Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | neuropeptide s receptor | 0.0472 | 1 | 1 |
Onchocerca volvulus | 0.0081 | 0.062 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.062 | 0.2602 |
Echinococcus multilocularis | geminin | 0.0165 | 0.2632 | 0.2632 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.062 | 0.2602 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0472 | 1 | 1 |
Toxoplasma gondii | transporter, major facilitator family protein | 0.0081 | 0.062 | 0.1451 |
Schistosoma mansoni | organic anion transporter | 0.0081 | 0.062 | 0.2357 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.0081 | 0.062 | 0.2602 |
Onchocerca volvulus | 0.0081 | 0.062 | 1 | |
Echinococcus multilocularis | Solute carrier organic anion transporter family | 0.0081 | 0.062 | 0.062 |
Brugia malayi | hypothetical protein | 0.0081 | 0.062 | 0.2602 |
Loa Loa (eye worm) | STAT protein | 0.0155 | 0.2384 | 1 |
Onchocerca volvulus | Putative organic anion transporter | 0.0081 | 0.062 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.062 | 0.2602 |
Loa Loa (eye worm) | sodium-independent organic anion transporter | 0.0081 | 0.062 | 0.2602 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.062 | 0.2602 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.0081 | 0.062 | 0.2602 |
Onchocerca volvulus | 0.0081 | 0.062 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.2632 | 1 |
Echinococcus granulosus | geminin | 0.0165 | 0.2632 | 0.2632 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0472 | 1 | 1 |
Toxoplasma gondii | 1,3-beta-glucan synthase component protein | 0.0233 | 0.4274 | 1 |
Onchocerca volvulus | Putative organic anion transporter | 0.0081 | 0.062 | 1 |
Onchocerca volvulus | 0.0081 | 0.062 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.062 | 0.2602 |
Onchocerca volvulus | 0.0081 | 0.062 | 1 | |
Onchocerca volvulus | Putative organic anion transporter | 0.0081 | 0.062 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.062 | 0.2602 |
Echinococcus multilocularis | organic anion transporting polypeptide 30B | 0.0081 | 0.062 | 0.062 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.2632 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.062 | 0.2602 |
Brugia malayi | hypothetical protein | 0.0081 | 0.062 | 0.2602 |
Brugia malayi | STAT protein, DNA binding domain containing protein | 0.0155 | 0.2384 | 1 |
Brugia malayi | prostaglandin transporter | 0.0081 | 0.062 | 0.2602 |
Trypanosoma cruzi | MFS transporter, putative | 0.0081 | 0.062 | 0.5 |
Schistosoma mansoni | organic anion transporter | 0.0081 | 0.062 | 0.2357 |
Echinococcus granulosus | Solute carrier organic anion transporter family | 0.0081 | 0.062 | 0.062 |
Echinococcus granulosus | organic anion transporting polypeptide 30B | 0.0081 | 0.062 | 0.062 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.0081 | 0.062 | 0.2602 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Delta SBP (functional) | = -28 mmHg | Evaluated for blood pressure lowering activity in spontaneously hypertensive rats (maximum change of systolic blood pressure (SBP)) at a dose of 1.25 mg/kg | ChEMBL. | 2842504 |
Time (functional) | = 0.5 hr | Time to reach peak plasma concentration in spontaneously hypertensive rats after oral administration of 1.25 mg/kg of the compound | ChEMBL. | 2842504 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.