Detailed information for compound 77588

Basic information

Technical information
  • TDR Targets ID: 77588
  • Name: 6-[[(4-methoxynaphthalen-1-yl)amino]methyl]-5 -methylpyrido[2,3-d]pyrimidine-2,4-diamine
  • MW: 360.412 | Formula: C20H20N6O
  • H donors: 3 H acceptors: 3 LogP: 3.17 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(c2c1cccc2)NCc1cnc2c(c1C)c(N)nc(n2)N
  • InChi: 1S/C20H20N6O/c1-11-12(10-24-19-17(11)18(21)25-20(22)26-19)9-23-15-7-8-16(27-2)14-6-4-3-5-13(14)15/h3-8,10,23H,9H2,1-2H3,(H4,21,22,24,25,26)
  • InChiKey: WRDIIGHJSQOTJF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-[[(4-methoxy-1-naphthyl)amino]methyl]-5-methyl-pyrido[2,3-d]pyrimidine-2,4-diamine
  • 6-[[(4-methoxy-1-naphthyl)amino]methyl]-5-methylpyrido[2,3-d]pyrimidine-2,4-diamine
  • 6-[[(4-methoxynaphthalen-1-yl)amino]methyl]-5-methyl-pyrido[2,3-d]pyrimidine-2,4-diamine
  • (2,4-diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-yl)methyl-(4-methoxy-1-naphthyl)amine
  • 6-[[(4-methoxynaphthalen-1-yl)amino]methyl]-5-methylpyrido[3,2-e]pyrimidine-2,4-diamine
  • 6-[[(4-methoxy-1-naphthyl)amino]methyl]-5-methyl-pyrido[3,2-e]pyrimidine-2,4-diamine
  • 6-[[(4-methoxy-1-naphthyl)amino]methyl]-5-methylpyrido[3,2-e]pyrimidine-2,4-diamine
  • (2,4-diamino-5-methyl-pyrido[5,6-e]pyrimidin-6-yl)methyl-(4-methoxy-1-naphthyl)amine
  • 6-[[(4-methoxynaphthalen-1-yl)amino]methyl]-5-methyl-pyrido[3,2-e]pyrimidine-2,4-diamine
  • 6-[(4-Methoxy-naphthalen-1-ylamino)-methyl]-5-methyl-pyrido[2,3-d]pyrimidine-2,4-diamine
  • AIDS-032339
  • AIDS032339

