Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-C motif) receptor 3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0175 | 0.4991 | 0.5057 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0324 | 0.9806 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0123 | 0.3319 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0123 | 0.3319 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0175 | 0.4991 | 0.5057 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1294 | 0.1319 |
Loa Loa (eye worm) | AUR protein kinase | 0.0123 | 0.3319 | 0.3385 |
Schistosoma mansoni | tyrosine kinase | 0.0171 | 0.4883 | 0.485 |
Schistosoma mansoni | ryanodine receptor related | 0.033 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0123 | 0.3319 | 1 |
Echinococcus multilocularis | insulin receptor | 0.0105 | 0.2725 | 0.2732 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0175 | 0.4991 | 0.5057 |
Trypanosoma brucei | aurora B kinase | 0.0123 | 0.3319 | 1 |
Schistosoma mansoni | ryanodine receptor 1 skeletal muscle | 0.0038 | 0.058 | 0.0519 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.1977 | 0.1925 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0101 | 0.2607 | 0.2559 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0123 | 0.3319 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0175 | 0.4991 | 0.4959 |
Brugia malayi | Protein kinase domain containing protein | 0.0105 | 0.2725 | 0.2725 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0123 | 0.3319 | 1 |
Loa Loa (eye worm) | ryanodine receptor | 0.0123 | 0.3329 | 0.3395 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0648 | 0.0661 |
Brugia malayi | cation channel family protein | 0.0141 | 0.3904 | 0.3904 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0105 | 0.2725 | 0.2732 |
Schistosoma mansoni | tyrosine kinase | 0.0171 | 0.4883 | 0.485 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0267 | 0.7974 | 0.8119 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0123 | 0.3319 | 1 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0208 | 0.6077 | 0.6172 |
Brugia malayi | MIR domain containing protein | 0.0022 | 0.0064 | 0.0064 |
Brugia malayi | serine/threonine kinase 12 | 0.0123 | 0.3319 | 0.3319 |
Echinococcus granulosus | insulin receptor | 0.0105 | 0.2725 | 0.2732 |
Trichomonas vaginalis | AGC family protein kinase | 0.0123 | 0.3319 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0105 | 0.2725 | 0.2678 |
Loa Loa (eye worm) | MIR domain-containing protein | 0.0022 | 0.0064 | 0.0065 |
Giardia lamblia | Aurora kinase | 0.0123 | 0.3319 | 0.5 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.004 | 0.0648 | 0.0588 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0123 | 0.3319 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0324 | 0.9806 | 1 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0324 | 0.9806 | 0.9806 |
Entamoeba histolytica | protein kinase , putative | 0.0123 | 0.3319 | 1 |
Echinococcus multilocularis | aurora kinase A | 0.0123 | 0.3319 | 0.3341 |
Toxoplasma gondii | aurora kinase | 0.0123 | 0.3319 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0324 | 0.9806 | 0.9805 |
Schistosoma mansoni | tyrosine kinase | 0.0175 | 0.4991 | 0.4959 |
Loa Loa (eye worm) | AUR protein kinase | 0.0123 | 0.3319 | 0.3385 |
Schistosoma mansoni | tyrosine kinase | 0.0105 | 0.2725 | 0.2678 |
Onchocerca volvulus | 0.0022 | 0.0064 | 0.5 | |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0105 | 0.2725 | 0.2779 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0123 | 0.3319 | 0.3319 |
Echinococcus granulosus | aurora kinase A | 0.0123 | 0.3319 | 0.3341 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0123 | 0.3319 | 0.3341 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0123 | 0.3319 | 1 |
Loa Loa (eye worm) | ryanodine receptor | 0.0078 | 0.1864 | 0.1901 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.6077 | 0.6197 |
Entamoeba histolytica | protein kinase, putative | 0.0123 | 0.3319 | 1 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0267 | 0.7974 | 0.8119 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0123 | 0.3319 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0171 | 0.4883 | 0.485 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0324 | 0.9806 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0123 | 0.3319 | 1 |
Echinococcus multilocularis | 0.01 | 0.2572 | 0.2574 | |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0123 | 0.3319 | 0.3341 |
Schistosoma mansoni | protein kinase | 0.0123 | 0.3319 | 0.3276 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0123 | 0.3319 | 0.3276 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.1377 | 0.1405 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0105 | 0.2725 | 0.2732 |
Leishmania major | protein kinase, putative | 0.0123 | 0.3319 | 1 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0208 | 0.6077 | 0.6172 |
Loa Loa (eye worm) | AUR protein kinase | 0.0123 | 0.3319 | 0.3385 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0123 | 0.3319 | 0.3319 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0123 | 0.3319 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.5 uM | In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin | ChEMBL. | 12067561 |
IC50 (binding) | = 0.5 uM | In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin | ChEMBL. | 12067561 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.