Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Malate synthase G GlcB | 0.2253 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.0043 | 0.2093 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0165 | 0.0445 | 0.4511 |
Schistosoma mansoni | inhibitor of apoptosis protein | 0.0284 | 0.0986 | 1 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0165 | 0.0445 | 0.0242 |
Toxoplasma gondii | dihydrodipicolinate synthase | 0.0113 | 0.0208 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0445 | 0.4511 |
Echinococcus granulosus | inhibitor of apoptosis protein | 0.0284 | 0.0986 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0284 | 0.0986 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0165 | 0.0445 | 0.4511 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.0445 | 0.5 |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.0284 | 0.0986 | 1 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0284 | 0.0986 | 1 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0284 | 0.0986 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.0445 | 0.5 |
Trichomonas vaginalis | dihydrodipicolinate synthase, putative | 0.0113 | 0.0208 | 1 |
Mycobacterium ulcerans | malate synthase G | 0.2253 | 1 | 1 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.0284 | 0.0986 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0284 | 0.0986 | 1 |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.0284 | 0.0986 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.0043 | 0.2093 |
Onchocerca volvulus | Deterin homolog | 0.0284 | 0.0986 | 0.5 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 0.0445 | 0.4511 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.0043 | 0.2093 |
Loa Loa (eye worm) | hypothetical protein | 0.0284 | 0.0986 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 0.0445 | 0.4511 |
Chlamydia trachomatis | 4-hydroxy-tetrahydrodipicolinate synthase | 0.0113 | 0.0208 | 0.5 |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.0284 | 0.0986 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrodipicolinate synthase | 0.0113 | 0.0208 | 0.5 |
Onchocerca volvulus | 0.0284 | 0.0986 | 0.5 | |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.0445 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.0445 | 0.5 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0078 | 0.0043 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.63 uM | Inhibition of solubilized partially purified rat liver HMG-CoA reductase | ChEMBL. | 3950902 |
Relative potency (binding) | = 2.4 | Inhibitory potency against purified rat liver HMG-CoA reductase relative to compactin | ChEMBL. | 3950902 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.