Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0016 | 0.043 | 0.0444 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.001 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0104 | 0.6611 | 0.6834 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0048 | 0.2678 | 0.2768 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.6611 | 0.6611 |
Entamoeba histolytica | hypothetical protein | 0.001 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.2678 | 0.2768 |
Mycobacterium ulcerans | NAD-dependent DNA ligase LigA | 0.001 | 0 | 0.5 |
Brugia malayi | Isocitrate dehydrogenase | 0.0016 | 0.043 | 0.043 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2678 | 0.2678 |
Chlamydia trachomatis | DNA ligase | 0.001 | 0 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.043 | 1 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0016 | 0.043 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0048 | 0.2678 | 0.2768 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.043 | 0.0444 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0048 | 0.2678 | 0.2678 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0048 | 0.2678 | 0.2768 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0152 | 1 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0016 | 0.043 | 0.043 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0125 | 0.8134 | 0.8134 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.2678 | 0.2768 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0016 | 0.043 | 1 |
Loa Loa (eye worm) | potassium voltage-gated channel subfamily Q member 5 | 0.0066 | 0.3961 | 0.3961 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0.043 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0 | 0.5 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.001 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0 | 0.5 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0016 | 0.043 | 0.0444 |
Giardia lamblia | Replication factor C, subunit 1 | 0.001 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0104 | 0.6611 | 0.6611 |
Brugia malayi | Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog | 0.0147 | 0.9673 | 0.9673 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.043 | 1 |
Treponema pallidum | DNA ligase (lig) | 0.001 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | NAD-dependent DNA ligase, Lig | 0.001 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.2678 | 0.2768 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0016 | 0.043 | 1 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.043 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.3961 | 0.3961 |
Echinococcus multilocularis | potassium voltage gated channel subfamily KQT | 0.0147 | 0.9673 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0048 | 0.2678 | 0.2678 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.3961 | 0.3961 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0048 | 0.2678 | 0.2768 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0125 | 0.8134 | 0.8134 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0016 | 0.043 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0048 | 0.2678 | 0.2768 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0.043 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0016 | 0.043 | 0.0444 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.2678 | 0.2768 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0152 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.043 | 0.0444 |
Entamoeba histolytica | Activator 1 140 kDa subunit, putative | 0.001 | 0 | 0.5 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0048 | 0.2678 | 0.2768 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.043 | 0.0444 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.043 | 0.0444 |
Brugia malayi | isocitrate dehydrogenase | 0.0016 | 0.043 | 0.043 |
Schistosoma mansoni | voltage-gated potassium channel KCNQ | 0.0147 | 0.9673 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily KQT | 0.0066 | 0.3961 | 0.4095 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0048 | 0.2678 | 0.2678 |
Brugia malayi | MH2 domain containing protein | 0.0125 | 0.8134 | 0.8134 |
Echinococcus granulosus | potassium voltage gated channel subfamily KQT | 0.0066 | 0.3961 | 0.4095 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0.043 | 0.5 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 1 | 1 |
Loa Loa (eye worm) | voltage-gated potassium channel | 0.0145 | 0.9498 | 0.9498 |
Mycobacterium leprae | PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) | 0.001 | 0 | 0.5 |
Echinococcus granulosus | potassium channel KvQLT family member kqt 1 | 0.0147 | 0.9673 | 1 |
Trichomonas vaginalis | replication factor C large subunit, putative | 0.001 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.