Detailed information for compound 757114

Basic information

Technical information
  • TDR Targets ID: 757114
  • Name: 7-(difluoromethyl)-N-[(2-fluorophenyl)methyl] -5-(4-methylphenyl)pyrazolo[1,5-a]pyrimidine- 3-carboxamide
  • MW: 410.392 | Formula: C22H17F3N4O
  • H donors: 1 H acceptors: 3 LogP: 3.88 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)c1cc(C(F)F)n2c(n1)c(cn2)C(=O)NCc1ccccc1F
  • InChi: 1S/C22H17F3N4O/c1-13-6-8-14(9-7-13)18-10-19(20(24)25)29-21(28-18)16(12-27-29)22(30)26-11-15-4-2-3-5-17(15)23/h2-10,12,20H,11H2,1H3,(H,26,30)
  • InChiKey: HHNQTBUTYPDJIP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-(difluoromethyl)-N-[(2-fluorophenyl)methyl]-5-(4-methylphenyl)-3-pyrazolo[1,5-a]pyrimidinecarboxamide
  • 7-(difluoromethyl)-N-(2-fluorobenzyl)-5-(4-methylphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans peptide deformylase 0.0462 0.9442 1
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0462 0.9442 1
Toxoplasma gondii hypothetical protein 0.0462 0.9442 1
Treponema pallidum polypeptide deformylase (def) 0.0462 0.9442 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.056 0.5354
Schistosoma mansoni hypothetical protein 0.0068 0.1045 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0913 0.0967
Brugia malayi Latrophilin receptor protein 2 0.0031 0.027 0.0309
Trypanosoma brucei Polypeptide deformylase 1 0.0176 0.3357 1
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0462 0.9442 1
Trypanosoma cruzi Peptide deformylase 2, putative 0.0176 0.3357 1
Schistosoma mansoni hypothetical protein 0.0031 0.027 0.2587
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.1713 0.196
Loa Loa (eye worm) hypothetical protein 0.0062 0.0913 0.1045
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.027 0.0309
Trichomonas vaginalis set domain proteins, putative 0.0489 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.1713 0.196
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0462 0.9442 0.5
Plasmodium falciparum peptide deformylase 0.0462 0.9442 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0913 0.1355
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.027 0.0401
Echinococcus multilocularis GPCR, family 2 0.0031 0.027 0.0401
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.1045 0.1196
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0913 0.8735
Chlamydia trachomatis peptide deformylase 0.0462 0.9442 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.056 0.064
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.027 0.0401
Schistosoma mansoni hypothetical protein 0.0031 0.027 0.2587
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0176 0.3357 1
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0647 0.6192
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.056 0.083
Leishmania major polypeptide deformylase-like protein, putative 0.0176 0.3357 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.056 0.064
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.027 0.0401
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.056 0.5354
Plasmodium vivax SET domain protein, putative 0.0062 0.0913 0.0967
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.027 0.0309
Echinococcus multilocularis tumor protein p63 0.0335 0.6739 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0913 0.8735
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.056 0.083
Brugia malayi Pre-SET motif family protein 0.0062 0.0913 0.1045
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0068 0.1045 0.1196
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0913 0.1355
Brugia malayi Pre-SET motif family protein 0.0429 0.8738 1
Trypanosoma brucei Peptide deformylase 2 0.0176 0.3357 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.027 0.0309
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0913 0.1355
Onchocerca volvulus 0.0062 0.0913 0.0284
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0913 0.8735
Echinococcus granulosus tumor protein p63 0.0335 0.6739 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0913 0.8735
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0 0.5
Plasmodium vivax peptide deformylase, putative 0.0462 0.9442 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.056 0.083
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.027 0.0401
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0865 0.1283
Schistosoma mansoni hypothetical protein 0.0031 0.027 0.2587
Echinococcus granulosus GPCR family 2 0.0031 0.027 0.0401
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0429 0.8738 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.1713 0.196
Loa Loa (eye worm) hypothetical protein 0.0049 0.0647 0.0741
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.056 0.5354
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.056 0.083
Trypanosoma cruzi Peptide deformylase 2, putative 0.0176 0.3357 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.1713 0.196
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0176 0.3357 1
Schistosoma mansoni hypothetical protein 0.0031 0.027 0.2587

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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