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Dihydrofolate reductase Starlite/ChEMBL References
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase Starlite/ChEMBL References
Pneumocystis carinii Dihydrofolate reductase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium yoelii thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans hypothetical protein Get druggable targets OG5_128410 All targets in OG5_128410
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) Get druggable targets OG5_127385 All targets in OG5_127385
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) Get druggable targets OG5_128410 All targets in OG5_128410
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium knowlesi bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Brugia malayi thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania mexicana dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus granulosus thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus granulosus dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Chlamydia trachomatis dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Cryptosporidium parvum dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Onchocerca volvulus Get druggable targets OG5_127385 All targets in OG5_127385
Babesia bovis dihydrofolate reductase/thymidilate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma japonicum ko:K00287 dihydrofolate reductase [EC1.5.1.3], putative Get druggable targets OG5_128410 All targets in OG5_128410
Brugia malayi dihydrofolate reductase family protein Get druggable targets OG5_128410 All targets in OG5_128410
Echinococcus multilocularis thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C) Get druggable targets OG5_127385 All targets in OG5_127385
Brugia malayi Dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Candida albicans Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C) Get druggable targets OG5_127385 All targets in OG5_127385
Loa Loa (eye worm) thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma mansoni dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Candida albicans dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Theileria parva dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium ulcerans dihydrofolate reductase DfrA Get druggable targets OG5_128410 All targets in OG5_128410
Mycobacterium ulcerans thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania major dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma japonicum ko:K00560 thymidylate synthase [EC2.1.1.45], putative Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Leishmania braziliensis dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania donovani dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania infantum dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Neospora caninum Bifunctional dihydrofolate reductase-thymidylate synthase, related Get druggable targets OG5_127385 All targets in OG5_127385
Trypanosoma brucei gambiense dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) Get druggable targets OG5_128410 All targets in OG5_128410
Echinococcus multilocularis dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Loa Loa (eye worm) dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium berghei bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Cryptosporidium hominis chain A, crystal structure of Dhfr Get druggable targets OG5_127385 All targets in OG5_127385
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Theileria parva dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   187 aa 193 aa 32.1 %
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 202 aa 29.2 %
Cryptosporidium hominis chain A, crystal structure of Dhfr Dihydrofolate reductase   187 aa 182 aa 34.1 %
Leishmania braziliensis dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 172 aa 34.3 %
Cryptosporidium parvum dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 182 aa 33.5 %
Neospora caninum Bifunctional dihydrofolate reductase-thymidylate synthase, related Dihydrofolate reductase   187 aa 187 aa 35.8 %
Leishmania infantum dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 172 aa 36.0 %
Leishmania donovani dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 172 aa 36.0 %
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 210 aa 30.0 %
Leishmania mexicana dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 172 aa 33.7 %
Trypanosoma brucei gambiense dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 210 aa 30.0 %
Plasmodium yoelii thymidylate synthase, putative Dihydrofolate reductase   187 aa 212 aa 27.8 %
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   206 aa 193 aa 29.5 %
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 186 aa 37.1 %
Babesia bovis dihydrofolate reductase/thymidilate synthase Dihydrofolate reductase   187 aa 191 aa 31.9 %
Plasmodium berghei bifunctional dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   187 aa 211 aa 28.4 %
Leishmania major dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 172 aa 36.0 %
Plasmodium knowlesi bifunctional dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   187 aa 209 aa 29.2 %
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   187 aa 209 aa 29.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) thymidylate synthase 0.013 0.1049 0.0392
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0468 0.3845 1
Echinococcus multilocularis thymidylate synthase 0.013 0.1049 0.1049
Schistosoma mansoni dihydrofolate reductase 0.0468 0.3845 0.3124
Brugia malayi thymidylate synthase 0.013 0.1049 0.0591
Brugia malayi dihydrofolate reductase family protein 0.0468 0.3845 0.353
Echinococcus multilocularis dihydrofolate reductase 0.0468 0.3845 0.3845
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0341 0.2798 0.5
Brugia malayi olfactory channel protein osm-9 0.0086 0.0683 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0486 0.5
Echinococcus granulosus calcium release activated calcium channel 0.1213 1 1
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0341 0.2798 1
Schistosoma mansoni Protein orai-1 0.1213 1 1
Brugia malayi Dihydrofolate reductase 0.0468 0.3845 0.353
Echinococcus granulosus dihydrofolate reductase 0.0468 0.3845 0.3845
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0341 0.2798 0.5
Chlamydia trachomatis dihydrofolate reductase 0.0468 0.3845 0.5
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0341 0.2798 0.5
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0341 0.2798 0.5
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0468 0.3845 1
Schistosoma mansoni Protein orai-1 0.1213 1 1
Echinococcus granulosus thymidylate synthase 0.013 0.1049 0.1049
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.013 0.1049 0.1674
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0468 0.3845 1
Onchocerca volvulus 0.013 0.1049 0.5
Loa Loa (eye worm) hypothetical protein 0.1213 1 1
Loa Loa (eye worm) dihydrofolate reductase 0.0468 0.3845 0.3393
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0341 0.2798 0.5
Echinococcus multilocularis calcium release activated calcium channel 0.1213 1 1

