Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | plasminogen activator, urokinase | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Homo sapiens | plasminogen | Starlite/ChEMBL | References |
Homo sapiens | protease, serine, 1 (trypsin 1) | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | Mastin | plasminogen activator, urokinase | 414 aa | 340 aa | 24.4 % |
Brugia malayi | Trypsin family protein | protease, serine, 1 (trypsin 1) | 247 aa | 287 aa | 21.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hypothetical protein, conserved | 0.0083 | 0.0221 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0615 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0128 | 0.0615 | 1 |
Onchocerca volvulus | 0.0106 | 0.0423 | 0.1468 | |
Schistosoma mansoni | carbonic anhydrase-related | 0.0065 | 0.0065 | 0.1051 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1203 | 1 | 0.5 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0083 | 0.0221 | 0.5 |
Onchocerca volvulus | Putative sulfate transporter | 0.024 | 0.1593 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0065 | 0.0065 | 0.1051 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.0058 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1203 | 1 | 0.5 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0083 | 0.0221 | 0.2848 |
Brugia malayi | Trypsin family protein | 0.0128 | 0.0615 | 1 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0336 | 0.2425 | 0.0669 |
Leishmania major | carbonic anhydrase-like protein | 0.0065 | 0.0065 | 0.2919 |
Onchocerca volvulus | 0.024 | 0.1593 | 1 | |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0065 | 0.0065 | 0.1051 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0065 | 0.0065 | 0.1051 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0083 | 0.0221 | 1 |
Onchocerca volvulus | 0.0128 | 0.0615 | 0.287 | |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.1145 | 0.9493 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0083 | 0.0221 | 0.3599 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0615 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0128 | 0.0615 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0083 | 0.0221 | 0.2848 |
Brugia malayi | Kringle domain containing protein | 0.0083 | 0.0221 | 0.2848 |
Leishmania major | hypothetical protein, conserved | 0.0083 | 0.0221 | 1 |
Mycobacterium leprae | Probable transmembrane transport protein | 0.0278 | 0.1918 | 1 |
Toxoplasma gondii | kringle domain-containing protein | 0.0083 | 0.0221 | 1 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0083 | 0.0221 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0083 | 0.0221 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0065 | 0.0065 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0221 | 0.2848 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0065 | 0.0065 | 0.1051 |
Schistosoma mansoni | carbonic anhydrase | 0.0065 | 0.0065 | 0.1051 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.0065 | 0.1051 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
2x aPPT (functional) | = 0.75 uM | In vitro anticoagulant effect to double the activated partial thromboplastin time in human plasma | ChEMBL. | 11459634 |
Ki (binding) | = 0.0007 uM | Inhibitory activity against Coagulation factor X in human plasma | ChEMBL. | 11459634 |
Ki (binding) | = 0.0007 uM | Inhibitory activity against Coagulation factor X in human plasma | ChEMBL. | 11459634 |
Ki (binding) | = 0.04 uM | Inhibitory activity against thrombin(fIIa) in human plasma | ChEMBL. | 11459634 |
Ki (binding) | = 0.04 uM | Inhibitory activity against thrombin(fIIa) in human plasma | ChEMBL. | 11459634 |
Ki (binding) | = 0.27 uM | Inhibitory activity against urokinase-type plasminogen activator (microPa) in human plasma | ChEMBL. | 11459634 |
Ki (binding) | = 0.27 uM | Inhibitory activity against urokinase-type plasminogen activator (microPa) in human plasma | ChEMBL. | 11459634 |
Ki (binding) | = 0.61 uM | Inhibitory activity against trypsin in human plasma | ChEMBL. | 11459634 |
Ki (binding) | = 0.61 uM | Inhibitory activity against trypsin in human plasma | ChEMBL. | 11459634 |
Ki (binding) | = 1.5 uM | Inhibitory activity against plasmin in human plasma | ChEMBL. | 11459634 |
Ki (binding) | = 1.5 uM | Inhibitory activity against plasmin in human plasma | ChEMBL. | 11459634 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.