Detailed information for compound 757122

Basic information

Technical information
  • TDR Targets ID: 757122
  • Name: 7-(difluoromethyl)-N-(3-fluoro-4-methylphenyl )-5-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin e-3-carboxamide
  • MW: 426.391 | Formula: C22H17F3N4O2
  • H donors: 1 H acceptors: 3 LogP: 3.91 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1cc(C(F)F)n2c(n1)c(cn2)C(=O)Nc1ccc(c(c1)F)C
  • InChi: 1S/C22H17F3N4O2/c1-12-3-6-14(9-17(12)23)27-22(30)16-11-26-29-19(20(24)25)10-18(28-21(16)29)13-4-7-15(31-2)8-5-13/h3-11,20H,1-2H3,(H,27,30)
  • InChiKey: PZYGQYIZULTWAT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-(difluoromethyl)-N-(3-fluoro-4-methyl-phenyl)-5-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
  • 7-(difluoromethyl)-N-(3-fluoro-4-methylphenyl)-5-(4-methoxyphenyl)-3-pyrazolo[1,5-a]pyrimidinecarboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0669 0.0669
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0669 0.0955
Echinococcus multilocularis microtubule associated protein 2 0.0675 1 1
Onchocerca volvulus 0.0502 0.7356 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0669 0.0669
Loa Loa (eye worm) pigment dispersing factor receptor c 0.015 0.1999 0.3111
Echinococcus granulosus GPCR family 2 0.0048 0.0431 0.0431
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0669 0.0669
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0431 0.0431
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0183 0.2491 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0431 0.0671
Schistosoma mansoni hypothetical protein 0.0103 0.1273 0.1273
Trypanosoma brucei Peptide deformylase 2 0.0183 0.2491 1
Schistosoma mansoni hypothetical protein 0.0048 0.0431 0.0431
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0669 0.0669
Plasmodium falciparum peptide deformylase 0.0479 0.7007 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.015 0.1999 0.3111
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0431 0.0671
Chlamydia trachomatis peptide deformylase 0.0479 0.7007 0.5
Loa Loa (eye worm) hypothetical protein 0.0048 0.0431 0.0671
Plasmodium vivax SET domain protein, putative 0.0063 0.0669 0.0955
Trypanosoma brucei Polypeptide deformylase 1 0.0183 0.2491 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0431 0.0431
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0479 0.7007 0.5
Treponema pallidum polypeptide deformylase (def) 0.0479 0.7007 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0441 0.6427 1
Trypanosoma cruzi Peptide deformylase 2, putative 0.0183 0.2491 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0 0.5
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0634 0.0634
Loa Loa (eye worm) hypothetical protein 0.0103 0.1273 0.1981
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0479 0.7007 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0431 0.0671
Schistosoma mansoni microtubule-associated protein tau 0.0675 1 1
Toxoplasma gondii hypothetical protein 0.0479 0.7007 1
Trichomonas vaginalis set domain proteins, putative 0.0502 0.7356 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0669 0.0669
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0479 0.7007 1
Schistosoma mansoni hypothetical protein 0.0048 0.0431 0.0431
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0669 0.0669
Schistosoma mansoni hypothetical protein 0.0048 0.0431 0.0431
Schistosoma mansoni hypothetical protein 0.0048 0.0431 0.0431
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0183 0.2491 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0669 0.0669
Loa Loa (eye worm) hypothetical protein 0.015 0.1999 0.3111
Plasmodium vivax peptide deformylase, putative 0.0479 0.7007 1
Brugia malayi Pre-SET motif family protein 0.0441 0.6427 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.015 0.1999 0.3111
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0431 0.0431
Mycobacterium ulcerans peptide deformylase 0.0479 0.7007 1
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.1273 0.1981
Echinococcus multilocularis GPCR, family 2 0.0048 0.0431 0.0431
Leishmania major polypeptide deformylase-like protein, putative 0.0183 0.2491 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0 0.5
Trypanosoma cruzi Peptide deformylase 2, putative 0.0183 0.2491 1
Brugia malayi Pre-SET motif family protein 0.0063 0.0669 0.1042
Loa Loa (eye worm) hypothetical protein 0.0063 0.0669 0.1042
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0431 0.0431

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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