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) = 0.0000000117 M Cytotoxic activity against HCT-116 colon cancer cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000117 M Cytotoxic activity against HCT-116 colon cancer cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000161 M Cytotoxic activity against K-562 Leukemia cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000161 M Cytotoxic activity against K-562 Leukemia cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000188 M Cytotoxic activity against MDA-MB-231/ATCC Breast cancer cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000188 M Cytotoxic activity against MDA-MB-231/ATCC Breast cancer cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000384 M Cytotoxic activity against A549/ATCC non-small cell-lung cancer cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000384 M Cytotoxic activity against A549/ATCC non-small cell-lung cancer cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000425 M Cytotoxic activity against MDA-N Breast cancer cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000425 M Cytotoxic activity against MDA-N Breast cancer cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000432 M Cytotoxic activity against UACC-62 Melanoma cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000432 M Cytotoxic activity against 786-0 Renal cancer cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000432 M Cytotoxic activity against UACC-62 Melanoma cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000432 M Cytotoxic activity against 786-0 Renal cancer cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000456 M Cytotoxic activity against HCT-15 colon cancer cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000456 M Cytotoxic activity against HCT-15 colon cancer cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000491 M Cytotoxic activity against NCI-H460 non-small cell-lung cancer cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000491 M Cytotoxic activity against NCI-H460 non-small cell-lung cancer cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000521 M Cytotoxic activity against DU-145 Prostate cancer cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000521 M Cytotoxic activity against DU-145 Prostate cancer cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000578 M Cytotoxic activity against SK-MEL-5 Melanoma cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000578 M Cytotoxic activity against SK-MEL-5 Melanoma cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000604 M Cytotoxic activity against SF-268 CNS canser cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000604 M Cytotoxic activity against SF-268 CNS canser cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000621 M Cytotoxic activity against MDA-MB-435 Breast cancer cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000621 M Cytotoxic activity against MDA-MB-435 Breast cancer cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000694 M Cytotoxic activity against LOXIMVI Melanoma cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000694 M Cytotoxic activity against LOXIMVI Melanoma cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000723 M Cytotoxic activity against HT-29 colon cancer cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000723 M Cytotoxic activity against HT-29 colon cancer cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000729 M Cytotoxic activity against U251 CNS cancer cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000729 M Cytotoxic activity against U251 CNS cancer cell line ChEMBL. 7752201
GI50 (functional) = 0.000000076 M Cytotoxic activity against SR Leukemia cell line ChEMBL. 7752201
GI50 (functional) = 0.000000076 M Cytotoxic activity against SR Leukemia cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000766 M Cytotoxic activity against CCRF-CEM Leukemia cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000766 M Cytotoxic activity against CCRF-CEM Leukemia cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000796 M Cytotoxic activity against SW-620 colon cancer cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000796 M Cytotoxic activity against SW-620 colon cancer cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000798 M Cytotoxic activity against PC-3 Prostate cancer cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000798 M Cytotoxic activity against PC-3 Prostate cancer cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000832 M Cytotoxic activity against SF-295 CNS cancer cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000832 M Cytotoxic activity against SF-295 CNS cancer cell line ChEMBL. 7752201
GI50 (functional) = 0.000000085 M Cytotoxic activity against NCI-H322M non-small cell-lung cancer cell line ChEMBL. 7752201
GI50 (functional) = 0.000000085 M Cytotoxic activity against NCI-H322M non-small cell-lung cancer cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000868 M Cytotoxic activity against UACC-257 Melanoma cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000868 M Cytotoxic activity against IGROV1 Ovarian cancer cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000868 M Cytotoxic activity against ACHN Renal cancer cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000868 M Cytotoxic activity against UACC-257 Melanoma cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000868 M Cytotoxic activity against ACHN Renal cancer cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000911 M Cytotoxic activity against MOLT-4 Leukemia cell line ChEMBL. 7752201
GI50 (functional) = 0.0000000911 M Cytotoxic activity against MOLT-4 Leukemia cell line ChEMBL. 7752201
IC50 (binding) = 7.2676 Inhibition of rat liver dihydrofolate reductase ChEMBL. 15743188
IC50 (binding) = 7.3872 Inhibition of Pneumocystis carinii dihydrofolate reductase ChEMBL. 15743188
IC50 (binding) = 7.6383 Inhibition of Toxoplasma gondii dihydrofolate reductase ChEMBL. 15743188
IC50 (binding) = 23 nM Inhibitory activity against Dihydrofolate reductase from Toxoplasma gondii ChEMBL. 7752201
IC50 (binding) = 23 nM Inhibitory activity against Dihydrofolate reductase from Toxoplasma gondii ChEMBL. 7752201
IC50 (binding) = 41 nM Inhibitory activity against Dihydrofolate reductase from Pneumocystis carinii ChEMBL. 7752201
IC50 (binding) = 41 nM Inhibitory activity against Dihydrofolate reductase from Pneumocystis carinii ChEMBL. 7752201
IC50 (binding) = 54 nM Inhibitory activity against Dihydrofolate reductase from rat liver ChEMBL. 7752201
IC50 (binding) = 54 nM Inhibitory activity against Dihydrofolate reductase from rat liver ChEMBL. 7752201
IC50 (binding) = 0.023 uM Inhibition of Toxoplasma gondii dihydrofolate reductase ChEMBL. 15743188
IC50 (binding) = 0.023 uM Inhibition of Toxoplasma gondii dihydrofolate reductase ChEMBL. 15743188
IC50 (functional) = 0.04 uM Inhibitory activity against cultured Toxoplasma gondii ChEMBL. 7752201
IC50 (functional) = 0.04 uM Inhibitory activity against cultured Toxoplasma gondii ChEMBL. 7752201
IC50 (binding) = 0.041 uM Inhibition of Pneumocystis carinii dihydrofolate reductase ChEMBL. 15743188
IC50 (binding) = 0.041 uM Inhibition of Pneumocystis carinii dihydrofolate reductase ChEMBL. 15743188
IC50 (binding) = 0.054 uM Inhibition of rat liver dihydrofolate reductase ChEMBL. 15743188
IC50 (binding) = 0.054 uM Inhibition of rat liver dihydrofolate reductase ChEMBL. 15743188
Log IC50 (binding) = 7.2676 Inhibition of rat liver dihydrofolate reductase ChEMBL. 15743188
Log IC50 (binding) = 7.3872 Inhibition of Pneumocystis carinii dihydrofolate reductase ChEMBL. 15743188
Log IC50 (binding) = 7.6383 Inhibition of Toxoplasma gondii dihydrofolate reductase ChEMBL. 15743188
Ratio (binding) = 1.3 Ratio of the inhibitory concentrations against rat liver DHFR and Pneumocystis carinii DHFR ChEMBL. 7752201
Ratio (binding) = 2 Ratio of the inhibitory concentrations of the compound against Toxoplasma gondii DHFR in culture and Toxoplasma gondii DHFR. ChEMBL. 7752201
Ratio (binding) = 2.3 Ratio of the inhibitory concentrations against rat liver DHFR and Toxoplasma gondii DHFR. ChEMBL. 7752201

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Toxoplasma gondii ChEMBL23 7752201

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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