Detailed information for compound 765309

Basic information

Technical information
  • TDR Targets ID: 765309
  • Name: 5-[(4-methoxyphenoxy)methyl]-3-(4-methylpheny l)-1,2,4-oxadiazole
  • MW: 296.321 | Formula: C17H16N2O3
  • H donors: 0 H acceptors: 2 LogP: 3.64 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)OCc1onc(n1)c1ccc(cc1)C
  • InChi: 1S/C17H16N2O3/c1-12-3-5-13(6-4-12)17-18-16(22-19-17)11-21-15-9-7-14(20-2)8-10-15/h3-10H,11H2,1-2H3
  • InChiKey: MQQFFUYBRMQDKJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-(4-Methoxy-phenoxymethyl)-3-p-tolyl-[1,2,4]oxadiazole
  • BAS 03848568
  • Oprea1_381557
  • ZINC00432968
  • STK144089

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis carbonic anhydrase 0.0028 0.027 0.0587
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0404 0.0877
Plasmodium vivax lysine--tRNA ligase, putative 0.0025 0.0201 0.0201
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0035 0.0404 0.0404
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.004 0.051 0.2171
Loa Loa (eye worm) hypothetical protein 0.0028 0.027 0.0918
Echinococcus multilocularis calcium dependent protein kinase 0.0033 0.0357 0.0776
Schistosoma mansoni carbonic anhydrase-related 0.0028 0.027 0.1153
Trichomonas vaginalis CAMK family protein kinase 0.0035 0.0404 0.1927
Echinococcus granulosus carbonic anhydrase II 0.0125 0.2347 0.5097
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0035 0.0404 0.1369
Loa Loa (eye worm) hypothetical protein 0.0035 0.0404 0.1369
Plasmodium falciparum calcium-dependent protein kinase 3 0.0035 0.0404 0.0404
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0034 0.0388 0.1318
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.004 0.051 0.2171
Loa Loa (eye worm) hypothetical protein 0.0028 0.027 0.0918
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.0413 0.176
Echinococcus multilocularis carbonic anhydrase 0.0028 0.027 0.0587
Echinococcus multilocularis General substrate transporter 0.0097 0.1752 0.3805
Onchocerca volvulus Matrilysin homolog 0.0063 0.1018 0.3805
Echinococcus granulosus calcium dependent protein kinase 0.0033 0.0357 0.0776
Toxoplasma gondii lysine-tRNA ligase 0.0025 0.0201 0.0308
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0016 0 0.5
Brugia malayi Hemopexin family protein 0.009 0.1586 0.5383
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0028 0.027 0.0918
Trypanosoma cruzi hexose transporter 0.0035 0.0413 0.176
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0077 0.1314 0.446
Schistosoma mansoni glucose transport protein 0.0113 0.2094 0.8924
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0034 0.0388 0.1655
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0035 0.0404 0.0617
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0035 0.0404 0.0404
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0113 0.2094 0.4549
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0034 0.0388 0.1318
Trypanosoma cruzi hexose transporter, putative 0.0019 0.007 0.03
Trichomonas vaginalis glucose transporter, putative 0.0035 0.0413 0.1973
Echinococcus granulosus carbonic anhydrase 0.0028 0.027 0.0587
Entamoeba histolytica protein kinase, putative 0.0035 0.0404 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0201 0.1531
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0404 0.0877
Brugia malayi lysyl-tRNA synthetase 0.0025 0.0201 0.0683
Plasmodium falciparum calcium-dependent protein kinase 1 0.0035 0.0404 0.0404
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0034 0.0388 0.9253
Leishmania major glucose transporter, lmgt2 0.0035 0.0413 0.176
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0413 0.1973
Plasmodium falciparum calcium-dependent protein kinase 2 0.0035 0.0404 0.0404
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0413 0.1973
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0025 0.0201 0.0686
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0404 0.0877
Trypanosoma brucei glucose transporter 2A 0.0035 0.0413 0.176
Echinococcus granulosus carbonic anhydrase 0.0028 0.027 0.0587
Schistosoma mansoni carbonic anhydrase 0.0028 0.027 0.1153
Giardia lamblia Lysyl-tRNA synthetase 0.0025 0.0201 0.5182
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0034 0.0388 0.1655
Schistosoma mansoni carbonic anhydrase-related 0.0028 0.027 0.1153
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0125 0.2347 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0404 0.0877
Plasmodium falciparum hexose transporter 0.0113 0.2094 0.2094
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0413 0.1973
