Detailed information for compound 762199

Basic information

Technical information
  • TDR Targets ID: 762199
  • Name: 4-methyl-N-[4-(5-methyl-1,3-benzoxazol-2-yl)p henyl]benzamide
  • MW: 342.391 | Formula: C22H18N2O2
  • H donors: 1 H acceptors: 2 LogP: 4.99 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)C(=O)Nc1ccc(cc1)c1oc2c(n1)cc(cc2)C
  • InChi: 1S/C22H18N2O2/c1-14-3-6-16(7-4-14)21(25)23-18-10-8-17(9-11-18)22-24-19-13-15(2)5-12-20(19)26-22/h3-13H,1-2H3,(H,23,25)
  • InChiKey: HDNYFXYPIITMDE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • EU-0077920
  • STK173672
  • Oprea1_843308
  • ZINC04184235

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Chlamydia trachomatis peptide deformylase 0.0479 0.6948 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.1102 0.1733
Schistosoma mansoni hypothetical protein 0.0048 0.0243 0.0243
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0087 0.0137
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0183 0.2343 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0486 0.0581
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0479 0.6948 1
Schistosoma mansoni hypothetical protein 0.0048 0.0243 0.0243
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0479 0.6948 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0087 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.015 0.1842 0.2897
Trypanosoma brucei Polypeptide deformylase 1 0.0183 0.2343 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0243 0.0382
Brugia malayi Pre-SET motif family protein 0.0063 0.0486 0.0764
Loa Loa (eye worm) pigment dispersing factor receptor c 0.015 0.1842 0.2897
Schistosoma mansoni hypothetical protein 0.0103 0.1102 0.1102
Loa Loa (eye worm) hypothetical protein 0.0103 0.1102 0.1733
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0243 0.0243
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0087 0.0087
Schistosoma mansoni hypothetical protein 0.0048 0.0243 0.0243
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0243 0.0243
Trypanosoma cruzi Peptide deformylase 2, putative 0.0183 0.2343 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0486 0.0486
Schistosoma mansoni microtubule-associated protein tau 0.0675 1 1
Schistosoma mansoni hypothetical protein 0.0048 0.0243 0.0243
Schistosoma mansoni ap endonuclease 0.0038 0.0087 0.0087
Trypanosoma brucei Peptide deformylase 2 0.0183 0.2343 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0486 0.0486
Echinococcus multilocularis GPCR, family 2 0.0048 0.0243 0.0243
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0479 0.6948 0.5
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0449 0.0449
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0441 0.6357 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0243 0.0382
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0243 0.0243
Onchocerca volvulus 0.0502 0.7304 1
Loa Loa (eye worm) hypothetical protein 0.015 0.1842 0.2897
Trichomonas vaginalis set domain proteins, putative 0.0502 0.7304 1
Plasmodium vivax peptide deformylase, putative 0.0479 0.6948 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0087 0.5
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0243 0.0382
Plasmodium vivax SET domain protein, putative 0.0063 0.0486 0.0581
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0087 0.0087
Echinococcus multilocularis microtubule associated protein 2 0.0675 1 1
Schistosoma mansoni ap endonuclease 0.0038 0.0087 0.0087
Leishmania major polypeptide deformylase-like protein, putative 0.0183 0.2343 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0486 0.0486
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0087 0.0137
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.015 0.1842 0.2897
Loa Loa (eye worm) hypothetical protein 0.0063 0.0486 0.0764
Treponema pallidum polypeptide deformylase (def) 0.0479 0.6948 1
Brugia malayi Pre-SET motif family protein 0.0441 0.6357 1
Echinococcus granulosus GPCR family 2 0.0048 0.0243 0.0243
Toxoplasma gondii hypothetical protein 0.0479 0.6948 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0243 0.0243
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0486 0.0486
Plasmodium falciparum peptide deformylase 0.0479 0.6948 1
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0183 0.2343 1
Mycobacterium ulcerans peptide deformylase 0.0479 0.6948 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0486 0.0486
Trypanosoma cruzi Peptide deformylase 2, putative 0.0183 0.2343 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0486 0.0486
Onchocerca volvulus 0.0063 0.0486 0.0665
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0048 0.0243 0.0382

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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