Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.015 uM | Inhibition of solubilized partially purified rat liver HMG-CoA reductase | ChEMBL. | 3950902 |
IC50 (binding) | = 0.015 uM | Compound was tested in vitro for its ability to inhibit rat liver HMG-CoA reductase | ChEMBL. | 3701793 |
Relative potency (binding) | = 80 | Inhibitory potency against purified rat liver HMG-CoA reductase relative to compactin | ChEMBL. | 3950902 |
Relative potency (binding) | = 80 | compound was tested for its ability to inhibit solubilized, purified rat liver HMG-CoA reductase, relative to compactin(100) | ChEMBL. | 3701793 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.