Trypanosoma brucei glucose transporter, putative 0.0035 0.0413 0.176
Brugia malayi Matrixin family protein 0.0063 0.1018 0.3454
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0125 0.2347 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0201 0.1531
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0077 0.1314 1
Plasmodium falciparum carbonic anhydrase 0.0028 0.027 0.027
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0035 0.0404 0.172
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.0413 0.176
Brugia malayi Matrixin family protein 0.0063 0.1018 0.3454
Plasmodium falciparum lysine--tRNA ligase 0.0025 0.0201 0.0201
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0063 0.1018 0.4337
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0034 0.0388 0.0844
Plasmodium falciparum mitogen-activated protein kinase 2 0.0183 0.3595 0.3595
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0035 0.0404 0.0617
Echinococcus multilocularis carbonic anhydrase 0.0028 0.027 0.0587
Toxoplasma gondii hypothetical protein 0.0028 0.027 0.0413
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0025 0.0201 0.0858
Loa Loa (eye worm) hypothetical protein 0.0077 0.1314 0.446
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0404 0.0877
Schistosoma mansoni protein kinase 0.0035 0.0404 0.172
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0404 0.172
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0035 0.0404 0.0404
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0113 0.2094 0.4549
Onchocerca volvulus Matrilysin homolog 0.014 0.2675 1
Brugia malayi Cam kinase protein 1 0.0035 0.0404 0.1369
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0113 0.2094 0.4549
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0125 0.2347 0.7963
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0201 0.0961
Loa Loa (eye worm) hypothetical protein 0.0063 0.1018 0.3454
Loa Loa (eye worm) sugar transporter 0.0113 0.2094 0.7107
Chlamydia trachomatis lysine--tRNA ligase 0.0025 0.0201 0.5
Plasmodium vivax CDK-related protein kinase 6, putative 0.048 1 1
Trypanosoma brucei glucose transporter, putative 0.0035 0.0413 0.176
Loa Loa (eye worm) hypothetical protein 0.0063 0.1018 0.3454
Loa Loa (eye worm) matrixin family protein 0.014 0.2675 0.9077
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.004 0.051 0.2171
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0413 0.1973
Plasmodium vivax hexose transporter 0.0113 0.2094 0.2094
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0034 0.0388 0.2252
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.2094 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0201 0.0858
Echinococcus granulosus carbonic anhydrase 0.0028 0.027 0.0587
Plasmodium falciparum proline--tRNA ligase 0.004 0.051 0.051
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0125 0.2347 0.7963
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0035 0.0404 0.0877
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0028 0.027 0.0918
Trichomonas vaginalis glucose transporter, putative 0.0035 0.0413 0.1973
Plasmodium falciparum calcium-dependent protein kinase 4 0.0035 0.0404 0.0404
Brugia malayi Sugar transporter family protein 0.0113 0.2094 0.7107
Loa Loa (eye worm) hypothetical protein 0.0063 0.1018 0.3454
Trypanosoma brucei glucose transporter, putative 0.0035 0.0413 0.176
Plasmodium falciparum calcium-dependent protein kinase 5 0.0035 0.0404 0.0404
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0035 0.0404 0.0617
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0113 0.2094 0.4549
Trypanosoma brucei glucose transporter, putative 0.0035 0.0413 0.176
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0413 0.176
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0035 0.0404 0.1369
Onchocerca volvulus 0.0063 0.1018 0.3805
Schistosoma mansoni protein kinase 0.0035 0.0404 0.172
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0035 0.0404 0.1369
Schistosoma mansoni hypothetical protein 0.0113 0.2094 0.8924
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0025 0.0201 0.0858
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0413 0.1973
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0183 0.3595 0.5495
Echinococcus multilocularis carbonic anhydrase II 0.0125 0.2347 0.5097
Echinococcus granulosus General substrate transporter 0.0097 0.1752 0.3805
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0413 0.176
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0032 0.0338 0.1439
Leishmania major carbonic anhydrase-like protein 0.0125 0.2347 1
