cell culture of virus HSV-1( F) was measured ChEMBL. 2061920
MIC (functional) = 52 ug ml-1 Minimum inhibitory concentration required to reduce virus induced plaque formation in HEL cell culture of virus VZS (YS) was measured ChEMBL. 2061920
MIC (functional) = 70 ug ml-1 Minimum inhibitory concentration required to reduce virus induced cytopathicity in embryonic skin muscle (E6SM) cell culture of virus HSV-1 (KOS) was measured ChEMBL. 2061920
MIC (functional) = 70 ug ml-1 Minimum inhibitory concentration required to reduce virus induced cytopathicity in embryonic skin muscle (E6SM) cell culture of virus HSV-1 (Mc Intyre) was measured ChEMBL. 2061920
MIC (functional) = 87 ug ml-1 Minimum inhibitory concentration required to reduce virus induced plaque formation in HEL cell culture of virus VZS (OKA) was measured ChEMBL. 2061920
MIC (functional) > 200 ug ml-1 Compound was evaluated in vitro for antiviral activity and cytotoxicity, and minimum inhibitory concentration required to reduce cell growth by 50% in HEL cell culture ChEMBL. 2061920
MIC (functional) = 250 ug ml-1 Minimum inhibitory concentration required to reduce virus induced plaque formation in HEL cell culture of virus CMV (Davis) was measured ChEMBL. 2061920
MIC (functional) > 400 ug ml-1 Minimum inhibitory concentration required to reduce virus induced cytopathicity in embryonic skin muscle (E6SM) cell culture of virus HSV-2 (G) was measured ChEMBL. 2061920
MIC (functional) > 400 ug ml-1 Minimum inhibitory concentration required to reduce virus induced cytopathicity in embryonic skin muscle (E6SM) cell culture of virus HSV-2 (196) was measured. ChEMBL. 2061920
MIC (functional) > 400 ug ml-1 Minimum inhibitory concentration required to reduce virus induced cytopathicity in embryonic skin muscle (E6SM) cell culture of virus HSV-2 (Lyons) was measured. ChEMBL. 2061920
MIC (functional) > 400 ug ml-1 Minimum inhibitory concentration required to reduce virus induced cytopathicity in embryonic skin muscle (E6SM) cell culture of virus TK- HSV-1 (B2006) was measured ChEMBL. 2061920
MIC (functional) > 400 ug ml-1 Minimum inhibitory concentration required to reduce virus induced cytopathicity in embryonic skin muscle (E6SM) cell culture of virus TK- HSV-1 (VMW1837) was measured ChEMBL. 2061920
MIC (functional) > 400 ug ml-1 Minimum concentration required to reduce virus induced plaque formation in HEL cell culture of virus TK- VZV (YS-R) was measured ChEMBL. 2061920
MIC (functional) > 400 ug ml-1 Minimum inhibitory concentration required to reduce virus induced plaque formation in HEL cell culture of virus TK- VZV (07-1) was measured ChEMBL. 2061920
MIC (functional) > 400 ug ml-1 Minimum inhibitory concentration required to reduce virus induced cytopathicity in embryonic skin muscle (E6SM) cell culture of virus VSV was measured ChEMBL. 2061920
MIC (functional) > 400 ug ml-1 Minimum inhibitory concentration required to reduce virus induced cytopathicity in embryonic skin muscle (E6SM) cell culture of virus VV was measured ChEMBL. 2061920
MIC (functional) > 400 ug ml-1 minimum inhibitory concentration required to to cause a microscopically detectable change in normal cell morphology ChEMBL. 2061920

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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