Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0017 | 0.0578 | 0.5 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0017 | 0.0578 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.2636 | 0.2636 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0017 | 0.0578 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0048 | 0.2744 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0017 | 0.0578 | 0.5 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0111 | 0.699 | 0.8837 |
Treponema pallidum | NADH oxidase | 0.0017 | 0.0578 | 0.5 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0017 | 0.0578 | 0.2108 |
Brugia malayi | MH2 domain containing protein | 0.0122 | 0.7798 | 1 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0017 | 0.0578 | 0.2108 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.2636 | 0.9606 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0123 | 0.7834 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0048 | 0.2744 | 0.3519 |
Leishmania major | trypanothione reductase | 0.0048 | 0.2744 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0048 | 0.2744 | 0.2985 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0048 | 0.2744 | 0.3519 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0111 | 0.699 | 0.8837 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0111 | 0.699 | 0.8837 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0123 | 0.7834 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0048 | 0.2744 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0123 | 0.7834 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.2636 | 0.2636 |
Mycobacterium tuberculosis | Probable reductase | 0.0111 | 0.699 | 0.8837 |
Trypanosoma brucei | trypanothione reductase | 0.0048 | 0.2744 | 1 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0017 | 0.0578 | 0.0578 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0012 | 0.0274 | 0.0351 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0017 | 0.0578 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0048 | 0.2744 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.2636 | 0.9606 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0048 | 0.2744 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0048 | 0.2744 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0017 | 0.0578 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0048 | 0.2744 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.2636 | 0.338 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0111 | 0.699 | 0.8837 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0017 | 0.0578 | 0.5 |
Loa Loa (eye worm) | glutathione reductase | 0.0048 | 0.2744 | 0.3519 |
Plasmodium vivax | glutathione reductase, putative | 0.0048 | 0.2744 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.2636 | 0.9606 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0017 | 0.0578 | 0.5 |
Brugia malayi | glutathione reductase | 0.0048 | 0.2744 | 0.3519 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0123 | 0.7834 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0122 | 0.7798 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.2636 | 0.9606 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.2636 | 0.2636 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0012 | 0.0274 | 0.0351 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0048 | 0.2744 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0122 | 0.7798 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0017 | 0.0578 | 0.0742 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.2636 | 0.338 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0111 | 0.699 | 0.8837 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0017 | 0.0578 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.