Loa Loa (eye worm) carbonic anhydrase 3 0.0125 0.2347 0.7963
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.023 0.4604 1
Mycobacterium ulcerans hydrolase 0.0077 0.1314 1
Entamoeba histolytica protein kinase, putative 0.0035 0.0404 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0113 0.2094 0.3201
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0028 0.027 0.0918
Mycobacterium leprae PROBABLE HYDROLASE 0.0077 0.1314 1
Leishmania major protein kinase, putative 0.0035 0.0404 0.172
Leishmania major glucose transporter, lmgt3 0.0035 0.0413 0.176
Loa Loa (eye worm) hypothetical protein 0.0034 0.0388 0.1318
Plasmodium vivax calcium-dependent protein kinase, putative 0.0035 0.0404 0.0404
Echinococcus granulosus lysyl tRNA synthetase 0.0025 0.0201 0.0437
Trypanosoma brucei glucose transporter, putative 0.0035 0.0413 0.176
Loa Loa (eye worm) hypothetical protein 0.0028 0.027 0.0918
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0125 0.2347 1
Leishmania major lysyl-tRNA synthetase, putative 0.0025 0.0201 0.0858
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0034 0.0388 0.1855
Trypanosoma brucei glucose transporter 1E 0.0035 0.0413 0.176
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0413 0.176
Plasmodium vivax proline--tRNA ligase, putative 0.004 0.051 0.051
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0021 0.0119 0.0908
Loa Loa (eye worm) matrix metalloproteinase 0.0063 0.1018 0.3454
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0404 0.0877
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0028 0.027 0.0918
Toxoplasma gondii protein kinase, putative 0.032 0.6542 1
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.004 0.051 0.0779
Trypanosoma brucei glucose transporter, putative 0.0035 0.0413 0.176
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0125 0.2347 0.7963
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0404 0.0877
Trypanosoma brucei glucose transporter, putative 0.0035 0.0413 0.176
Schistosoma mansoni carbonic anhydrase-related 0.0028 0.027 0.1153
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0113 0.2094 0.4549
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0028 0.027 0.0918
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0034 0.0388 0.0844
Leishmania major glucose transporter/membrane transporter D2, putative 0.0035 0.0413 0.176
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0022 0.0134 0.0641
Loa Loa (eye worm) hypothetical protein 0.0028 0.0251 0.0853
Schistosoma mansoni hypothetical protein 0.0028 0.027 0.1153
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0113 0.2094 0.4549
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0113 0.2094 0.4549
Loa Loa (eye worm) hypothetical protein 0.0025 0.0201 0.0683
Brugia malayi Matrixin family protein 0.0153 0.2947 1
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.004 0.051 0.2171
Loa Loa (eye worm) matrixin family protein 0.0153 0.2947 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0125 0.2347 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0113 0.2094 0.4549
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0021 0.0119 0.0908
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.004 0.051 0.2171
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.023 0.4604 1
Schistosoma mansoni glucose transport protein 0.0113 0.2094 0.8924
Trypanosoma brucei glucose transporter, putative 0.0035 0.0413 0.176
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0183 0.3595 0.3595
Plasmodium falciparum protein kinase 7 0.032 0.6542 0.6542
Schistosoma mansoni hypothetical protein 0.009 0.1586 0.676
Echinococcus multilocularis lysyl tRNA synthetase 0.0025 0.0201 0.0437
Brugia malayi Matrixin family protein 0.0063 0.1018 0.3454
Onchocerca volvulus 0.009 0.1586 0.5931
Giardia lamblia Prolyl-tRNA synthetase 0.0034 0.0388 1
Trypanosoma brucei carbonic anhydrase-like protein 0.0125 0.2347 1
Brugia malayi Matrixin family protein 0.0063 0.1018 0.3454
Onchocerca volvulus Matrix metalloproteinase homolog 0.014 0.2675 1
Leishmania major glucose transporter, lmgt1 0.0035 0.0413 0.176
Schistosoma mansoni protein kinase 0.0035 0.0404 0.172
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0201 0.0858
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0028 0.027 0.0918
Loa Loa (eye worm) hypothetical protein 0.0034 0.0388 0.1318
Schistosoma mansoni glucose transport protein 0.0113 0.2094 0.8924
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.0413 0.176

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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