Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0049 | 0.0823 | 0.1659 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0115 | 0.2798 | 0.6106 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0032 | 0.0331 | 0.0331 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0115 | 0.2798 | 0.588 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.0115 | 0.2798 | 0.588 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0313 | 0.0313 |
Loa Loa (eye worm) | intermediate filament protein | 0.0032 | 0.0331 | 0.0331 |
Onchocerca volvulus | 0.0032 | 0.0331 | 0.5 | |
Trypanosoma brucei | Voltage-dependent calcium channel subunit, putative | 0.007 | 0.1455 | 0.5 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0115 | 0.2798 | 0.6106 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0115 | 0.2798 | 0.588 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0115 | 0.2798 | 0.588 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0331 | 0.0331 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0115 | 0.2798 | 0.588 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0115 | 0.2798 | 0.6106 |
Trypanosoma cruzi | Voltage-dependent calcium channel subunit, putative | 0.007 | 0.1455 | 0.5 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.0115 | 0.2798 | 0.588 |
Loa Loa (eye worm) | voltage-dependent calcium channel beta 2a subunit | 0.0355 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0032 | 0.0331 | 0.055 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0024 | 0.0087 | 1 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0115 | 0.2798 | 0.588 |
Schistosoma mansoni | high voltage-activated calcium channel beta subunit 2 | 0.0172 | 0.4527 | 1 |
Brugia malayi | Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog | 0.0115 | 0.2798 | 0.2552 |
Echinococcus granulosus | high voltage activated calcium channel beta | 0.0172 | 0.4527 | 1 |
Loa Loa (eye worm) | voltage-dependent calcium channel | 0.0024 | 0.0087 | 0.0087 |
Echinococcus multilocularis | high voltage activated calcium channel beta | 0.0172 | 0.4527 | 1 |
Echinococcus multilocularis | sodium channel protein | 0.0049 | 0.0823 | 0.1173 |
Onchocerca volvulus | 0.0032 | 0.0331 | 0.5 | |
Schistosoma mansoni | voltage-gated cation channel | 0.0115 | 0.2798 | 0.588 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0115 | 0.2798 | 0.588 |
Echinococcus granulosus | intermediate filament protein | 0.0032 | 0.0331 | 0.055 |
Loa Loa (eye worm) | calcium channel | 0.0115 | 0.2798 | 0.2798 |
Echinococcus granulosus | lamin dm0 | 0.0032 | 0.0331 | 0.055 |
Schistosoma mansoni | hypothetical protein | 0.0062 | 0.1214 | 0.2105 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0115 | 0.2798 | 0.6106 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0087 | 0.0087 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.2798 | 0.2798 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
C10 (functional) | > 440 uM | Concentration required to reduce plating efficiency to 10 percent of controls, under hypoxic conditions in mouse SCCVII tumor cells. | ChEMBL. | 12502371 |
C10 (functional) | = 440 uM | Concentration required to reduce plating efficiency to 10 percent of controls, under aerobic conditions in mouse SCCVII tumor cells. | ChEMBL. | 12502371 |
HCR (functional) | < 1 | Intraexperimental difference between the hypoxic and aerobic cytotoxicity | ChEMBL. | 12502371 |
RHT (functional) | < 0.023 | Intraexperimental ratio of hypoxic TPZ C10 to hypoxic BTO C10 in mouse SCCVII tumor cells. | ChEMBL. | 12502371 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.