TDR Targets

Basic information

Technical information

TDR Targets ID: 774920
Name: ethyl 2-amino-1'-(2-methoxy-2-oxoethyl)-7,7-d imethyl-2',5-dioxospiro[6,8-dihydrochromene-4 ,3'-indole]-3-carboxylate
MW: 454.472 | Formula: C24H26N2O7
H donors: 1 H acceptors: 4 LogP: 2.08 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)C1=C(N)OC2=C(C31C(=O)N(c1c3cccc1)CC(=O)OC)C(=O)CC(C2)(C)C
InChi: 1S/C24H26N2O7/c1-5-32-21(29)19-20(25)33-16-11-23(2,3)10-15(27)18(16)24(19)13-8-6-7-9-14(13)26(22(24)30)12-17(28)31-4/h6-9H,5,10-12,25H2,1-4H3
InChiKey: GLDFXNNLPBTTEO-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

ethyl 2-amino-1'-(2-methoxy-2-oxo-ethyl)-7,7-dimethyl-2',5-dioxo-spiro[6,8-dihydrochromene-4,3'-indoline]-3-carboxylate
2-amino-1'-(2-methoxy-2-oxoethyl)-7,7-dimethyl-2',5-dioxo-3-spiro[6,8-dihydrochromene-4,3'-indoline]carboxylic acid ethyl ester
2-amino-2',5-diketo-1'-(2-keto-2-methoxy-ethyl)-7,7-dimethyl-spiro[6,8-dihydrochromene-4,3'-indoline]-3-carboxylic acid ethyl ester
ethyl 2-amino-1'-(2-methoxy-2-oxo-ethyl)-7,7-dimethyl-2',5-dioxo-spiro[6,8-dihydrochromene-4,3'-indole]-3-carboxylate
UNM000000663901
EU-0013648

