Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | pantothenate kinase 1, putative | 0.0086 | 0.3979 | 0.5 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0071 | 0.2368 | 0.304 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 1 | 1 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0071 | 0.2368 | 0.304 |
Echinococcus granulosus | pantothenate kinase 4 | 0.0086 | 0.3979 | 1 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0071 | 0.2368 | 0.304 |
Echinococcus multilocularis | nAChR subunit | 0.0071 | 0.2368 | 0.304 |
Echinococcus granulosus | nAChR subunit | 0.0071 | 0.2368 | 0.304 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0071 | 0.2368 | 0.0844 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2368 | 0.0844 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0071 | 0.2368 | 0.0844 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0071 | 0.2368 | 0.0844 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0071 | 0.2368 | 0.304 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0071 | 0.2368 | 0.304 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0071 | 0.2368 | 0.0844 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0071 | 0.2368 | 0.0844 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0071 | 0.2368 | 0.0844 |
Leishmania major | pantothenate kinase subunit, putative | 0.0086 | 0.3979 | 1 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0071 | 0.2368 | 0.0844 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0071 | 0.2368 | 0.304 |
Giardia lamblia | Pantothenate kinase 4 | 0.0086 | 0.3979 | 0.5 |
Trichomonas vaginalis | pantothenate kinase, putative | 0.0086 | 0.3979 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0071 | 0.2368 | 0.0844 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0071 | 0.2368 | 0.0844 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0071 | 0.2368 | 0.0844 |
Schistosoma mansoni | pantothenate kinase | 0.0086 | 0.3979 | 0.2777 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0071 | 0.2368 | 0.0844 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0141 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2368 | 0.0844 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2368 | 0.0844 |
Schistosoma mansoni | nAChR subunit | 0.0071 | 0.2368 | 0.0844 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0071 | 0.2368 | 0.304 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2368 | 0.0844 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2368 | 0.0844 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2368 | 0.0844 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0071 | 0.2368 | 0.0844 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0071 | 0.2368 | 0.0844 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0071 | 0.2368 | 0.0844 |
Schistosoma mansoni | nAChR subunit | 0.0071 | 0.2368 | 0.0844 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2368 | 0.0844 |
Schistosoma mansoni | nAChR subunit | 0.0071 | 0.2368 | 0.0844 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 1 | 1 |
Onchocerca volvulus | Fumble homolog | 0.0086 | 0.3979 | 0.2111 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0071 | 0.2368 | 0.0844 |
Loa Loa (eye worm) | LGC-31 protein | 0.0071 | 0.2368 | 0.0844 |
Onchocerca volvulus | 0.0141 | 1 | 1 | |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0071 | 0.2368 | 0.0844 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0071 | 0.2368 | 0.304 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.6899 | 0.628 |
Onchocerca volvulus | 0.0141 | 1 | 1 | |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0071 | 0.2368 | 0.0844 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0071 | 0.2368 | 0.304 |
Trichomonas vaginalis | rotamase, putative | 0.0065 | 0.1664 | 0.4182 |
Plasmodium vivax | pantothenate kinase, putative | 0.0086 | 0.3979 | 0.5 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0071 | 0.2368 | 0.304 |
Loa Loa (eye worm) | pantothenate kinase | 0.0086 | 0.3979 | 0.2777 |
Echinococcus multilocularis | pantothenate kinase 4 | 0.0086 | 0.3979 | 1 |
Trichomonas vaginalis | pantothenate kinase, putative | 0.0086 | 0.3979 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0071 | 0.2368 | 0.304 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0071 | 0.2368 | 0.0844 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0071 | 0.2368 | 0.0844 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0071 | 0.2368 | 0.304 |
Schistosoma mansoni | nAChR subunit | 0.0071 | 0.2368 | 0.0844 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0071 | 0.2368 | 0.304 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0071 | 0.2368 | 0.304 |
Toxoplasma gondii | fumble protein | 0.0086 | 0.3979 | 1 |
Trichomonas vaginalis | pantothenate kinase, putative | 0.0086 | 0.3979 | 1 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0071 | 0.2368 | 0.0844 |
Schistosoma mansoni | nAChR subunit | 0.0071 | 0.2368 | 0.0844 |
Entamoeba histolytica | pantothenate kinase 1, putative | 0.0086 | 0.3979 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0071 | 0.2368 | 0.304 |
Brugia malayi | Cation transporter family protein | 0.0071 | 0.2368 | 0.0844 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2368 | 0.0844 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2368 | 0.0844 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0071 | 0.2368 | 0.304 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0071 | 0.2368 | 0.0844 |
Trichomonas vaginalis | rotamase, putative | 0.0063 | 0.1497 | 0.3762 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0071 | 0.2368 | 0.0844 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0071 | 0.2368 | 0.0844 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0071 | 0.2368 | 0.0844 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0071 | 0.2368 | 0.0844 |
Brugia malayi | Cation transporter family protein | 0.0071 | 0.2368 | 0.0844 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0071 | 0.2368 | 0.304 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2368 | 0.0844 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0065 | 0.1664 | 0.4182 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2368 | 0.0844 |
Trypanosoma brucei | pantothenate kinase subunit, putative | 0.0086 | 0.3979 | 1 |
Schistosoma mansoni | pantothenate kinase | 0.0086 | 0.3979 | 0.2777 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0071 | 0.2368 | 0.304 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0071 | 0.2368 | 0.304 |
Trichomonas vaginalis | pantothenate kinase, putative | 0.0086 | 0.3979 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0071 | 0.2368 | 0.0844 |
Onchocerca volvulus | 0.0141 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2368 | 0.0844 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0071 | 0.2368 | 0.304 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0071 | 0.2368 | 0.304 |
Trichomonas vaginalis | pantothenate kinase, putative | 0.0086 | 0.3979 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0071 | 0.2368 | 0.0844 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2368 | 0.0844 |
Trypanosoma cruzi | pantothenate kinase subunit, putative | 0.0086 | 0.3979 | 1 |
Trypanosoma cruzi | pantothenate kinase subunit, putative | 0.0086 | 0.3979 | 1 |
Loa Loa (eye worm) | ACC-1 protein | 0.0071 | 0.2368 | 0.0844 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0071 | 0.2368 | 0.304 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0071 | 0.2368 | 0.304 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0071 | 0.2368 | 0.0844 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0141 | 1 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0071 | 0.2368 | 0.0844 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2368 | 0.0844 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2368 | 0.0844 |
Brugia malayi | pantothenate kinase family protein | 0.0086 | 0.3979 | 0.2777 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0071 | 0.2368 | 0.304 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0071 | 0.2368 | 0.304 |
Loa Loa (eye worm) | ACC-1 protein | 0.0071 | 0.2368 | 0.0844 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2368 | 0.0844 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2368 | 0.0844 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.