Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | purinergic receptor P2Y, G-protein coupled, 12 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0111 | 0.1188 | 1 | |
Schistosoma mansoni | amine oxidase | 0.0111 | 0.1188 | 0.1188 |
Loa Loa (eye worm) | calcium channel | 0.0161 | 0.1797 | 0.6865 |
Brugia malayi | hypothetical protein | 0.0111 | 0.1188 | 0.454 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0161 | 0.1797 | 0.1797 |
Loa Loa (eye worm) | voltage-dependent calcium channel | 0.0056 | 0.053 | 0.2025 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1188 | 0.454 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0161 | 0.1797 | 0.2073 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0111 | 0.1188 | 1 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0161 | 0.1797 | 0.2073 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1188 | 0.454 |
Brugia malayi | SWIRM domain containing protein | 0.0111 | 0.1188 | 0.454 |
Echinococcus multilocularis | 0.0111 | 0.1188 | 0.1188 | |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0111 | 0.1188 | 0.1371 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0161 | 0.1797 | 0.1797 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0111 | 0.1188 | 0.1371 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0229 | 0.2617 | 1 |
Trypanosoma brucei | Voltage-dependent calcium channel subunit, putative | 0.0056 | 0.053 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1188 | 0.454 |
Schistosoma mansoni | amine oxidase | 0.0111 | 0.1188 | 0.1188 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0448 | 0.1713 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0111 | 0.1188 | 0.1188 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.0161 | 0.1797 | 0.1797 |
Brugia malayi | follicle stimulating hormone receptor | 0.0229 | 0.2617 | 1 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0056 | 0.053 | 0.0612 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0842 | 1 | 0.5 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0842 | 1 | 1 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.0731 | 0.8665 | 1 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0161 | 0.1797 | 0.1797 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0056 | 0.053 | 0.1104 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1188 | 0.454 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0111 | 0.1188 | 0.454 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.0161 | 0.1797 | 0.1797 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0111 | 0.1188 | 0.1188 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0161 | 0.1797 | 0.1797 |
Schistosoma mansoni | voltage-gated cation channel | 0.0161 | 0.1797 | 0.1797 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0161 | 0.1797 | 0.1797 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.1797 | 0.6865 |
Plasmodium vivax | hypothetical protein, conserved | 0.0111 | 0.1188 | 0.5 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0111 | 0.1188 | 0.5 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0111 | 0.1188 | 0.5 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0161 | 0.1797 | 0.1797 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0111 | 0.1188 | 0.5 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0111 | 0.1188 | 0.5 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.0731 | 0.8665 | 1 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0842 | 1 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0111 | 0.1188 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0111 | 0.1188 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0111 | 0.1188 | 0.5 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0161 | 0.1797 | 0.2073 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0111 | 0.1188 | 1 |
Brugia malayi | Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog | 0.0161 | 0.1797 | 0.6865 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0161 | 0.1797 | 0.2073 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1188 | 0.454 |
Leishmania major | UDP-galactopyranose mutase | 0.0111 | 0.1188 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.053 | 0.2025 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0448 | 0.1713 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1188 | 0.454 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0111 | 0.1188 | 0.5 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0842 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.2 uM | Binding affinity against Purinergic receptor P2Y12 using [3H]-2-methylthio-ADP as radioligand | ChEMBL. | 12729666 |
IC50 (binding) | = 2.2 uM | Binding affinity against Purinergic receptor P2Y12 using [3H]-2-methylthio-ADP as radioligand | ChEMBL. | 12729666 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.