Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D | Starlite/ChEMBL | No references |
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.0366 | 0.2021 | 0.3346 |
Loa Loa (eye worm) | hypothetical protein | 0.0363 | 0.1991 | 0.1991 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0366 | 0.2021 | 0.0037 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0366 | 0.2021 | 0.0037 |
Echinococcus granulosus | serine:threonine protein kinase MARK2 | 0.0366 | 0.2021 | 0.3346 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.0366 | 0.2021 | 0.3346 |
Echinococcus multilocularis | calcium activated potassium channel | 0.0366 | 0.2021 | 0.3346 |
Echinococcus granulosus | maternal embryonic leucine zipper kinase | 0.0734 | 0.6041 | 1 |
Echinococcus granulosus | serine:threonine protein kinase MARK2 | 0.0366 | 0.2021 | 0.3346 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0023 | 0.0023 |
Schistosoma mansoni | serine/threonine kinase | 0.1097 | 1 | 1 |
Onchocerca volvulus | 0.0182 | 0.0023 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0182 | 0.0023 | 0.0023 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1097 | 1 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/MELK protein kinase | 0.1097 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0366 | 0.2021 | 0.0037 |
Brugia malayi | Kinase associated domain 1 family protein | 0.0363 | 0.1991 | 0.1991 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0366 | 0.2021 | 0.0037 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0366 | 0.2021 | 0.0037 |
Echinococcus granulosus | calcium activated potassium channel | 0.0366 | 0.2021 | 0.3346 |
Echinococcus multilocularis | hypothetical protein | 0.0363 | 0.1991 | 0.3296 |
Echinococcus multilocularis | maternal embryonic leucine zipper kinase | 0.0734 | 0.6041 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | 0.1585 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.8275 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 3.6964 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 5.0119 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.9341 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.