Detailed information for compound 757194

Basic information

Technical information
  • TDR Targets ID: 757194
  • Name: 7-(difluoromethyl)-N-(1-methoxypropan-2-yl)-5 -(4-methylphenyl)pyrazolo[1,5-a]pyrimidine-3- carboxamide
  • MW: 374.385 | Formula: C19H20F2N4O2
  • H donors: 1 H acceptors: 3 LogP: 2.57 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCC(NC(=O)c1cnn2c1nc(cc2C(F)F)c1ccc(cc1)C)C
  • InChi: 1S/C19H20F2N4O2/c1-11-4-6-13(7-5-11)15-8-16(17(20)21)25-18(24-15)14(9-22-25)19(26)23-12(2)10-27-3/h4-9,12,17H,10H2,1-3H3,(H,23,26)
  • InChiKey: VJVAPTVOCCXQMO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 7-(difluoromethyl)-N-(2-methoxy-1-methyl-ethyl)-5-(4-methylphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
  • 7-(difluoromethyl)-N-(2-methoxy-1-methylethyl)-5-(4-methylphenyl)-3-pyrazolo[1,5-a]pyrimidinecarboxamide
  • ST5029428
  • BAS 09530663

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis GPCR, family 2 0.0047 0.0431 0.0431
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0669 0.0955
Chlamydia trachomatis peptide deformylase 0.0474 0.7002 0.5
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0474 0.7002 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0 0.5
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0431 0.0431
Schistosoma mansoni microtubule-associated protein tau 0.0669 1 1
Leishmania major polypeptide deformylase-like protein, putative 0.0181 0.249 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.1999 0.3112
Plasmodium vivax SET domain protein, putative 0.0063 0.0669 0.0955
Brugia malayi Calcitonin receptor-like protein seb-1 0.0149 0.1999 0.3112
Brugia malayi Pre-SET motif family protein 0.0437 0.6423 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0431 0.0431
Treponema pallidum polypeptide deformylase (def) 0.0474 0.7002 1
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.1273 0.1982
Schistosoma mansoni hypothetical protein 0.0047 0.0431 0.0431
Echinococcus granulosus GPCR family 2 0.0047 0.0431 0.0431
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0149 0.1999 0.3112
Onchocerca volvulus 0.0497 0.7351 1
Trichomonas vaginalis set domain proteins, putative 0.0497 0.7351 1
Trypanosoma cruzi Peptide deformylase 2, putative 0.0181 0.249 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0669 0.0669
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0474 0.7002 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0431 0.0431
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0431 0.0671
Schistosoma mansoni hypothetical protein 0.0047 0.0431 0.0431
Brugia malayi Pre-SET motif family protein 0.0063 0.0669 0.1041
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0669 0.0669
Trypanosoma brucei Polypeptide deformylase 1 0.0181 0.249 1
Trypanosoma brucei Peptide deformylase 2 0.0181 0.249 1
Echinococcus multilocularis microtubule associated protein 2 0.0669 1 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0633 0.0633
Schistosoma mansoni hypothetical protein 0.0047 0.0431 0.0431
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0669 0.0669
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0669 0.0669
Trypanosoma cruzi Peptide deformylase 2, putative 0.0181 0.249 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0669 0.0669
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0431 0.0671
Plasmodium vivax peptide deformylase, putative 0.0474 0.7002 1
Schistosoma mansoni hypothetical protein 0.0047 0.0431 0.0431
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0431 0.0431
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0669 0.0669
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0181 0.249 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0431 0.0671
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0437 0.6423 1
Plasmodium falciparum peptide deformylase 0.0474 0.7002 1
Toxoplasma gondii hypothetical protein 0.0474 0.7002 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0669 0.1041
Loa Loa (eye worm) hypothetical protein 0.0047 0.0431 0.0671
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0181 0.249 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0669 0.0669
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0149 0.1999 0.3112
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0474 0.7002 0.5
Schistosoma mansoni hypothetical protein 0.0102 0.1273 0.1273
Loa Loa (eye worm) hypothetical protein 0.0102 0.1273 0.1982
Mycobacterium ulcerans peptide deformylase 0.0474 0.7002 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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