Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | hedgehog | 0.0185 | 1 | 1 |
Brugia malayi | Hint module family protein | 0.005 | 0.1918 | 1 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.015 | 0.7874 | 0.5 |
Onchocerca volvulus | Putative nachr subunit | 0.0018 | 0 | 0.5 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.015 | 0.7874 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 51B1 Cyp51B1 | 0.015 | 0.7874 | 0.5 |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Brugia malayi | Hint module family protein | 0.005 | 0.1918 | 1 |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1918 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1918 | 1 |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0135 | 0.6986 | 1 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.015 | 0.7874 | 0.5 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.015 | 0.7874 | 0.5 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.015 | 0.7874 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.