Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | phospholipase A1, putative | 0.0324 | 0.5102 | 0.5 |
Trypanosoma cruzi | phospholipase A1, putative | 0.0324 | 0.5102 | 1 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.0492 | 1 | 1 |
Trypanosoma cruzi | phospholipase A1, putative | 0.0324 | 0.5102 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0492 | 1 | 1 |
Trypanosoma brucei | phospholipase A1, putative | 0.0324 | 0.5102 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.05 uM | Inhibitory concentration of vinblastine against the MDR resistant cell line HCT116/VM46 in the presence of 1 mM of the compound | ChEMBL. | 12729663 |
IC50 (functional) | = 0.05 uM | Inhibitory concentration of vinblastine against the MDR resistant cell line HCT116/VM46 in the presence of 1 mM of the compound | ChEMBL. | 12729663 |
IC50 (functional) | = 0.4 uM | Inhibitory concentration of doxorubicin against the MDR resistant cell line HCT116/VM46 in the presence of 1 mM of the compound | ChEMBL. | 12729663 |
IC50 (functional) | = 0.4 uM | Inhibitory concentration of doxorubicin against the MDR resistant cell line HCT116/VM46 in the presence of 1 mM of the compound | ChEMBL. | 12729663 |
IC50 (functional) | = 25 uM | Inhibitory concentration against human carcinoma HCT116 cell line | ChEMBL. | 12729663 |
IC50 (functional) | = 25 uM | Inhibitory concentration against MDR human carcinoma HCT116/VM46 cell line | ChEMBL. | 12729663 |
IC50 (functional) | = 25 uM | Inhibitory concentration against human carcinoma HCT116 cell line | ChEMBL. | 12729663 |
IC50 (functional) | = 25 uM | Inhibitory concentration against MDR human carcinoma HCT116/VM46 cell line | ChEMBL. | 12729663 |
Reversion (functional) | = 8 % | Percent reversion of the compound was determined in HCT116 cell line (IC50(-)/MDR IC50(+) X 100 | ChEMBL. | 12729663 |
Reversion (functional) | = 8 % | Percent reversion of the compound was determined in HCT116 cell line (IC50(-)/MDR IC50(+) X 100 | ChEMBL. | 12729663 |
Reversion (functional) | = 23 % | Percent reversion of the compound was determined in HCT116 cell line (IC50(-)/MDR IC50(+) X 100 | ChEMBL. | 12729663 |
Reversion (functional) | = 23 % | Percent reversion of the compound was determined in HCT116 cell line (IC50(-)/MDR IC50(+) X 100 | ChEMBL. | 12729663 |
Sensitivity (functional) | = 2 | Gain in sensitivity is measured as MDR IC50 (without added drug) / MDR IC50 (with added drug) in MDR HCT116/VM46 cell line | ChEMBL. | 12729663 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 12729663 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.