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.007	0.3004	0.3815
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0352	0.0147
Schistosoma mansoni	nAChR subunit	0.007	0.3004	0.3004
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.007	0.3004	0.3004
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1025	0.1302
Loa Loa (eye worm)	hypothetical protein	0.007	0.3004	0.3815
Loa Loa (eye worm)	hypothetical protein	0.007	0.3004	0.3815
Loa Loa (eye worm)	hypothetical protein	0.007	0.3004	0.3815
Echinococcus multilocularis	glycine receptor subunit beta	0.007	0.3004	0.3004
Loa Loa (eye worm)	hypothetical protein	0.007	0.3004	0.3815
Echinococcus multilocularis	nAChR subunit	0.0042	0.1025	0.1025
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.007	0.3004	0.3004
Echinococcus granulosus	expressed protein	0.0033	0.0352	0.0352
Leishmania major	pantothenate kinase subunit, putative	0.0085	0.4029	1
Schistosoma mansoni	nAChR subunit	0.007	0.3004	0.3004
Onchocerca volvulus	Putative nachr subunit	0.007	0.3004	0.3815
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0033	0.0352	0.0448
Brugia malayi	Cation transporter family protein	0.007	0.3004	0.3815
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0139	0.7874	0.7874
Schistosoma mansoni	pantothenate kinase	0.0085	0.4029	0.4029
Brugia malayi	Cation transporter family protein	0.007	0.3004	0.3815
Echinococcus multilocularis	pantothenate kinase 4	0.0085	0.4029	0.4029
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.007	0.3004	0.3004
Echinococcus granulosus	glycine receptor subunit beta	0.007	0.3004	0.3004
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.007	0.3004	0.3004
Entamoeba histolytica	pantothenate kinase 1, putative	0.0085	0.4029	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1025	0.1302
Loa Loa (eye worm)	hypothetical protein	0.007	0.3004	0.3815
Loa Loa (eye worm)	hypothetical protein	0.007	0.3004	0.3815
Trichomonas vaginalis	rotamase, putative	0.0033	0.0352	0.0147
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.007	0.3004	0.3004
Echinococcus granulosus	glycine receptor subunit alpha 1	0.007	0.3004	0.3004
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0042	0.1025	0.1302
Loa Loa (eye worm)	GABA receptor subunit	0.0042	0.1025	0.1302
Entamoeba histolytica	hypothetical protein	0.0042	0.1025	0.1951
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.007	0.3004	0.3815
Onchocerca volvulus		0.007	0.3004	0.3815
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.007	0.3004	0.3815
Loa Loa (eye worm)	hypothetical protein	0.007	0.3004	0.3815
Echinococcus multilocularis	expressed protein	0.0033	0.0352	0.0352
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.007	0.3004	0.3004
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.007	0.3004	0.3004
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0033	0.0352	0.0448
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.007	0.3004	0.3004
Schistosoma mansoni	nAChR subunit	0.007	0.3004	0.3004
Loa Loa (eye worm)	hypothetical protein	0.0111	0.5895	0.7487
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.007	0.3004	0.3815
Schistosoma mansoni	nAChR subunit	0.007	0.3004	0.3004
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.007	0.3004	0.3815
Onchocerca volvulus		0.0042	0.1025	0.1302
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.007	0.3004	0.3815
Giardia lamblia	Pantothenate kinase 4	0.0085	0.4029	0.5
Loa Loa (eye worm)	pantothenate kinase	0.0085	0.4029	0.5117
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.007	0.3004	0.3004
Trypanosoma cruzi	pantothenate kinase subunit, putative	0.0085	0.4029	1
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.007	0.3004	0.3815
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.007	0.3004	0.3815
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0042	0.1025	0.1302
Toxoplasma gondii	fumble protein	0.0085	0.4029	1
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.007	0.3004	0.3815
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.007	0.3004	0.3004
Onchocerca volvulus	Fumble homolog	0.0085	0.4029	0.5117
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.007	0.3004	0.3815
Schistosoma mansoni	rotamase	0.0033	0.0352	0.0352
Schistosoma mansoni	nAChR subunit	0.007	0.3004	0.3004
Loa Loa (eye worm)	hypothetical protein	0.007	0.3004	0.3815
Schistosoma mansoni	neurotransmitter gated ion channel	0.0042	0.1025	0.1025
Toxoplasma gondii	pantothenate kinase	0.0036	0.0559	0.0701
Echinococcus granulosus	nAChR subunit	0.007	0.3004	0.3004
Loa Loa (eye worm)	ACC-1 protein	0.007	0.3004	0.3815
Echinococcus granulosus	glycine receptor subunit beta	0.007	0.3004	0.3004
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1025	0.1302
Onchocerca volvulus		0.0139	0.7874	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.3004	0.3815
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.007	0.3004	0.3004
Brugia malayi	pantothenate kinase family protein	0.0085	0.4029	0.5117
Plasmodium falciparum	pantothenate kinase 1, putative	0.0085	0.4029	1
Loa Loa (eye worm)	hypothetical protein	0.0139	0.7874	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0042	0.1025	0.1302
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.007	0.3004	0.3815
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.007	0.3004	0.3815
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0042	0.1025	0.1025
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.007	0.3004	0.3815
Trichomonas vaginalis	pantothenate kinase, putative	0.0085	0.4029	1
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.007	0.3004	0.3004
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1025	0.1302
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.007	0.3004	0.3815
Echinococcus granulosus	pantothenate kinase 4	0.0085	0.4029	0.4029
Loa Loa (eye worm)	hypothetical protein	0.007	0.3004	0.3815
Plasmodium vivax	pantothenate kinase, putative	0.0085	0.4029	1
Brugia malayi	Cation transporter family protein	0.0139	0.7874	1
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.007	0.3004	0.3815
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1025	0.1302
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.007	0.3004	0.3004
Echinococcus granulosus	glycine receptor subunit alpha 1	0.007	0.3004	0.3004
Loa Loa (eye worm)	hypothetical protein	0.0139	0.7874	1
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.007	0.3004	0.3004
Onchocerca volvulus		0.0139	0.7874	1
Echinococcus multilocularis	geminin	0.0169	1	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.3004	0.3815
Schistosoma mansoni	hypothetical protein	0.0169	1	1
Trichomonas vaginalis	pantothenate kinase, putative	0.0085	0.4029	1
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.007	0.3004	0.3815
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.007	0.3004	0.3815
Trypanosoma brucei	pantothenate kinase subunit, putative	0.0085	0.4029	1
Schistosoma mansoni	nAChR subunit	0.007	0.3004	0.3004
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.007	0.3004	0.3004
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.007	0.3004	0.3815
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.007	0.3004	0.3004
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.007	0.3004	0.3004
Loa Loa (eye worm)	ACC-1 protein	0.007	0.3004	0.3815
Onchocerca volvulus		0.0139	0.7874	1
Onchocerca volvulus		0.007	0.3004	0.3815
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.007	0.3004	0.3815
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.007	0.3004	0.3815
Loa Loa (eye worm)	hypothetical protein	0.007	0.3004	0.3815
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.007	0.3004	0.3004
Echinococcus granulosus	glycine receptor subunit alpha 1	0.007	0.3004	0.3004
Trypanosoma cruzi	pantothenate kinase subunit, putative	0.0085	0.4029	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.007	0.3004	0.3004
Loa Loa (eye worm)	hypothetical protein	0.007	0.3004	0.3815
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.1491	0.32
Schistosoma mansoni	nAChR subunit	0.007	0.3004	0.3004
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0042	0.1025	0.1302
Echinococcus granulosus	nAChR subunit	0.0042	0.1025	0.1025
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.007	0.3004	0.3004
Brugia malayi	excitatory GABA receptor EXP-1A	0.007	0.3004	0.3815
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.007	0.3004	0.3815
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.007	0.3004	0.3004
Echinococcus multilocularis	glycine receptor subunit beta	0.007	0.3004	0.3004
Loa Loa (eye worm)	hypothetical protein	0.007	0.3004	0.3815
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0042	0.1025	0.1025
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1025	0.1302
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0139	0.7874	0.7874
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1025	0.1302
Onchocerca volvulus		0.0042	0.1025	0.1302
Schistosoma mansoni	pantothenate kinase	0.0085	0.4029	0.4029
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1025	0.1302
Trichomonas vaginalis	pantothenate kinase, putative	0.0085	0.4029	1
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.007	0.3004	0.3815
Loa Loa (eye worm)	hypothetical protein	0.007	0.3004	0.3815
Onchocerca volvulus		0.007	0.3004	0.3815
Schistosoma mansoni	hypothetical protein	0.0169	1	1
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.007	0.3004	0.3004
Loa Loa (eye worm)	hypothetical protein	0.007	0.3004	0.3815
Trichomonas vaginalis	pantothenate kinase, putative	0.0085	0.4029	1
Trichomonas vaginalis	pantothenate kinase, putative	0.0085	0.4029	1
Loa Loa (eye worm)	LGC-31 protein	0.007	0.3004	0.3815
Loa Loa (eye worm)	hypothetical protein	0.007	0.3004	0.3815
Echinococcus multilocularis	nAChR subunit	0.007	0.3004	0.3004

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 774920