Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | 0.0061 | 0.0126 | 0.5 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0089 | 0.1977 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.2872 | 1 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0089 | 0.1977 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1774 | 0.3809 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.2745 | 0.9289 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0132 | 0.4722 | 0.3584 |
Schistosoma mansoni | ryanodine receptor related | 0.0106 | 0.3051 | 0.1552 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0076 | 0.1098 | 1 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0076 | 0.1098 | 1 |
Brugia malayi | cation channel family protein | 0.0162 | 0.6675 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 291 % | Anticancer activity against P388 leukemia | ChEMBL. | 8510107 |
Activity (functional) | = 310 % | Anticancer activity against implanted lewis lung carcinoma in mice | ChEMBL. | 8510107 |
Cytotoxicity (functional) | = 11.3 uM | Tested against human KB cells in culture (3+ at 10 micro g/mL) | ChEMBL. | 8510107 |
Solubility (ADMET) | > 10 mg ml-1 | Water solubility of the compound was determined | ChEMBL. | 8510107 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.