Detailed information for compound 760669

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 430.54 | Formula: C23H34N4O4
  • H donors: 0 H acceptors: 4 LogP: 1.23 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)CCCC(=O)N1CCCC(C1)CCC(=O)N1CCN(CC1)c1ccccn1
  • InChi: 1S/C23H34N4O4/c1-31-23(30)9-4-8-21(28)27-13-5-6-19(18-27)10-11-22(29)26-16-14-25(15-17-26)20-7-2-3-12-24-20/h2-3,7,12,19H,4-6,8-11,13-18H2,1H3
  • InChiKey: OFWNIQMRJBSQEI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tumor protein p63 0.0346 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0145 0.143
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.3198 0.3198
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0896 0.2319
Schistosoma mansoni lamin 0.0054 0.1013 0.2624
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0134 0.5
Onchocerca volvulus 0.0054 0.1013 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0134 0.5
Entamoeba histolytica hypothetical protein 0.0074 0.1611 0.5
Echinococcus granulosus lamin dm0 0.0054 0.1013 0.1013
Schistosoma mansoni lamin 0.0054 0.1013 0.2624
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0145 0.0145
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0134 0.5
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.1611 0.4171
Entamoeba histolytica hypothetical protein 0.0074 0.1611 0.5
Echinococcus multilocularis lamin dm0 0.0054 0.1013 0.1013
Schistosoma mansoni hypothetical protein 0.0035 0.0415 0.1075
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0415 0.2578
Schistosoma mansoni hypothetical protein 0.0125 0.3198 0.8278
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.1013 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0134 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0916 0.5683
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0916 0.9035
Echinococcus granulosus lamin 0.0054 0.1013 0.1013
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.1013 0.629
Onchocerca volvulus 0.0054 0.1013 1
Schistosoma mansoni thyroid hormone receptor 0.0147 0.3863 1
Schistosoma mansoni thyroid hormone receptor 0.0147 0.3863 1
Entamoeba histolytica hypothetical protein 0.0074 0.1611 0.5
Schistosoma mansoni hypothetical protein 0.0074 0.1611 0.4171
Echinococcus granulosus intermediate filament protein 0.0054 0.1013 0.1013
Loa Loa (eye worm) hypothetical protein 0.0025 0.0114 0.1127
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0916 0.5683
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0134 0.5
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.3198 0.3198
Brugia malayi intermediate filament protein 0.0054 0.1013 0.629
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.1611 0.1611
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0134 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.0415 0.4099
Entamoeba histolytica hypothetical protein 0.0074 0.1611 0.5
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0145 0.0145
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0234 0.1453
Loa Loa (eye worm) hypothetical protein 0.0051 0.0896 0.8839
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0134 0.5
Loa Loa (eye worm) hypothetical protein 0.0025 0.0114 0.1127
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0234 0.2309
Echinococcus multilocularis musashi 0.0054 0.1013 0.1013
Echinococcus multilocularis lamin 0.0054 0.1013 0.1013
Loa Loa (eye worm) intermediate filament protein 0.0054 0.1013 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.1013 1
Brugia malayi hypothetical protein 0.0026 0.0134 0.0832
Leishmania major hypothetical protein, conserved 0.0026 0.0134 0.5
Loa Loa (eye worm) hypothetical protein 0.0053 0.0983 0.9697
Onchocerca volvulus 0.0051 0.0896 0.8839
Schistosoma mansoni intermediate filament proteins 0.0054 0.1013 0.2624
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.1611 0.1611
Brugia malayi hypothetical protein 0.0074 0.1611 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0134 0.1323
Echinococcus multilocularis thyroid hormone receptor alpha 0.0147 0.3863 0.3863
Loa Loa (eye worm) hypothetical protein 0.0051 0.0916 0.9035

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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