Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Animal haem peroxidase family protein | 0.0209 | 0.7801 | 0.7801 |
Echinococcus multilocularis | peroxidasin | 0.0209 | 0.7801 | 0.7801 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.7801 | 0.7804 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0418 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0078 | 0.2467 | 0.5 |
Brugia malayi | Peroxidasin | 0.0209 | 0.7801 | 0.7801 |
Brugia malayi | Blistered cuticle protein 3 | 0.0209 | 0.7801 | 0.7801 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0021 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.7801 | 0.7804 |
Brugia malayi | Pax transcription factor protein 2 | 0.0263 | 0.9997 | 0.9997 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 0.683 | 0.8543 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.7801 | 0.7804 |
Onchocerca volvulus | Peroxidasin homolog | 0.0209 | 0.7801 | 0.0432 |
Brugia malayi | MH2 domain containing protein | 0.0131 | 0.4605 | 0.4605 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0.0418 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0418 | 1 |
Schistosoma mansoni | peroxidasin | 0.0209 | 0.7801 | 0.9757 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0078 | 0.2467 | 0.3086 |
Onchocerca volvulus | Peroxidase homolog | 0.0209 | 0.7801 | 0.0432 |
Entamoeba histolytica | hypothetical protein | 0.0078 | 0.2467 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0209 | 0.7801 | 0.7801 |
Echinococcus multilocularis | jun protein | 0.0263 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0209 | 0.7801 | 0.7804 |
Schistosoma mansoni | hypothetical protein | 0.0214 | 0.7995 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.7801 | 0.7804 |
Loa Loa (eye worm) | hypothetical protein | 0.0256 | 0.9707 | 0.971 |
Onchocerca volvulus | Dual oxidase homolog | 0.0209 | 0.7801 | 0.0432 |
Schistosoma mansoni | peroxidasin | 0.0209 | 0.7801 | 0.9757 |
Entamoeba histolytica | hypothetical protein | 0.0078 | 0.2467 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0418 | 0.0418 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0078 | 0.2467 | 0.2467 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.7801 | 0.7804 |
Brugia malayi | Animal haem peroxidase family protein | 0.0209 | 0.7801 | 0.7801 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.7801 | 0.7804 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.7801 | 0.7804 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0263 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0209 | 0.7801 | 0.7804 |
Onchocerca volvulus | Peroxidasin homolog | 0.0209 | 0.7801 | 0.0432 |
Onchocerca volvulus | 0.0209 | 0.7801 | 0.0432 | |
Echinococcus multilocularis | geminin | 0.0185 | 0.683 | 0.683 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0078 | 0.2467 | 0.2467 |
Entamoeba histolytica | hypothetical protein | 0.0078 | 0.2467 | 0.5 |
Onchocerca volvulus | 0.0209 | 0.7801 | 0.0432 | |
Brugia malayi | hypothetical protein | 0.0209 | 0.7801 | 0.7801 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0209 | 0.7801 | 0.7804 |
Brugia malayi | Animal haem peroxidase family protein | 0.0209 | 0.7801 | 0.7801 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.7801 | 0.7804 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.7801 | 0.7804 |
Brugia malayi | hypothetical protein | 0.0078 | 0.2467 | 0.2467 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.7801 | 0.7804 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0131 | 0.4605 | 0.4606 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.0418 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0418 | 1 |
Onchocerca volvulus | 0.0263 | 0.9997 | 1 | |
Schistosoma mansoni | jun-related protein | 0.0214 | 0.7995 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0418 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.0418 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0209 | 0.7801 | 0.0432 |
Echinococcus granulosus | geminin | 0.0185 | 0.683 | 0.683 |
Onchocerca volvulus | 0.0209 | 0.7801 | 0.0432 | |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.0418 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0263 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0209 | 0.7801 | 0.7804 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.7801 | 0.7804 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0209 | 0.7801 | 0.0432 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0263 | 0.9997 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0131 | 0.4605 | 0.4606 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.7801 | 0.7804 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0418 | 0.0418 |
Echinococcus granulosus | jun protein | 0.0263 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0209 | 0.7801 | 0.7801 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 0.683 | 0.8543 |
Brugia malayi | hypothetical protein | 0.0207 | 0.7702 | 0.7702 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.2467 | 0.3086 |
Echinococcus granulosus | peroxidasin | 0.0209 | 0.7801 | 0.7801 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0209 | 0.7801 | 0.7804 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.7801 | 0.7804 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.7801 | 0.7804 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0017 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
RBA (binding) | = 5 | Relative binding affinity against rat uterine estrogen receptor | ChEMBL. | 11356114 |
RHA (binding) | = 340 | Relative hydrolytic activity against esterase in rat hepatic microsomes | ChEMBL. | 11356114 |
RSA (functional) | = 0.5 | Relative stimulation of alkaline phosphatase (AlkP) activity in Ishikawa cells | ChEMBL. | 11356114 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.