Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Nicastrin | 0.1394 | 0.0662 | 0.0509 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.6946 | 0.3817 | 1 |
Echinococcus multilocularis | presenilin enhancer 2 | 0.2685 | 0.1395 | 0.1255 |
Trypanosoma brucei | Presenilin enhancer-2 subunit of gamma secretase, putative | 0.0808 | 0.0328 | 0.0459 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 1.7825 | 1 | 1 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 1.7825 | 1 | 1 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 1.7825 | 1 | 1 |
Echinococcus multilocularis | Nicastrin | 0.1394 | 0.0662 | 0.0509 |
Brugia malayi | hypothetical protein | 0.1394 | 0.0662 | 0.0233 |
Loa Loa (eye worm) | hypothetical protein | 0.1394 | 0.0662 | 0.0343 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.6946 | 0.3817 | 1 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.2861 | 0.1495 | 0.365 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.2861 | 0.1495 | 1 |
Brugia malayi | gamma-secretase subunit pen-2 | 0.2685 | 0.1395 | 0.1 |
Brugia malayi | Amyloid A4 extracellular domain containing protein | 0.3838 | 0.2051 | 0.1686 |
Loa Loa (eye worm) | presenilin spe-4 | 0.1002 | 0.0439 | 0.0112 |
Leishmania major | presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative | 0.2861 | 0.1495 | 1 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.2861 | 0.1495 | 1 |
Schistosoma mansoni | alzheimer's disease beta-amyloid related | 0.14 | 0.0665 | 0.0003 |
Echinococcus granulosus | presenilin | 0.2861 | 0.1495 | 0.1356 |
Loa Loa (eye worm) | gamma-secretase subunit pen-2 | 0.2685 | 0.1395 | 0.1101 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.2861 | 0.1495 | 0.365 |
Trypanosoma brucei | presenilin-like aspartic peptidase, putative | 0.2861 | 0.1495 | 0.365 |
Echinococcus multilocularis | Nicastrin | 0.1394 | 0.0662 | 0.0509 |
Brugia malayi | hypothetical protein | 0.1394 | 0.0662 | 0.0233 |
Toxoplasma gondii | hypothetical protein | 0.1002 | 0.0439 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3025 | 0.1588 | 0.1301 |
Brugia malayi | Presenilin family protein | 0.2861 | 0.1495 | 0.1105 |
Entamoeba histolytica | presenilin 1 peptidase, putative | 0.2861 | 0.1495 | 1 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 1.7825 | 1 | 1 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.2861 | 0.1495 | 1 |
Schistosoma mansoni | subfamily A22A unassigned peptidase (A22 family) | 0.2861 | 0.1495 | 0.0892 |
Echinococcus multilocularis | presenilin | 0.2861 | 0.1495 | 0.1356 |
Trypanosoma brucei | Aph-1 protein, putative | 0.6946 | 0.3817 | 1 |
Echinococcus granulosus | presenilin enhancer 2 | 0.2685 | 0.1395 | 0.1255 |
Loa Loa (eye worm) | hypothetical protein | 0.1625 | 0.0793 | 0.0478 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.